Abstract
The succeeding chapters deal with the biochemistry and clinical utilization of cardiac markers. This chapter deals with the source of these markers as they are released into the blood following injury. To appreciate this, a knowledge of cell anatomy at the ultrastructural level is necessary. Over the past 50 yr, two technologies have evolved that have enabled us to understand cell structure by providing details not possible with the light microscope. These investigative tools are the electron microscope (EM*) and X-ray diffraction. The former has elucidated the substructure of muscle fibers as seen with routine histology (or polarizing optics), whereas the latter has given us knowledge about the molecular structure of the muscular contractile apparatus (1,2).
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References
Fawcett DW (1994) Bloom and Fawcett: A Textbook of Histology, Chapman & Hall, New York.
Squire J (1981) The Structural Basis of Muscular Contraction, Plenum Press, New York.
Cormack DH (1993) Essential Histology, J. B. Lippincott Company, Philadelphia, PA.
Junqueira LC et al. (1995) Basic Histology, Appleton & Lange, Stamford, CT.
Ventura-Clapier R, Veksler V, and Hoerter JA (1994) Myofibrillar creatine kinase and cardiac contraction. Mol. Cell Biochem. 133/134:125–144.
Franchi LL, Murdoch A, Brown WE, et al. (1990) Subcellular localisation of newly incorporated myosin in rabbit fast skeletal muscle undergoing stimulation-induced type transformation. J. Musc. Res. Cell. Motil. 11:227–239.
Huxley AF and Nierdergerke R (1954) Structural changes in muscle during contraction. Interference microscopy of living muscle fibers. Nature 173:971–973.
Jorgensen AO, Shen ACY, Campbell KP, and MacClennan DH (1983) Ultrastructural localization of calsequestrin in rat skeletal muscle by immunoferritin labeling of ultrathin frozen selections. J. Cell Biol. 97:1573–1581.
Cuenda A, Nogues M, Gutierrez-Merino C, and de Meis L (1993) Glycogen phospho-rolysis can form a metabolic shuttle to support Ca2+ uptake by sarcoplasmic reticulum membranes in skeletal muscle. Biochem. Biophys. Res. Commun. 196:1127–1132.
Cuenda A, Henao F, Nogues M, and Gutierrez-Merino C (1994) Quantification and removal of glycogen phosphorylase and other enzymes associated with sarcoplasmic reticulum membrane preparations. Biochim. Biophys. Acta. 1194:35–43.
Ganong WF (1995) Review of Medical Physiology, Appleton & Lange, Stamford, CT.
Ebashi S, Endo M, and Ohtsuki I (1969) Control of muscle contraction. Q. Rev. Biophys. 2:351–384.
Block BA, Imagawa T, Campbell KP, and Franzini-Armstrong C (1988) Structural evidence for direct interaction between the molecular components of the transverse tubule/sarcoplasmic reticulum junction in skeletal muscle. J. Cell Biol. 107: 2587–2600.
Goodman, SR (1994) Medical Cell Biology, J. B. Lippincott Company, New York.
Kawai H, Nishino H, Nishida Y, et al. (1987) Localization of myoglobin in human muscle cells by immunoelectron microscopy. Muscle & Nerve 10:144–149.
Widnell CC and Pfenninger KH (1990) Essential Cell Biology, Williams & Wilkins, Baltimore, MD.
Willerson JT (1995) Cardiovascular Medicine, Churchill Livingstone, New York.
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McCord, R.G., Clark, A.W. (1998). Ultrastructure of the Striated Muscle Cell. In: Wu, A.H.B. (eds) Cardiac Markers. Pathology and Laboratory Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1806-7_5
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DOI: https://doi.org/10.1007/978-1-4612-1806-7_5
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4612-7292-2
Online ISBN: 978-1-4612-1806-7
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