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Effects of “Ageing” on Arterial Cells in Vitro

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Diseases of the Arterial Wall

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Abstract

Current theories relating to the genesis of atherosclerosis assign an important role to smooth-muscle cells. The first stages of this disease consist of a thickening of the intima caused by the proliferation of smooth-muscle cells which have migrated from the media towards the intima [60,61]. According to certain investigators, this stimulation of the growth of smooth-muscle cells, which are usually quiescent in normal arteries, could be explained either by a mutation conferring a selective advantage on a single cell which could then divide upon stimulation [2] or by injury to the intimal barrier causing the smooth-muscle cells to be exposed to circulating serum factors [60], and, in particular, to platelet-derived growth factors which seems to be the principal mitogenic agent for smooth-muscle cells [6,62].

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Authors
  1. Monique Breton
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  2. J. Picard
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Editors and Affiliations

  1. Service d’Anatomie Pathologique et Unité de Recherche sur la Pathologie Rénale et Vasculaire, INSERM U28, Paris, France

    Jean-Pierre Camilleri (Professeur) (Professeur)

  2. Department of Morbid Anatomy, Institute of Pathology, The London Hospital, Whitechapel, London, E1 1BB, UK

    Colin L. Berry (Professor) (Professor)

  3. Service de Médecine Interne et de Pathologie Vasculaire, Hôpital Broussais, Paris, France

    Jean-Noël Fiessinger (Professeur) (Professeur)

  4. Service de Néphrologie et Unité de Recherche sur la Pathologie Rénale et Vasculaire, INSERM U28, Hôpital Broussais, Paris, France

    Jean Bariéty (Professeur) (Professeur)

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© 1989 Springer-Verlag Berlin Heidelberg

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Breton, M., Picard, J. (1989). Effects of “Ageing” on Arterial Cells in Vitro. In: Camilleri, JP., Berry, C.L., Fiessinger, JN., Bariéty, J. (eds) Diseases of the Arterial Wall. Springer, London. https://doi.org/10.1007/978-1-4471-1464-2_5

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  • DOI: https://doi.org/10.1007/978-1-4471-1464-2_5

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