Abstract
Individual variation of homeostatic response to hypoxia has been recognized by investigators from the former Soviet Union as well as Western countries. The proven influence of both hereditary and environmental parameters on physiological responses must drive the selection of individual regimes for athletic training, disease treatment, and outcome prognostication. Our longitudinal examinations of identical twins both at sea level and altitudes have shown that the ventilatory response to hypoxic stimulus is a rigid, genetically determined, physiological characteristic reflecting an organism’s overall nonspecific reactivity. On the basis of our twin investigations, we have designed a nomogram to estimate individual nonspecific reactivity and functional reserves for prognosis of subject adaptation to hypoxia. Various strategies of adaptation were identified for persons with differing hypoxic ventilatory sensitivity. Intermittent hypoxic training (IHT) regimes can be customized to match this known individual reactivity. Mechanisms that mediate interindividual variation of adaptation to hypoxia were primarily determined by making measurements in animals with high (HR) and low (LR) resistance to acute hypoxia. Although there are several possible causes for such variation, much of the interest in Russian/Ukraine has focused on mitochondria. The researchers found that, when compared to LR rats, HR rats had: (1) greater mitochondrial enzyme complex I activity, (2) increased nitric oxide inhibition of Ca2+-ATPase activity with concomitant decreased intracellular Ca2+, (3) enhanced antioxidant activity, and (4) increased gene expression. Differential selective oxidation of two Krebs cycle substrates, alpha-ketoglutarate versus succinate, acts more intensively in HR animals, thereby enhancing cholinergic status. Our investigations have shown that l-arginine injections as well as IHT increase mitochondrial calcium capacity in LR rats to the same level as HR rats. Mitochondrial ATP-dependent potassium channel openers affected mitochondrial respiration differently in HR and LR rats. These differences were similar to the IHT effects. Nevertheless, there is a continued search for potential universal marker(s) for individual prognosis of adaptation to hypoxia. Future investigations will shed light on this very important question. Collectively, we can envisage a bright future for individualized IHT, which may play a significant role in the fast-developing field of personalized preventive medicine against various human diseases.
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Abbreviations
- CIS:
-
Commonwealth of Independent States
- EPO:
-
Erythropoietin
- HCVR:
-
Hypercapnic ventilatory sensitivity
- HIF-1:
-
Hypoxia-inducible factor 1
- HR:
-
High resistant
- HVR:
-
Hypoxic ventilatory response
- IHT:
-
Intermittent hypoxic training
- LHTL:
-
Live high-train low
- LR:
-
Low resistant
- mKATP :
-
Mitochondrial ATP-dependent potassium channels
- MR:
-
Medium resistant
- NO:
-
Nitric oxide
- VO2max:
-
Maximal oxygen uptake
References
Abrahams E, Silver M. The case for personalized medicine. J Diabetes Sci Technol. 2009;3:680–4.
Agadzhanyan NA, Mirrakhimov MM. Mountains and resistance. Moscow: Nauka Publishers; 1970 [In Russian].
Agadzhanyan NA. Adaptation and an organism’s reserves. Moscow: Fizkultura i Sport; 1983 [In Russian].
Aidaraliev AA, Maksimov AL. Human adaptation to extreme conditions. The experience of prognosis. Leningrad: Nauka; 1988 [In Russian].
Aidaraliev AA, Maksimov AL, Chernook TB. Adaptation capabilities of polar explorers in Antarctic mountains. Kosm Biol Aviakosm Med. 1987;21(6):62–6 [In Russian].
Aydaraliev AA, Maksimov AL. Physical capacity estimation in the mountains. Methodical recommendations. Moscow: Nauka; 1980 [In Russian].
Aydaraliev A, Baevsky R, Berseneva T, et al. A framework for evaluating an organism’s functional reserves. Frunze: Ilim; 1988. 195 pp [In Russian].
Baevsky RM. Prognosis of the body’s position between normal and pathological condition. Moscow: Meditsina; 1979 [In Russian].
Baevsky RM. Principals of astronauts’ health predictions and results of prognostic examinations during prolonged space expeditions. In: Physiological investigations of imponderability. Moscow: Nauka; 1983. p. 200–28 [In Russian].
Berezovski VA, Boyko КA, Klimenko КC, et al. Hypoxia and individual peculiarities of reactivity. Kiev: Nfukova Dumka; 1978 [In Russian].
Berezovski VA, Serebrovskaia TV. Ventilatory response to a hypercapnic stimulus as an index of the reactivity of the human respiratory system. Fiziol Zh. 1987;33(3):12–8 [In Ukrainian].
Berezovskii VA, Levashov MI. The build-up of human reserve potential by exposure to intermittent normobaric hypoxia. Aviakosm Ekolog Med. 2000;34(2):39–43 [In Russian].
Berezovskii VA, Serebrovskaia TV. Individual reactivity of the human respiratory system and its evaluation. Fiziol Zh. 1988; 34(6):3–7 [In Russian].
Berezovskii VA, Serebrovskaia TV, Ivashkevich AA. Various individual features of human adaptation to altitude. Kosm Biol Aviakosm Med. 1987;21(1):34–7 [In Russian].
Berezovskii VA, Serebrovskaia TV, Lipskii PI. Respiratory function in twins under different gas mixtures. Fiziol Zh. 1981;27(1):20–5 [In Russian].
Berezovsky VA, editor. Hypoxia: individual sensitivity and reactivity. Kiev: Naukova Dumka; 1978 [In Russian].
Bernardi L, Passino C, Serebrovskaya Z, Serebrovskaya T, Appenzeller O. Respiratory and cardiovascular adaptations to progressive hypoxia. Effect of interval hypoxic training. Eur Heart J. 2001;22:879–86.
Bhaumik G, Sharma RP, Dass D, et al. Changing hypoxic ventilatory responses of men and women 6 to 7 days after climbing from 2100 m to 4350 m altitude and after descent. High Alt Med Biol. 2003;4:341–8.
Bolmont B, Bouquet C, Thullier F. Relationships of personality traits with performance in reaction time, psychomotor ability, and mental efficiency during a 31-day simulated climb of Mount Everest in a hypobaric chamber. Percept Mot Skills. 2001;92:1022–30.
Burov A. System for valuation of the operators professional aging rates. Human factors in organizational design and management-VI. In: Proceedings of the sixth international symposium on human factors in organizational design and management. Hague, Netherlands; 19–22 Aug 1998.
Burtscher M, Bachmann O, Hatzl T, et al. Cardiopulmonary and metabolic responses in healthy elderly humans during a 1-week hiking programme at high altitude. Eur J Appl Physiol. 2001;84:379–86.
Bushov IuV, Makhnach AV, Protasov KT. Analysis of individual differences of psychological reactions to combined hypoxic exposure. Fiziol Cheloveka. 1993;19:97–103 [In Russian].
Chan IS, Ginsburg GS. Personalized medicine: progress and promise. Annu Rev Genomics Hum Genet. 2011;12:217–44.
Chapman RF, Stray-Gundersen J, Levine BD. Individual variation in response to altitude training. J Appl Physiol. 1998;85:1448–56.
Chapman RF, Stray-Gundersen J, Levine BD. Epo production at altitude in elite endurance athletes is not associated with the sea level hypoxic ventilatory response. J Sci Med Sport. 2010;13:624–9.
Collins DD, Scoggin CH, Zwillich CW, et al. Hereditary aspects of decreased hypoxic response. J Clin Invest. 1978;62:105–10.
Deindl E, Kolar F, Neubauer E, et al. Effect of intermittent high altitude hypoxia on gene expression in rat heart and lung. Physiol Res. 2003;52:147–57.
Dembo AR, Zemtsovski EV, Frolov BA. Echocardiogram and correlative rhythmography in sport. Leningrad: Nauka; 1979 [In Russian].
Eckes L. Altitude adaptation. Part III. Altitude acclimatization as a problem of human biology. Gegenbaurs Morphol Jahrb. 1976; 122:535–69 [In German].
Edmunds NJ, Moncada S, Marshall JM. Does nitric oxide allow endothelial cells to sense hypoxia and mediate hypoxic vasodilatation? in vivo and in vitro studies. J Physiol. 2003;546:521–7.
Egorov PI. Effect of high altitude flight on a pilot’s body systems. Moscow: Medgiz; 1937 [In Russian].
Gurvich HE. Influence of high-altitudes on an organism. In: Krotkov FG, editor. Physiology and hygiene of high-altitude flights. Moscow-Leningrad: State Publishing House of the Biological and Medical Literature; 1938. p. 17–24 [In Russian].
Henry Y, Guissani A. Interactions of nitric oxide with hemoproteins: roles of nitric oxide in mitochondria. Cell Mol Life Sci. 1999;55:1003–14.
Hochachka PW, Rupert JL. Fine tuning the HIF-1 ‘global’ O2 sensor for hypobaric hypoxia in Andean high-altitude natives. Bioessays. 2003;25:515–9.
Hopfl G, Ogunshola O, Gassmann M. Hypoxia and high altitude. The molecular response. Adv Exp Med Biol. 2003;543:89–115.
Kawakami Y, Yamamoto H, Yoshikawa T, et al. Chemical and behavioral control of breathing in adult twins. Am Rev Respir Dis. 1984;129:703–7.
Kaznacheev VP, Baevsky RM, Berseneva AP. Prenosological diagnostics during screening tests of a specific human population. Leningrad: Nauka; 1980 [In Russian].
Kolchinskaya AZ. Mechanisms of interval hypoxic training effects. Hypoxia Med J. 1993;1:5–7.
Kolchinskaya AZ, Hatsukov BH, Zakusilo MP. Oxygen insufficiency: destructive and constructive actions. Nalchik: Kabardino-Balkaria Scientific Center; 1999 [In Russian].
Kurhaliuk NM. State of mitochondrial respiration and calcium capacity in livers of rats with different resistance to hypoxia after injections of L-arginine. Fiziol Zh. 2001;47:64–72 [In Ukrainian].
Kurhalyuk NM, Serebrovskaya TV, Kolesnikova EE. Role of cholino- and adrenoreceptors in regulation of rat antioxidant defense system and lipid peroxidation during adaptation to intermittent hypoxia. Probl Ecol Med Genet Cell Immunol, Kiev-Lugansk-Kharkiv. 2001;7(39):126–37 [In Ukrainian].
Kurhalyuk NM. Role of L-arginine on guinea pigs mitochondrial respiration in myocardium under acute hypoxia. Bull L’viv Univ ser Biol. 2002;29:177–86 [In Ukrainian].
Lapshin AV, Manukhina EB, Meerson FZ. Adaptation to short stress exposures prevents the enhancement of the endothelium-dependent reactions of the aorta in myocardial infarct. Fiziol Zh SSSR Im I M Sechenova. 1991;77(3):70–8 [In Russian].
Levine BD, Stray-Gundersen J. Dose-response of altitude training: how much altitude is enough? Adv Exp Med Biol. 2006;588:233–47.
Luk’ianova LD. Molecular mechanisms of tissue hypoxia and organism adaptation. Fiziol Zh. 2003;49(3):17–35 [In Russian].
Lukyanova LD. Molecular, metabolic and functional mechanisms of individual resistance to hypoxia. In: Sharma BK, Takeda N, Ganguly NK, et al., editors. Adaptation biology and medicine. New Dehli: Narosa Publishing House; 1997. p. 236–50.
Lukyanova LD, Korablev AV. Some physiological and metabolic characteristics of an animal’s individual resistance to hypoxia. In: Proceedings of the third Soviet Union conference of adaptation. Moscow; 1982. p. 73–6.
Lukyanova LD, Dudchenko AV, Germanova EL, et al. Mitochondrial signaling in formation of body resistance to hypoxia. In: Xi L, Serebrovskaya TV, editors. Intermittent hypoxia: from molecular mechanisms to clinical applications. New York: Nova; 2009. p. 391–417.
Lysenko GI, Serebrovskaya TV, Karaban IN, et al. Use of the method of gradually increasing normobaric hypoxia in medical practice. Methodical recommendations. Kiev: Ukrainian Ministry of Healthcare; 1998 [In Ukrainian].
Maidikov YL, Makarenko NV, Serebrovskaya TV. Human mental activity during high altitude adaptation. Pavlov’s J Higher Nerv Act (USSR). 1986;36(1):12–9.
Makarenko NV. Psychophysiological human functions and operator’s work. Kiev: Naukova Dumka; 1991 [In Russian].
Malkin VB, Gora EP. Participation of respiration in rhythmic interactions in the body. Usp Fiziol Nauk. 1996;27(2):61–77 [In Russian].
Mankovska I, Bakunovsky O, Vargatiy C. Oxygen-transport systems in humans at rest and during physical work after a long-term wintering sojourn at Ukrainian Antarctic station “Academician Vernadsky”. In: Proceeding of the 2nd Ukrainian Antarctic conference. Kiev; 22–24 June 2004. p. 11 [In Ukrainian].
Medvedev VI. Constancy of human physiological and pathological functions under extreme conditions. Leningrad: Nauka; 1982 [In Russian].
Mirrakhimov MM, Khamzamulin RO, Ragozin ON. Features of the ECG in acute altitude sickness. Kardiologiia. 1986;26(2):32–4 [In Russian].
Mirrakhimov MM, Aidaraliev AA, Maksimov AL. Prognostic aspects of physical activity at high altitudes. Frunze: Ilim; 1983 [In Russian].
Moore LG. Comparative human ventilatory adaptation to high altitude. Respir Physiol. 2000;121:257–76.
Navakatikyan AO, Kapshuk AP. Mathematical analysis of heart rhythm during work of different intensity. In: Mathematical methods of research planning, data analysis and prognosis in hygiene. Kiev: Zdorov’e; 1977. p. 34–41 [In Russian].
Negoescu R, Filcescu V, Boanta F, et al. Hypobaric hypoxia: dual sympathetic control in the light of RR and QT spectra. Rom J Physiol. 1994;31:47–53.
Nicolas M, Thullier-Lestienne F, Bouquet C, et al. A study of mood changes and personality during a 31-day period of chronic hypoxia in a hypobaric chamber (Everest-Comex 97). Psychol Rep. 2000;86:119–26.
Noel-Jorand MC, Joulia F, Braggard D. Personality factors, stoicism and motivation in subjects under hypoxic stress in extreme environments. Aviat Space Environ Med. 2001;72:391–9.
Rozenblyum DE. Adaptation to oxygen deficiency in short-term, repetitive exposure to low barometric pressure. Bull Exp Biol Med. 1943;21(7–8):6–9 [In Russian].
Semenza GL. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol. 2000;88:1474–80.
Serebrovskaia TV. Hereditary defect of sensitivity to hypoxia in normal sensitivity to hypercapnia. Patol Fiziol Eksp Ter. 1982;4:80–3 [In Russian].
Serebrovskaia TV, Ivashkevich AA, Maidikov IL. The relation of the reactivity of the human respiratory system, mental and physical work capacity and metabolic characteristics during a 1-year stay in the mountains. Fiziol Zh. 1989;35(4):61–9 [In Russian].
Serebrovskaia TV, Lipskii PI. Levels of hereditary determination of human cardiorespiratory system functional indices. Fiziol Zh. 1982;28(3):267–73 [In Russian].
Serebrovskaya TV, Kurhalyuk NM, Nosar VI, et al. Combination of intermittent hypoxic training with exogenous nitric oxide treatment improves rat liver mitochondrial oxidation and phosphorilation under acute hypoxia. Fiziol Zh. 2001;47(1):85–92 [In Ukrainian].
Serebrovskaya TV. Intermittent hypoxia research in the former Soviet Union and the Commonwealth of Independent States (CIS): history and review of the concept and selected applications. High Alt Med Biol. 2002;3:205–21.
Serebrovskaya TV, Kurhalyuk NM, Moibenko AA et al. Effects of mitochondrial KATP stimulation on myocardial energy supply in rats with different resistance to hypoxia. In: Proceedings of the 5th international conference “Hypoxia in Medicine”, Innsbruk; 2003. Hypoxia Medical J. 2003; 3:36.
Shakhtarin VV, Kiriachkov IuIu, IaM K, et al. The autonomic reaction of the body to stress and its prognostic value. Vestn Akad Med Nauk SSSR. 1990;3:33–7 [In Russian].
Shen C, Powell-Coffman JA. Genetic analysis of hypoxia signaling and response in C. elegans. Ann N Y Acad Sci. 2003;995:191–9.
Sirotinin NN. Effect of acclimatization to high mountain climate on adaptation to decreased atmospheric pressure using a decompression chamber. Arkh Pat Anat Pat Physiol. 1940;6:35–42 [In Russian].
Streltsov VV. Physiological validation of decompression chamber training for high altitude flights. Abstract of report at the All-Union conference on aerospace medicine. Leningrad; 1939. p. 18 [In Russian].
Tsvetkova AM, Tkatchouk EN. “Hypoxia user”: the opportunity of individual programming of interval hypoxic training. In: Hypoxia: mechanisms, adaptation, correction. Moscow: BEBIM; 1999. p. 83–4.
Vasin MV, Petrova TV, Bobrovnitskii IP, et al. Human biochemical status and its relation to body resistance when exposed to acute hypoxic hypoxia. Aviakosm Ekolog Med. 1992;26(5–6):43–9 [In Russian].
Vogt M, Billeter R, Hoppeler H. Effect of hypoxia on muscular performance capacity: “living low-training high”. Ther Umsch. 2003;60:419–24 [In German].
Waters KA, Gozal D. Responses to hypoxia during early development. Respir Physiol Neurobiol. 2003;136:115–29.
Weil JV. Variation in human ventilatory control: genetic influence on the hypoxic ventilatory response. Respir Physiol Neurobiol. 2003;135:239–46.
Zagryadsky VP. Selected lectures on physiology during military labor. Leningrad: Nauka; 1972 [In Russian].
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Serebrovskaya, T.V., Xi, L. (2012). Individualized Intermittent Hypoxia Training: Principles and Practices. In: Xi, L., Serebrovskaya, T. (eds) Intermittent Hypoxia and Human Diseases. Springer, London. https://doi.org/10.1007/978-1-4471-2906-6_23
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