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Role of Cytokines in EBV-Infected Cell Growth

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Epstein-Barr Virus and Human Disease · 1990

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 24))

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Abstract

The mechanism of autonomous cell growth of human lymphocytes immortalized by lymphotropic viruses is still poorly understood. In this regard, the transformation of human T lymphocytes by the retrovirus HTLV-I could represent a valuable model. HTLV-I is the causative agent of adult T-cell leukemia (ATL). In vitro, HTLV-I is able to infect CD4+ T lymphocytes, to induce constitutive expression of the p55-Tac-CD25-alpha chain of the IL-2 receptor (IL-2R), and to promote growth of the virally infected T cells. In this process, the role of several viral regulatory proteins is suspected. The p40-tax protein, encoded by the pX region of the virus, is acting as a transcription transactivator element, probably able to interact with the promoter region of cellular genes, encoding growth factor(s) and growth factor receptor(s). Whether some step of this process involves an autocrine loop implying IL-2 and high affinity IL-2R is still a matter of debate.

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Authors and Affiliations

  1. Institut Gustave Roussy, Laboratoire de Biologie des Tumeurs Humaines, URA 1156 CNRS, 94805, Villejuif, France

    T. Tursz, G. Rousselet, P. Busson, Q. Zhang, C. Biguet, B. Mariame, B. Clausse, N. Wakasugi & H. Wakasugi

Authors
  1. T. Tursz
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  2. G. Rousselet
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  3. P. Busson
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  4. Q. Zhang
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  5. C. Biguet
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  6. B. Mariame
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  7. B. Clausse
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  8. N. Wakasugi
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  9. H. Wakasugi
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Editor information

D. V. Ablashi A. T. Huang J. S. Pagano G. R. Pearson C. S. Yang Kristinë L. Ablashi

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© 1991 Springer Science+Business Media New York

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Tursz, T. et al. (1991). Role of Cytokines in EBV-Infected Cell Growth. In: Ablashi, D.V., Huang, A.T., Pagano, J.S., Pearson, G.R., Yang, C.S., Ablashi, K.L. (eds) Epstein-Barr Virus and Human Disease · 1990. Experimental Biology and Medicine, vol 24. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0405-3_21

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  • DOI: https://doi.org/10.1007/978-1-4612-0405-3_21

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6747-8

  • Online ISBN: 978-1-4612-0405-3

  • eBook Packages: Springer Book Archive

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