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The Immunobiology of Transplant Rejection and Acceptance

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Transplantation Surgery

Part of the book series: Springer Specialist Surgery Series ((SPECIALIST))

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Abstract

The immune system identifies and attempts to destroy all cells and tissues recognized as foreign. Only tissues from genetically identical donors are exempt, because they do not express foreign antigens that can initiate a response. Even the smallest disparity, a single amino acid in a MHC molecule, can bring about skin transplant rejection in a mouse. The transplantation barrier can be defined in terms of the genetic difference between the donor and recipient, and this will be explained.

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Further Reading

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Authors
  1. Ian V. Hutchinson
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Editor information

Editors and Affiliations

  1. St Mary’s Hospital, Praed Street, W2 1NY, London, UK

    Nadey S. Hakim MD, PhD, FRCS, FRCSI, FACS, FICS (Consultant General and Transplant Surgeon, Surgical Director Transplant Unit) (Consultant General and Transplant Surgeon, Surgical Director Transplant Unit)

  2. Kidney & Pancreas Transplant Programs, BH-427 Center for the Health Sciences, UCLA School of Medicine, Box 951796, 90095-1796, Los Angeles, CA, USA

    Gabriel M. Danovitch MD (Professor of Medicine) (Professor of Medicine)

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© 2001 Springer-Verlag London

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Hutchinson, I.V. (2001). The Immunobiology of Transplant Rejection and Acceptance. In: Hakim, N.S., Danovitch, G.M. (eds) Transplantation Surgery. Springer Specialist Surgery Series. Springer, London. https://doi.org/10.1007/978-1-4471-3689-7_4

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  • DOI: https://doi.org/10.1007/978-1-4471-3689-7_4

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84996-859-1

  • Online ISBN: 978-1-4471-3689-7

  • eBook Packages: Springer Book Archive

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