Skip to main content

Non-Curative Chemotherapy for Non-Small Cell Lung Carcinoma

  • Chapter
Cancer: How Worthwhile is Non-Curative Treatment?

Part of the book series: Focus on Cancer ((3292))

  • 38 Accesses

Abstract

Changes in smoking habits in the UK and other Western communities are resulting in a decline in the incidence of lung cancer among men in recent years. In women it is still increasing (for the same reason). In many parts of the developing world tobacco consumption is growing, and an epidemic of lung cancer, similar to the one which affected Europe and North America in the second half of this century, will doubtless follow. There is little evidence that political intervention, on the scale required, will significantly influence these trends. So lung cancer is destined to remain the biggest cancer problem worldwide for the foreseeable future, with moe than half a million new cases diagnosed annually [1]. Approximately 80% of these tumours are of non-small cell histological type, including squamous, adeno- and large cell carcinomas.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Parkin DM, Saxo AJ (1993) Lung cancer: worldwide variation in occurrence and proportion attributed to tobacco use. Lung Cancer (suppl) 9:1–16.

    Article  Google Scholar 

  2. Squires TS, Tong T (1993) Cancer statistics. CA Cancer J Clin 43:7–26.

    Article  PubMed  Google Scholar 

  3. Rudd R (1991) Chemotherapy in the treatment of non-small cell lung cancer. Resp Dis Prac 7:12–15.

    Google Scholar 

  4. Berry RJ, Laing AH, Newman CR, Peto J (1977) The role of radiotherapy in treatment of inoperable lung cancer. Int J Radiat Oncol Biol Phys 2:433–439.

    Article  PubMed  CAS  Google Scholar 

  5. Roswit B, Patno ME, Rapp R et al. (1968) The survival of patients with inoperable lung cancer: a large-scale randomized study of radiation therapy versus placebo. Radiology 90:688–697.

    PubMed  CAS  Google Scholar 

  6. Johnson DH, Einhorn LH, Bartolucci A et al. (1990) Thoracic radiotherapy does not prolong survival in patients with locally advanced, unresectable non-small cell lung cancer. Ann Intern Med 113:33–38.

    PubMed  CAS  Google Scholar 

  7. Perez CA, Pajak TF, Rubin P et al. Long-term observations of the patterns of failure in patients with unresectable non-oat cell carcinoma of the lung treated with definitive radiotherapy. Report by the Radiation Therapy Oncology Group. Cancer 59:1874–1881.

    Google Scholar 

  8. Einhorn LH, Loehrer PJ, Williams SD et al. (1986) Random prospective study of vindesine versus vindesin plus high-dose cisplatin versus vindesine plus cisplatin plus mitomycin C in advanced non-small-cell lung cancer. J Clin Oncol 4:1037–1043.

    PubMed  CAS  Google Scholar 

  9. Kris M, Cohen E, Gralla R (1985) An analysis of 134 phase II trials in non-small cell lung cancer (NSCLC) (Abstr). Proc of the IV World Conf on Lung Cancer, Toronto, 4:39.

    Google Scholar 

  10. Cullen MH (1983) Acceptable damage to normal tissue. In: Stoll B (ed) Cancer treatment: end-point evaluation. Wiley, Chichester, 139–171.

    Google Scholar 

  11. Watanabe Y, Shimizu J, Oda M et al. (1991) Aggressive surgical intervention in N2 non-small cell cancer of the lung. Ann Thorac Surg 51:253–261.

    Article  PubMed  CAS  Google Scholar 

  12. Martini N, Flehinger BJ (1987) The role of surgery in N2 lung cancer. Surg Clin North Am 67:1037–1049.

    PubMed  CAS  Google Scholar 

  13. Mountain CF (1990) Expanded possibilities for surgical treatment of lung cancer: survival in stage IIIA disease. Chest 97:1045–1051.

    Article  PubMed  CAS  Google Scholar 

  14. Naruke T, Goya T, Tsuchyia R, Suemasu K (1988) The importance of surgery to nonsmall cell carcinoma of lung with mediastinal lymph node metastasis. Ann Thorac Surg 46:603–610.

    Article  PubMed  CAS  Google Scholar 

  15. Rosell R, Gomez-Codina J, Camps C, Maestre J, Padille J, Canto A, Mate JL, Li S, Roig J, Olazabal A, Canela M, Ariza A, Skacel Z, Morera-Prat J, Abad A (1994) A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer. N Engl J Med 330:153–158.

    Article  PubMed  CAS  Google Scholar 

  16. Roth JA, Fosella F, Komaki R, Ryan MB, Putnam JB, Lee JS, Dhingra H, De Caro L, Chasen M, McGavran M, Atkinson EN, Hong WK (1994) A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage III non-small cell lung cancer. J Natl Cancer Inst 86:673–680.

    Article  PubMed  CAS  Google Scholar 

  17. Peto R (1987) Why do we need systematic overviews of randomised trials? Stat Med 6:233–240.

    Article  PubMed  CAS  Google Scholar 

  18. Stewart LA, Pignon JP, Parmar MKB, Arriagada R, Souhami RL on behalf of the NSCLC Collaborative Group (1994) A meta-analysis of adjuvant chemotherapy in non-small cell lung cancer (NSCLC) using updated individual patient data. Lung Cancer II (suppl 2): 49–50.

    Google Scholar 

  19. Cullen MH, Joshi R, Chetiyawardana AD, Woodroffe CM (1988) Mitomycin, ifosfamide and cisplatin in non-small cell lung cancer: treatment good enough to compare. Br J Cancer 58:359–361.

    Article  PubMed  CAS  Google Scholar 

  20. Cullen MH (1994) Trials of radical radiotherapy versus chemotherapy plus radical radiotherapy in non-small cell lung cancer. Semin Oncol 21(3 suppl 4):34–41.

    PubMed  CAS  Google Scholar 

  21. Schaake-Koning C, Van Den Bogaert W, Dalesio O et al. (1992) Effects of concomitant cisplatin and radiotherapy on inoperable non-small cell lung cancer. N Engl J Med 326(8):524–530.

    Article  PubMed  CAS  Google Scholar 

  22. Le Chevalier T, Arriagada R, Quoix E et al. (1991) Radiotherapy alone versus combined chemotherapy and radiotherapy in unresectable non-small cell lung carcinoma. J Natl Cancer Inst 83:417–423.

    Article  PubMed  Google Scholar 

  23. Le Chevalier T, Arriagada R, Quoix E et al. (1991) Impact of chemotherapy (CT) on survival of locally advanced non-small-cell lung cancer (NSCLC): results of a randomized study in 353 pts (Abstr). Lung Cancer 7(suppl):159.

    Google Scholar 

  24. Dillman RO, Seagren SL, Propert KJ et al. (1990) A randomized trial of induction chemotherapy plus high dose radiation versus radiation alone in stage III non-small cell lung cancer. N Engl J Med 323:940–945.

    Article  PubMed  CAS  Google Scholar 

  25. Souhami RL, Spiro SG, Cullen MH (1991) Chemotherapy and radiation therapy as compared with radiation therapy in stage III non-small-cell cancer. N Engl J Med 324:1136.

    Article  PubMed  CAS  Google Scholar 

  26. Sause W, Scott C, Taylor S, Johnson D, Livingston R, Komaki R, Emami B, Curran W, Byhardt R, Fisher G, Turrisi A (1994) RTOG 8808 ECOG 4588, preliminary analysis of a phase III trial in regionally advanced unresectable non-small cell lung cancer. Lung Cancer II (suppl 1):179.

    Google Scholar 

  27. Arriagada R, Stewart LA, Pignon JP, Souhami RL, LeChevalier T on behalf of the NSCLC Collaborators Group (NSCLCCG) (1994) Combined radio-chemotherapy in the management of locally advanced non-small cell lung cancer (NSCLC). Lung Cancer II (suppl 2):146–147.

    Google Scholar 

  28. Souhami RL, Stewart LA, Arriagada R, Parmar MKB, Le Chevalier T, Pignon JP (1994) A data-based meta-analysis of randomised trials of chemotherapy versus best supportive care (BSC) in advanced non-small cell lung cancer (NSCLC). Lung Cancer II (suppl 2):24–25.

    Article  Google Scholar 

  29. Slevin, M, Stubbs L, Plant HJ, et al. (1990) Attitudes to chemotherapy, comparing views of patients with cancer with those of doctors, nurses, and general public. Br Med J 300:1458–1460.

    Article  CAS  Google Scholar 

  30. Hardy JR, Noble T, Smith IE (1989) Symptom relief with moderate dose chemotherapy (mitomycin-C, vinblastine and cisplatin) in advanced non-small cell lung cancer. Br J Cancer 60:764–766.

    Article  PubMed  CAS  Google Scholar 

  31. Green MR (1991) Unresectable stage III non-small-cell lung cancer: lessons and directions from clinical trials research. J Natl Cancer Inst 83:382.

    Article  PubMed  CAS  Google Scholar 

  32. Cullen MH, Billingham LJ, Dunn J (1997) Abstract 8. Lung Cancer 18 (suppl 1):4.

    Article  Google Scholar 

  33. Cullen MH, Billingham LJ, Woodroffe CM, Gower N, Souhami RL, Chetiyawardana AD, Joshi R, Rudd R, Trask C, Spiro S (1997) Abstract 10. Lung Cancer 18 (suppl 1):5.

    Google Scholar 

  34. Cullen MH, Woodroffe CM, Billingham LJ, Chetiyawardana AD, Joshi R, Ferry D, Connolly CK, Bessell E (1997) Abstract 11. Lung Cancer 18 (suppl 1):5.

    Google Scholar 

  35. Billingham LJ, Cullen MH, Woods BW, Chetiyawardana AD, Joshi R, Cook J, Woodroffe CM (1997) Abstract 26. Lung Cancer 18 (suppl 1):9.

    Article  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer-Verlag London Limited

About this chapter

Cite this chapter

Cullen, M.H. (1998). Non-Curative Chemotherapy for Non-Small Cell Lung Carcinoma. In: Slevin, M.L., Tate, T. (eds) Cancer: How Worthwhile is Non-Curative Treatment?. Focus on Cancer. Springer, London. https://doi.org/10.1007/978-1-4471-1509-0_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-1509-0_16

  • Publisher Name: Springer, London

  • Print ISBN: 978-3-540-76083-2

  • Online ISBN: 978-1-4471-1509-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics