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The Role of Interleukin-17 in Systemic Lupus Erythematosus

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TH17 Cells in Health and Disease

Abstract

Altered cytokine production has long been recognized to be involved in the immune pathogenesis of systemic lupus erythematosus (SLE). Interleukin 17 (IL-17) has recently been recognized as a contribution to the advancement of the auto-immune response and the expression of tissue injury. Increased production of IL-17 has been documented in humans with SLE and therefore validated its contribution to increased auto-antibody production and kidney inflammation. However, suppression of IL-17 production in lupus-prone mice results in disease improvement.

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Authors and Affiliations

  1. Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, CLS-937, Boston, MA, 02115, USA

    George C. Tsokos

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  1. José C. Crispín
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  2. Vasileios C. Kyttaris
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  3. George C. Tsokos
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Correspondence to George C. Tsokos .

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  1. King's College London, Department of Nephrology and Transplanta, Guy's Hospital, London, WC2R 2LS, United Kingdom

    Shuiping Jiang

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Crispín, J.C., Kyttaris, V.C., Tsokos, G.C. (2011). The Role of Interleukin-17 in Systemic Lupus Erythematosus. In: Jiang, S. (eds) TH17 Cells in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9371-7_20

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