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Metabonomics in Clinical Practice

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Metabonomics and Gut Microbiota in Nutrition and Disease

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

Abstract

Metabonomics is recognized as a powerful top-down system biology approach to understand genetic-environment-health paradigm paving new avenues to identify clinically relevant biomarkers. It is nowadays commonly used in clinical applications shedding new light on physiological regulatory processes of complex mammalian systems as regards disease etiology, diagnostic stratification, and potentially mechanism of action of therapeutic solutions. It therefore offers opportunities to associate complex metabolic regulations to the etiology of multifactorial diseases and metabolic dysfunctions, which may subsequently lead to mechanistic hypotheses and targets for new nutritional concepts. This review aims at describing recent applications of metabonomics in clinical fields with insight into diseases diagnostics/monitoring and improvement of homeostasis metabolic regulation.

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Authors and Affiliations

  1. Molecular Biomarkers, Nestlé Institute of Health Sciences, EPFL Innovation Park, bâtiment H, 1015, Lausanne, Switzerland

    Sebastiano Collino & François-Pierre Martin

  2. Natural Bioactives and Screening, Nestlé Institute of Health Sciences, EPFL Innovation Park, bâtiment H, 1015, Lausanne, Switzerland

    Sofia Moco

Authors
  1. Sebastiano Collino
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  2. François-Pierre Martin
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  3. Sofia Moco
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Correspondence to Sebastiano Collino .

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Editors and Affiliations

  1. Analytical Sciences Competence Pillar, Nestec SA, Nestlé Research Center, Lausanne, Switzerland

    Sunil Kochhar

  2. Molecular Biomarkers, Nestlé Institute of Health Sciences, Lausanne, Switzerland

    François-Pierre Martin

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Collino, S., Martin, FP., Moco, S. (2015). Metabonomics in Clinical Practice. In: Kochhar, S., Martin, FP. (eds) Metabonomics and Gut Microbiota in Nutrition and Disease. Molecular and Integrative Toxicology. Springer, London. https://doi.org/10.1007/978-1-4471-6539-2_2

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