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Estrogen Receptor Expression in the Pituitary Gland

  • Chapter
Sex-Steroid Interactions with Growth Hormone

Part of the book series: Proceedings in the Serono Symposia USA Series ((SERONOSYMP))

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Abstract

Estradiol has been demonstrated to affect the production or release of all six major anterior pituitary hormones (1–5). Although some of the effects of estradiol on hormonal secretion are primarily hypothalamic in nature, other physiologically relevant actions appear to occur directly within the anterior pituitary gland itself (6–9). According to our current understanding of the signal transduction mechanics of estradiol, the presence of an estrogen receptor (ER) is necessary for such direct actions. This has been the primary rationale for performing experiments to determine which types of anterior pituitary cells express estrogen receptors. By defining which anterior pituitary cells are ER positive, we are identifying which populations of cells possess the necessary cellular machinery to make them at least capable of responding directly to estradiol.

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Authors
  1. Keith E. Friend
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  2. Ian E. McCutcheon
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Editor information

Editors and Affiliations

  1. Division of Endocrinology, Department of Internal Medicine, University of Virginia Health Sciences Center, 22903, Charlottesville, VA, USA

    Johannes D. Veldhuis M.D.

  2. Endocrine Section Department of Internal Medicine, University of Brescia, 25123, Brescia, Italy

    Andrea Giustina M.D.

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© 1999 Springer Science+Business Media New York

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Friend, K.E., McCutcheon, I.E. (1999). Estrogen Receptor Expression in the Pituitary Gland. In: Veldhuis, J.D., Giustina, A. (eds) Sex-Steroid Interactions with Growth Hormone. Proceedings in the Serono Symposia USA Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1546-2_29

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  • DOI: https://doi.org/10.1007/978-1-4612-1546-2_29

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-98810-8

  • Online ISBN: 978-1-4612-1546-2

  • eBook Packages: Springer Book Archive

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