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P2 Receptor Modeling and Identification of Ligand Binding Sites

  • Chapter
The P2 Nucleotide Receptors

Part of the book series: The Receptors ((REC))

Abstract

As of now, seven subtypes of P2X receptors and four subtypes of P2Y receptors have been cloned and functionally identified. Analysis of the predicted amino acid sequences of these structurally diverse subtypes of nucleotide receptors has allowed construction of models that have aided in two- and three-dimensional visualization of P2X and P2Y receptors, respectively. Based on these models and on site-directed mutagenesis studies primarily with P2Y receptors, the ligand binding site of P2 receptors is being delineated. In this chapter, we present the current information on P2X and P2Y receptor structures and discuss the potential for amino acids in these receptors to interact with the nucleotide ligands.

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Authors
  1. A. Michiel van Rhee
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  2. Kenneth A. Jacobson
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  3. Richard Garrad
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  4. Gary A. Weisman
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  5. Laurie Erb
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, University of Missouri-Columbia, MO, USA

    John T. Turner  & Gary A. Weisman  & 

  2. Physiology Section, National Institute for Occupational Safety and Health, Morgantown, WV, USA

    Jeffrey S. Fedan

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© 1998 Springer Science+Business Media New York

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van Rhee, A.M., Jacobson, K.A., Garrad, R., Weisman, G.A., Erb, L. (1998). P2 Receptor Modeling and Identification of Ligand Binding Sites. In: Turner, J.T., Weisman, G.A., Fedan, J.S. (eds) The P2 Nucleotide Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1800-5_6

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  • DOI: https://doi.org/10.1007/978-1-4612-1800-5_6

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-7289-2

  • Online ISBN: 978-1-4612-1800-5

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