Skip to main content
SpringerLink
Log in

Chemotherapy for Advanced Urothelial Tract Tumors

  • Chapter
Chemotherapy and Urological Malignancy

Part of the book series: Clinical Practice in Urology ((PRACTICE UROLOG))

Abstract

There are approximately 30000 new cases of bladder cancer and 10000 deaths annually in the United States. Although bladder tumors occur in patients under the age of 50 years, the majority of cases are aged between 65 and 70. In the Western Hemisphere and Europe, bladder tumors are of the transitional cell (epidermoid) variety in over 95 % of cases and only 3 % are adenocarcinoma—mostly in the dome of the bladder and of urachal origin. In contrast, schistosomiasis-induced or bilharzial bladder cancer in Egypt and in India is of the squamous cell variety in over 75 % of cases (Gad-el-Mawla et al. 1979). In the Western Hemisphere, a strong link to various chemical carcinogens as inciting or promoting agents has been firmly established (Cohen 1979) and it is therefore surprising that the incidence of bladder cancer has not increased significantly (thus far) in the United States during the past 10–20 years.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Al-Sarraf M, Amer MH, Vaitkevicius VK (1977) Chemotherapy and survival in patients with urinary bladder cancer. Proc Am Assoc Cancer Res 18: 116

    Google Scholar 

  • Burnard KG, Boyd PJR, Mayo ME (1976) Single-dose intravesical thiotepa as an adjuvant to cystodiathermy in the treatment of transitional cell bladder carcinoma. Br J Urol 48: 55–59

    Article  Google Scholar 

  • Carter SK (1978) Chemotherapy and senitorurinary oncology. Cancer Treat Rev 5: 85–93

    Article  PubMed  CAS  Google Scholar 

  • Cohen SM (1979) Urinary bladder carcinogenesis: Initiation-promotion. Semin Oncol6:157–160

    PubMed  CAS  Google Scholar 

  • Cross RJ, Glashan RW, Humphrey CS, Robinson MRG, Smith PH, Williams RE (1976) Treatment of advanced bladder cancer with adriamycin and 5-fluorouracil. Br J Urol 48: 609–615

    Article  PubMed  CAS  Google Scholar 

  • Cummings KB, Shipley WM, Einstein AB, Cutler SJ (1979) Current concepts in the management of patients with deeply invasive bladder carcinoma. Semin Oncol 6: 220–228

    PubMed  CAS  Google Scholar 

  • Duchek M, Edsymr F, Naeslund I (1980) 5-Fluorouracil in the treatment of recurrent cancer of the urinary bladder. In: Pavone-Macaluso M, Smith PH, Edsmyr F (eds) Bladder tumors and other topics in urological oncology. Plenum Press, New York, pp 381–385

    Google Scholar 

  • Early K, Elias EG, Mittelman A, Albert D, Murphy GP (1973) Mitomycin C in the treatment of metastatic transitional cell carcinoma of the bladder. Cancer 31: 1150–1153

    Article  PubMed  CAS  Google Scholar 

  • EORTC (1972) Clinical screening of epipodophyllotoxin VM-26 in malignant lymphomas and solid tumors. Br Med J ii: 744–748

    Google Scholar 

  • EORTC (1977) The treatment of advanced carcinoma of the bladder with a combination of adriamycin and 5-fluorouracil. Eur Urol 3: 276–278

    Google Scholar 

  • Farrow GM (1979) Pathologist’s role in bladder cancer. Semin Oncol 6: 198–206

    PubMed  CAS  Google Scholar 

  • Gad-el-Mawla N, Chevlen E, Hamza R, Ziegler JL (1979) Phase II trial of cis-dichlorodiammineplatinum (II) in cancer of the Bilharzial bladder. Cancer Treat Rep 63: 1577–1578

    PubMed  CAS  Google Scholar 

  • Hall RR, Bloom HJG, Freeman JE, Nawrocki A, Wallace DM, (1974) Methotrexate treatment for advanced bladder cancer. Br J Urol 46: 431–438

    Article  PubMed  CAS  Google Scholar 

  • Herr H (1980) Diamminedichloride platinum II in the treatment of advanced bladder cancer. J Urol 123: 953–955

    Google Scholar 

  • Mechl Z, Rovny F, Sopkova B (1977) VM-26 (4-demethyleppodophyllotoxin-beta-d-thenylidine glucoside) in the treatment of urinary bladder tumors. Neoplasma 24: 411–414

    PubMed  CAS  Google Scholar 

  • Merrin CE (1979) Treatment of genitourinary tumors with cis-dichlorodiammineplatinum (II): Experience in 250 patients. Cancer Treat Rep 63: 1579–1584

    PubMed  CAS  Google Scholar 

  • Merrin C, Cartagena R, Wajsman Z, Baumgartner G, Murphy GP (1975) Chemotherapy of bladder carcinoma with cyclophosphamide and adriamycin. J. Urol 114: 884–887

    PubMed  CAS  Google Scholar 

  • Murphy WM, Soloway MS (1980) The effect of Thio-Tepa on developed and established mammalian bladder tumors. Cancer 45: 870–875

    Article  PubMed  CAS  Google Scholar 

  • Natale RB, Yagoda A, Watson RC, Stover DE (1980) Phase II trial of neocarzinostatin in patients with bladder and prostatic cancer: Toxicity of a 5-day IV bolus schedule. Cancer 45: 2836–2842

    Article  PubMed  CAS  Google Scholar 

  • Natale R, Yagoda A, Watson RC, Whitmore WF, Blumenreich M, Braun D Jr (1981) Methotrexate: An active agent in bladder cancer. Cancer 47: 1246–1250

    Article  PubMed  CAS  Google Scholar 

  • Nissen NI, Pajak TF, Leone LA, Bloomfield CD, Kennedy BJ, Ellison RR, Silver RT, Weiss RB, Cuttner J, Falkson G, Kung F, Bersevin PR, Holland JF (1980) Clinical trial of VP16-213 (NSC 14150) IV twice weekly in advanced neoplastic disease. Cancer 45: 232–235

    Article  PubMed  CAS  Google Scholar 

  • O’Bryan RM, Baker LH, Gottlieb JE, Rivkin SE, Bascerzak SP, Grument GN, Salmon SE, Moon TE, Hoogstraten B (1977) Dose response evaluation of adriamycin in human neoplasia. Cancer 39:1940–1948

    Article  PubMed  Google Scholar 

  • Oliver RTD (1980) The place of chemotherapy in the treatment of patients with invasive carcinoma of the bladder. In: Pavone-Macaluso M,| Smith PH,| Edsmyr F |(eds) Bladder tumors and other topics in urological oncology. Plenum Press, New York, pp 381–385

    Google Scholar 

  • Pavone-Macaluso M, and EORTC Genitourinary Tract Cooperative Group A (1976) Single drug chemotherapy of bladder cancer with adriamycin. VM-26 or bleomycin. A Phase II multicentric cooperative study. Eur Urol 2: 138–141

    Google Scholar 

  • Rodriguez LH, Johnson DE, Holoye PY, Samuels MD (1977) Combination VM-26 and adriamycin for metastatic transitional cell carcinoma. Cancer Treat Rep 61: 187–188

    Google Scholar 

  • Sakamato S, Ogata J, Ikegami K, Naeda H (1978) Effects of systemic administration of neocarsinostatin, a new protein antibiotic on human bladder cancer. Cancer Treat rep 62: 453–454

    Google Scholar 

  • Samuels ML (1979) CISCA combination chemotherapy. In: Johnson DE, Samuels ML (eds) Second Annual Conference on Cancer of the Genitourinary Tract. Raven Press, New York, pp 97–106

    Google Scholar 

  • Schellhammer Pf, Whitmore WF (1976) Transitional cell carcinoma of the urethra in men having cystectomy for bladder cancer. J Urol 115: 56–60

    PubMed  CAS  Google Scholar 

  • Smith JA, Whitmore WF (to be published) Regional lymph node metastases from bladder cancer. J Urol

    Google Scholar 

  • Soloway MS (1978) cis-Diamminedichloroplatinum (II) (DDP) in advanced bladder cancer. J Urol 120: 716–719

    PubMed  CAS  Google Scholar 

  • Soloway MS, Murphy WM (1979) Experimental chemotherapy of bladder cancer-systemic and intravesical. Semin Oncol 6: 166–183

    PubMed  CAS  Google Scholar 

  • Sternberg JJ, Bracken RB, Handel PB, Johnson DE (1977) Combination chemotherapy (Cisca) for advanced urinary tract carcinoma. A preliminary report. JAMA 238: 2282–2287

    Article  CAS  Google Scholar 

  • Turner AG, Hendry WF, Williams GB, Bloom HJG (1977) The treatment of advanced bladder cancer with methotrexate. Br J Urol 49: 673–678

    Article  PubMed  CAS  Google Scholar 

  • Van der Werf Messing B (1975) Carcinoma of the bladder T-3, M-x, N-o treated by pre-operative irradiation followed by cystectomy. Cancer 36: 718–722

    Article  Google Scholar 

  • Whitmore WF (1979) Surgical management of low stage bladder cancer. Semin Oncol 6:207–216

    PubMed  Google Scholar 

  • Williams SD, Donohue JP, Einhorn LH (1979a) Advanced bladder cancer: Therapy with cis-dichloro-diammine platinum (II), adriamycin and 5-fluorouracil. Cancer Treat Rep 63: 1573–1576

    PubMed  CAS  Google Scholar 

  • Williams SD, Einhorn LH, Donohue JP (1979b) cis-Platinum combination chemotherapy of bladder cancer. Cancer Clin Trials 2: 335–338

    PubMed  CAS  Google Scholar 

  • Yagoda A (1977) Future implications of phase 2 chemotherapy trials in ninety-five patients with measurable advanced bladder cancer. Cancer Res 37: 2275–2280

    Google Scholar 

  • Yagoda A (1980) Chemotherapy of metastatic bladder cancer. Cancer 45: 1879–1888

    PubMed  CAS  Google Scholar 

  • Yagoda A, Watson RC, Gonzalez-Vitale JC, Grabstald H, Whitmore W (1976) cis-Dichlorodiammineplatinum (II) in advanced bladder cancer. Cancer Treat Rep 60: 917–923

    PubMed  CAS  Google Scholar 

  • Yagoda A, Watson RC, Grabstald H, Barzell WE, Whitmore WF (1977a) Adriamycin and cyclophosphamide in advanced bladder cancer. Cancer Treat Rep 61: 97–99

    PubMed  CAS  Google Scholar 

  • Yagoda A, Watson RC, Whitmore WF, Grabstald H, Middleman MP, Krakoff IH (1977b) Adriamycin in advanced urinary tract cancer: Experience in 42 patients and a review of the literature. Cancer 39: 279–285

    Article  PubMed  CAS  Google Scholar 

  • Yagoda A, Watson RC, Kemey N, Barzell WE, Grabstald H, Whitmore WF (1978) Diamminedichloride platinum II and cyclophosphamide in the treatment of advanced urothelial cancer. Cancer 41: 2121–2130

    Article  PubMed  CAS  Google Scholar 

  • Yagoda A, Watson RC, Whitmore WF (1980) Phase II trial of methotrexate in bladder cancer. Proc Am Assoc Cancer Res 21: 427

    Google Scholar 

Download references

Authors
  1. A. Yagoda
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Oncology, The Albany Medical College, Albany, New York, 12208, USA

    A. S. D. Spiers MB, BS, MD(Melb.), PhD, FRCPE, FRACP, FACP (Professor of Medicine) (Professor of Medicine)

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Yagoda, A. (1982). Chemotherapy for Advanced Urothelial Tract Tumors. In: Spiers, A.S.D. (eds) Chemotherapy and Urological Malignancy. Clinical Practice in Urology. Springer, London. https://doi.org/10.1007/978-1-4471-1332-4_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-1332-4_6

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1334-8

  • Online ISBN: 978-1-4471-1332-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation