Abstract
Epithelioid hemangioma is a special type of hemangioma characterized by a benign although locally aggressive behavior, composed by proliferated small-caliber blood vessels lined by plump endothelial cells with an epithelioid morphology. It is rare in bone, where it grows in a more solid fashion than its soft tissue counterpart. It is seen more often between 20 and 60 years of age. Long bones of the extremities are preferably affected and may be multifocal. EH is usually painful. Regional lymph node metastases and soft tissue extension of the tumor do not mean altered aggressiveness. Besides endothelial markers, epithelial markers are positive. It has a 10 % recurrence risk.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Recommended Reading
Boyaci B, Hornicek FJ, Nielsen GP, DeLaney TF, Pedlow Jr FX, Mansfield FL, Carrier CS, Harms J, Schwab JH. Epithelioid hemangioma of the spine: a case series of six patients and review of the literature. Spine J. 2013;13(12):e7–13.
Errani C, Vanel D, Gambarotti M, Alberghini M, Picci P, Faldini C. Vascular bone tumors: a proposal of a classification based on clinicopathological, radiographic and genetic features. Skeletal Radiol. 2012a;41(12):1495–507.
Errani C, Zhang L, Panicek DM, Healey JH, Antonescu CR. Epithelioid hemangioma of bone and soft tissue: a reappraisal of a controversial entity. Clin Orthop Relat Res. 2012b;470(5):1498–506. doi:10.1007/s11999-011-2070-0. PubMed PMID: 21948309, PubMed Central PMCID: PMC3314752, Epub 2011 Sep 24.
Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, editors. WHO classification of tumors of soft tissue and bone. 4th ed. Lyon: IARC Press; 2013.
Hart JL, Edgar MA, Gardner JM. Vascular tumors of bone. Semin Diagn Pathol. 2014;31:30–8.
Sirikulchayanonta V, Jinawath A, Jaovisidha S. Epithelioid hemangioma involving three contiguous bones: a case report with a review of the literature. Korean J Radiol. 2010;11(6):692–6.
Verbeke SL, Bovée JV. Primary vascular tumors of bone: a spectrum of entities? Int J Clin Exp Pathol. 2011;4(6):541–51.
Ye C, Pan L, Huang Y, Ye R, Han A, Li S, Li X, Wang S. Somatic mutations in exon 17 of the TEK gene in vascular tumors and vascular malformations. J Vasc Surg. 2011;54(6):1760–8.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer-Verlag London
About this chapter
Cite this chapter
Kalil, R.K. (2015). Epithelioid Hemangioma. In: Santini-Araujo, E., Kalil, R., Bertoni, F., Park, YK. (eds) Tumors and Tumor-Like Lesions of Bone. Springer, London. https://doi.org/10.1007/978-1-4471-6578-1_33
Download citation
DOI: https://doi.org/10.1007/978-1-4471-6578-1_33
Publisher Name: Springer, London
Print ISBN: 978-1-4471-6577-4
Online ISBN: 978-1-4471-6578-1
eBook Packages: MedicineMedicine (R0)