Abstract
Activin A, a member of the transforming growth factor- β family, is a homodimer of β A chain and is implicated in the regulation of reproductive endocrine function, erythroid differentiation, mesoderm induction of the Xenopus embryo, and negative cell growth of various cell types including gonadal cells and adrenal cells (1–4). Recently, activin A was independently isolated from cultured media of activated mouse macrophages (5, 6) and mouse bone marrow stromal cells (7) as a factor inhibiting the growth of plasmacytic cells including B-cell hybridoma cells and myeloma cells. The plasmacytic cell growth inhibitory activity of activin A has been shown to be mediated in part by inducing apoptotic cell death (5–8). However, the precise mechanism by which activin A exerts its negative growth effect remains to be elucidated.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Gonzalez-Manchon C, Vale W. Activin A, inhibin and TGF-β modulate growth of two gonadal cell lines. Endocrinology 1989;125:1666–72.
Kojima I, Ogata E. Dual effect of activin on cell growth in Balb/c 3T3 cells. Biochem Biophys Res Commun 1989;159:1107–13.
Spencer SJ, Rabinovici J, Jaffe RB. Human recombinant activin-A inhibits proliferation of human fetal adrenal cells in vitro. J Clin Endocrinol Metab 1990;71:1678–80.
McCarthy S, Bicknell R. Inhibition of vascular endothelial cell growth. J Biol Chem 1993;268:23066–71.
Nishihara T, Okahashi N, Ueda N. Activin A induces apoptotic cell death. Biochem Biophys Res Commun 1993;197:985–91.
Nishihara T, Ohsaki Y, Ueda N, Koseki T, Eto Y. Induction of apoptosis in B lineage cells by activin A derived from macrophages. J Interferon Cytokine Res 1995;15:509–16.
Brosh N, Sternberg D, Honigwachs-Sha’anani J, Lee B-C, Shav-Tal Y, Tzehoval E, et al. The plasmacytoma growth inhibitor restrictin-P is an antagonist of interleukin 6 and interleukin 11. J Biol Chem 1995;270:29594–600.
Koseki T, Yamato K, Krajewski S, Reed JC, Tsujimoto Y, Nishihara T. Activin A-induced apoptosis is suppressed by overexpression of Bcl-2. FEBS Lett 1995;376:247–50.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Yamato, K., Koseki, T., Ohguchi, M., Sugino, H., Nishihara, T. (1997). Induction of G1 Arrest by Activin A via Cooperative Modulation of Cyclin D2 and p21CIP1/WAF1 in Hybridoma Cells. In: Aono, T., Sugino, H., Vale, W.W. (eds) Inhibin, Activin and Follistatin. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1874-6_29
Download citation
DOI: https://doi.org/10.1007/978-1-4612-1874-6_29
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-7320-2
Online ISBN: 978-1-4612-1874-6
eBook Packages: Springer Book Archive