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Myogenic Properties of Blood Vessels In Vitro

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The Resistance Vasculature

Part of the book series: Vascular Biomedicine ((VB))

Abstract

It would be a disservice to begin a chapter on the myogenic behavior of blood vessels in vitro without describing the work of Sir William Bayliss almost 90 years ago. Using primitive recording techniques (a smoked drum), he removed a carotid artery from the neck of a dog three hours after asphyxiation, cannulated one end, tied off the other, and filled the segment with defibrinated blood. The preparation was connected to a mercury manometer and, when pressure was elevated, the vessel underwent a powerful contraction and “appeared to writhe like a worm.” Decreasing the pressure produced “considerable relaxation.” Unfortunately, the experimental detail is scant and we have no quantitative measure of the response because, in Bayliss’ words, “I regret that the tracing was spoilt in varnishing, so that I am unable to reproduce it here.”1 Nonetheless, Bayliss’ observation captures the quintessence of myogenic theory as it applies to vascular behavior—pressure orstretch-induced activation of smooth muscle cells that leads to a decrease in arterial diameter.

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References

  1. Bayliss, W. M. (1902) J. Physiol. 28, 220–231.

    PubMed  CAS  Google Scholar 

  2. Garfield, E. (1976) Curr. Contents 19, 5.

    Google Scholar 

  3. Folkow, F. (1964) Circ. Res. 15(Suppl. I), 279–287.

    PubMed  Google Scholar 

  4. Koch, A. R. (1964) Circ. Res.14(Suppl. I), 269–277.

    Google Scholar 

  5. Borgstrom, P., Grande, P.O., and Mellander, S. (1982) Acta Physiol. Scand. 116,363–376.

    Article  PubMed  CAS  Google Scholar 

  6. Lush, D. L. and Fray, J. C. S. (1984) Am. J. Physiol. 247, R89–R99.

    PubMed  CAS  Google Scholar 

  7. Johnson, P. C. (1980) Handbook of Physiology, Section 2: The Cardiovascular System, vol. 2: Vascular Smooth Muscle, (Bohr, D. F., Somlyo, A. P., and Sparks, H. V. J. Jr., eds.), American Physiological Society, Bethesda, MD, pp. 409–442.

    Google Scholar 

  8. Johnson, P. C. (1986) Circ. Res. 59,483–495.

    Article  PubMed  CAS  Google Scholar 

  9. Heistad, D. D. and Kontos, H. A. (1983) Handbook of Physiology, Section 2: The Cardiovascular System, vol. 3,Peripheral Circulation and Organ Blood Flow, Part 2 (Shepherd, J. T. and Abboud, F. M., eds.), American Physiological Society, Bethesda, MD, pp. 137–182.

    Google Scholar 

  10. Bohlen, H. G. and Gore, R. W. (1977) Microvasc. Res. 14,251–264.

    Article  PubMed  CAS  Google Scholar 

  11. Johansson, B. and Mellander, S. (1975) Circ. Res. 36, 76–83.

    Article  PubMed  CAS  Google Scholar 

  12. Laher, I. and Bevan, J. A. (1989) J. Hypertens. 7(Suppl. 4), S17–S20.

    CAS  Google Scholar 

  13. Johanson, B. (1989)1. Hypertens. (Suppl. 4), S5–S8.

    Google Scholar 

  14. Sparks, H. V. (1964) Circ. Res. 14 (Supp1. I), 254–260.

    Google Scholar 

  15. Nakayama, K. (1982) Am. J. Physiol. 242, H760–H768.

    PubMed  CAS  Google Scholar 

  16. Bevan, J. A. (1982) Am. J. Cardiol. 49, 519–524.

    Article  PubMed  CAS  Google Scholar 

  17. Laher, I., van Breemen, C., and Bevan, J. A. (1988) Circ. Res. 63,669–672.

    Article  PubMed  CAS  Google Scholar 

  18. Bevan, J. A. and Hwa, J. J. (1985) Ann. Biomed. Eng. 13, 281–286.

    Article  PubMed  CAS  Google Scholar 

  19. Katusic, Z. S., Shepherd, J. T., and Vanhoutte, P. M. (1987) Am. J. Physiol. 252, H671–H673.

    CAS  Google Scholar 

  20. Uchida, E., Bohr, D. F., and Hoobler, S. W. (1967) Circ. Res. 21,525–536.

    Article  PubMed  CAS  Google Scholar 

  21. Duling, B. R., Gore, R. W., Dacey, R. G., and Damon, D. N. (1981) Am. J. Physiol. 241, H108–H116.

    PubMed  CAS  Google Scholar 

  22. Davignon, J., Lorenz, R. R., and Shepherd, J. T. (1963) Am. J. Physiol. 209, 51–59.

    Google Scholar 

  23. Halpern, W., Osol, G., and Coy, G. S. (1984) Ann. Biomed. Eng. 12, 463–479.

    Article  PubMed  CAS  Google Scholar 

  24. Harder, D. R., Smeda, J., and Lombard, J. (1985) Circ. Res. 57, 319–322.

    Article  PubMed  CAS  Google Scholar 

  25. Uchida, E. and Bohr, D. F. (1969) Circ. Res. 25,549–555.

    Article  PubMed  CAS  Google Scholar 

  26. Osol, G. and Halpern, W. (1985) Am. J. Physiol. 249, H914–H921.

    CAS  Google Scholar 

  27. Vinall, P. E. and Simeone, F. A. (1981) Stroke 12,640–642.

    Article  PubMed  CAS  Google Scholar 

  28. Kuo, L., Chilian, W. M., and Davis, M. J. (1990) Circ. Res. 66,860–866.

    Article  PubMed  CAS  Google Scholar 

  29. Osol, G. and Halpern, W. (1988) Am. J. Physiol. 254, H28–H33.

    PubMed  CAS  Google Scholar 

  30. Osol, G., Osol, R., and Halpern, W. (1986) in Essential Hypertension: Cal-cium Mechanisms and Treatment(Aoki, K., ed.), Springer-Verlag, Tokyo,pp. 107 114.

    Google Scholar 

  31. Nakayama, K., Suzuki, S., and Sugi, H. (1986) Jpn. J. Pysiol. 36, 745–760.

    Article  CAS  Google Scholar 

  32. Davis, M. J. and Burch, L. M (1989) FASEB J. 3, A1383.

    Google Scholar 

  33. Johansson, B. and Bohr, D. F. (1966) Am. J. Physiol. 210, 801–806.

    PubMed  CAS  Google Scholar 

  34. Holman, M. E., Dasby, C. B., Suthers, M. B., and Wilson, J. A. F. (1968) 1. Physiol. (Lond.) 196, 111–132.

    CAS  Google Scholar 

  35. Nelson, M. T., Standen, N. B., Brayden, J. B., and Worley, J. F. (1988) Nature 336,382–385.

    Article  PubMed  CAS  Google Scholar 

  36. Smeda, J. S., Lombard, J. H., Madden, J. A., and Harder, D. R. (1987) Pflugers Arch. 408,239–242.

    Article  PubMed  CAS  Google Scholar 

  37. Harder, D. R. (1984) Circ. Res. 55,197–202.

    Article  PubMed  CAS  Google Scholar 

  38. Harder, D. R., Brann, L., and Halpern, W. (1983) Blood Vessels 20, 154–160.

    PubMed  CAS  Google Scholar 

  39. Hwa, J. J. and Bevan, J. A. (1986) Am. J. Phusiol. 250, H87–H95.

    CAS  Google Scholar 

  40. Rosenblum, W. I. and Nelson, G. H. (1988) Stroke 19,1379–1382.

    Article  PubMed  CAS  Google Scholar 

  41. McCarron, G., Osol, R., and Halpern, W. (1989) Blood Vessels 26, 315–319.

    PubMed  CAS  Google Scholar 

  42. Osol, G., Osol, R., and Halpern, W. (1988) Resistance Arteries (Halpern, W., Pegram, B. L., Brayden, J. E., Mackey, K., McLaughlin, M. K., and Osol, G., eds.), Perinatology, Ithaca, NY, pp. 162–169.

    Google Scholar 

  43. Olesen, S.-P., Clapham, D. E., and Davies, P. F. (1988) Nature 311, 168–170.

    Article  Google Scholar 

  44. Pohl, U., Forstermann, U., Busse, R., and Bassenge, E. (1985) Prostaglandins and Other Eicosanoids in the Cardiovascular System. Proc. 2nd Int. Symp. (Schor, ed.), Nurnberg-Furth, Karger, Basel, pp. 553–558.

    Google Scholar 

  45. Frangos, J. A., Eskin, S. G., McIntire, L. V., and Ives, C. L. (1985) Science 227,1477–1478.

    Article  PubMed  CAS  Google Scholar 

  46. Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K., and Masald, T. (1988) Nature 332, 411–415.

    Article  PubMed  CAS  Google Scholar 

  47. Harder, D. R. (1987) Circ. Res. 60,102–107.

    Article  PubMed  CAS  Google Scholar 

  48. Kauser, K., Stekiel, W. J., Ruganyi, G., and Harder, D. R. (1989) Circ. Res. 65,199–204.

    Article  PubMed  CAS  Google Scholar 

  49. Rubanyi, G. M. (1988) Am. J. Physiol. 255, H783–H788.

    CAS  Google Scholar 

  50. Tesfamariam, B., Halpern, W., and Osol, G. (1985) Blood Vessels 22, 301–305.

    PubMed  CAS  Google Scholar 

  51. Osol, G., Cipolla, M., and Knutson, S. (1989) Blood Vessels 26, 320–324.

    PubMed  CAS  Google Scholar 

  52. Osol, G., Cipolla, M., and Osol, R. (1990) Blood Vessels 27, 51.

    Google Scholar 

  53. Mills, I., Letsou, G., Sumpio, B., and Gewirtz, H. (1989) Circulation 80 (Suppl. II), II-197.

    Google Scholar 

  54. Watson, P. (1990) J. Biol. Chem. 265, 6569–6575.

    PubMed  CAS  Google Scholar 

  55. Laher, I. and Bevan, J. A. (1987) J. Pharmacol. Exp. Ther. 242, 566–572.

    PubMed  CAS  Google Scholar 

  56. Laher, I., Vorkapic, P., Dowd, A., and Bevan, J. A. (1989) Biochem. Biophys. Res. Commun. 165,312--318.

    Article  PubMed  CAS  Google Scholar 

  57. Osol, G., Laher, I., and Cipolla, M. (1991) Circ. Res. 68, 359–367.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. George Osol
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Editors and Affiliations

  1. University of Vermont, Burlington, Vermont, USA

    John A. Bevan  & William Halpern  & 

  2. Aarhus University, Aarhus, Denmark

    Michael J. Mulvany

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© 1991 Springer Science+Business Media New York

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Osol, G. (1991). Myogenic Properties of Blood Vessels In Vitro. In: Bevan, J.A., Halpern, W., Mulvany, M.J. (eds) The Resistance Vasculature. Vascular Biomedicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0403-9_9

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  • DOI: https://doi.org/10.1007/978-1-4612-0403-9_9

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6746-1

  • Online ISBN: 978-1-4612-0403-9

  • eBook Packages: Springer Book Archive

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