Abstract
Technical limitations of suturing have provided the impetus behind the search for improved methods of providing surgical hemostasis, sealing anastomoses, and bonding tissues. Incompatibility of the suture material with tissues may trigger an inflammatory response, resulting in tissue damage around the suture site. Sutures placed in fragile tissue can lead to necrosis and dehiscence of wounds. Technologies employed to partially overcome these problems include the use of improved suture materials, cauterization, metallic staples or clips, and a variety of adhesive/hemostatic agents. A surgical glue should provide atraumatic and expedient tissue sealing and bonding. The search for the ideal sealant prompted the development of both natural and synthetic products such as fibrin glue, collagen pledgets, absorbable gelatin sponges, oxidized cellulose, and cyanoacrylate derivatives. Fibrin glue is an excellent hemostatic agent as it is readily resorbed and has minimal tissue toxicity.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Tidrick R, Warner E. Fibrin fixation of skin transplants.Surgery 1944;15:90–95.
Cronkite E, Lozner E, Deaver J. Use of thrombin and fibrinogen in skin grafting.JAMA 1944;124:976–978.
Matras H. Fibrin seal: the state of the art.J Oral Maxillofac Surg 1985;43:605–611.
Siedentop K, Harris D, Sanchez B. Autologous fibrin tissue adhesive: factors influencing bonding power.Laryngoscope 1988;98:731–733.
Saltz R, Sierra D, Feldman D, et al. Experimental and clinical applications of fibrin glue.Plast Reconstr Surg 1991;88:1005–1015.
Wan H, Huang S, Floyd D, et al. Is the amount of fibrinogen in cryoprecipitate adequate for fibrin glue? Introducing an improved recycled cryoprecipitate method. Transfusion 1989;29(Suppl):41S.
Gibble J, Ness P. Fibrin glue: the perfect operative sealant?Transfusion 1990;30:741–747.
Toriumi D, O’Grady K. Surgical tissue adhesives in otolaryngology-head and neck surgery.Otolaryngol Clin North Am 1994;27:203–209.
Ishitani M, McGahren E, Sibley D, et al. Laparoscopically applied fibrin glue in experimental liver trauma.J Pediatr Surg 1989;24:867–871.
McCarthy P. Fibrin glue in cardiothoracic surgery.Transf Med Rev 1993;8:173–179.
Papatheofanis F, Barmada R. The principles and applications of surgical adhesives.Surg Ann 1993;25:49–81.
Shaffrey C, Spotnitz W, Shaffrey M, et al. Neurosurgical applications of fibrin glue: augmentation of dural closure in 134 patients.Neurosurgery 1990;26:207–210.
Errett L, Walsh G. Life salvage with fibrin glue in three cases of exsanguinating hemorrhage.Can J Surg 1986;29:214–216.
Dresdale A, Rose E, Jeevanandam V, et al. Preparation of fibrin glue from single–donor fresh-frozen plasma.Surgery 1985;97:750–755.
Blood collection storage and component preparation. In: Walker R, ed. Technical Manual 11th ed. Bethesda: American Association of Blood Banks, 1993;717–747.
Stemberger A, Blümel. Fibrinogen-fibrin conversion and inhibition of fibrinolysis.Thorac Cardiovasc Surg 1982;30:209–214.
Ciano P, Colvin R, Dvorak A, et al. Macrophage migration in fibrin gel matrices.Lab Invest 1986;54:62–70.
Houston K, Rotstein O. Fibrin sealant in high-risk colonic anastomoses.Arch Surg 1988;123:230–234.
Byrne D, Hardy J, Wood R, et al. Effect of fibrin glues on the mechanical properties of healing wounds.Br J Surg 1991;78:841–843.
Spotnitz W, Mintz P, Avery N, et al. Fibrin glue from stored human plasma.Am Surg 1987;53:460–462.
Weis-Fogh U. Fibrinogen prepared from small blood samples for autologous use in a tissue adhesive system.Eur Surg Res 1988;20:381–389.
Kjaergard H, Weis-Fogh U, S;ohrensen H, et al. A simple method of preparation of autologous fibrin glue by means of ethanol.Surg Gynecol Obstet 1992;175:72–73.
DePalma L, Criss V, Luban N. The preparation of fibrinogen concentrate for use as fibrin glue by four different methods.Transfusion 1993;33:717–720.
Harris D, Siedentop K, Ham K, et al. Autologous fibrin tissue adhesive biodegradation and systemic effects.Larynogoscope 1987;97:1141–1144.
Pipan C, Glasheen W, Matthew T, et al. Effects of antifibrinolytic agents on the life span of fibrin sealant.J Surg Res 1992;53:402–407.
Ismal S, Glasheen W, Gonias S, et al. Bovine fibrin sealant: the intraperitoneal life span of a new hemostatic agent.Am Coll Surg 1993;44:572–574.
Rousou J, Engelman R, Breyer R. Fibrin glue: an effective hemostatic agent for nonsuturable intraoperative bleeding.Ann Thorac Surg 1984;38:409–410.
Matthew T, Spotnitz W, Korn I, et al. Four years’ experience with fibrin sealant in thoracic and cardiovascular surgery.Ann Thorac Surg 1990;50:40–44.
Baker J, Spotnitz W, Nolan S. A technique for spray application of fibrin glue during cardiac operations.Ann Thorac Surg 1987;43:564–565.
Joyce D, McGrath L, Gonzalez-Lavin L. A method of applying fibrin sealant using an atomizing agent.Ann Thorac Surg 1989;47:320.
Redl H, Schlag G, Dinges H. Methods of fibrin seal application.Thorac Cardiovasc Surg 1982;30:223–227.
Borst H, Haverich A, Walterbusch G, et al. Fibrin adhesive: an important hemostatic adjunct in cardiovascular operations.Thorac Cardiovasc Surg 1982;84:548–553.
Lerner R, Binur N. Current research review. Current status of surgical adhesives.J Surg Res 1990;48:165–181.
Spotnitz W, Dalton S, Baker J, et al. Reduction of perioperative hemorrhage by anterior mediastinal spray application of fibrin glue during cardiac operations.Ann Thorac Surg 1987;44:529–531.
Gundry S, Behrendt D. A quantitative and qualitative comparison of fibrin glue, albumin, and blood as agents to pretreat porous vascular grafts.J Surg Res 1987;43:75–77.
Moront M, Katz N, O’Connell J, et al. The use of topical fibrin glue at cannulation sites in neonates.Surg Gynecol Obstet 358–359.
Di Lello F, Mullen D, Flemma R. Sutureless fixation of long aortocoronary saphenous vein grafts with oxidized regenerated cellulose.Ann Thorac Surg 1989;47:473–474.
Rousou J, Gonzalez-Lavin L, Cosgrove D, et al. Randomized clinical trial of fibrin sealant in patients undergoing resternotomy or reoperation after cardiac operations.J Thorac Cardiovasc Surg 1989;97:194–203.
Clark D, Drohan W, Miekka S, et al. Strategy for purification of coagulation factor concentrates.Ann Clin Lab Sci 1989;19:196–207.
Burnouf-Radosevich M, Burnouf T, Huart J. Biochemical and physical properties of a solvent-detergent-treated fibrin glue.Vox Sang 1990;58:77–84.
Lupinetti F, Stoney W, Alford W, et al. Cryoprecipitate-topical thrombin glue.J Thorac Cardiovasc Surg1985;90:502–505.
Kram H, Bansal M, Timberlake O, et al. Antibacterial effects of fibrin glue-antibiotic mixtures.J Surg Res 1991;50:175–178.
Bänninger H, Hardegger T, Tobler A, et al. Fibrin glue in surgery: frequent development of inhibitors of bovine thrombin and human factor V.Br J Haemost 1993;85:528–532.
Berruyer M, Amiral J, Ffrench P, et al. Immunization by bovine thrombin used with fibrin glue during cardiovascular operations.J Thorac Cardiovasc Surg 1993;105:892–897.
Milde L. An anaphylactic reaction to fibrin glue.Anesth Analg 1989;69:684–686.
Berguer R, Staerkel R, Moore E, et al. Warning: fatal reaction to the use of fibrin glue in deep hepatic wounds. Case reports.J Trauma 1991;31:408–411.
Barton B, Moore E, Pearce W. Fibrin glue as a biologic vascular patch—a comparative study.J Surg Res 1986;40:510–513.
Stark J, de Leval M. Experience with fibrin seal (Tisseel) in operations for congenital heart defects.Ann Thorac Surg 1984;38:411–413.
Ennker I, Ennker J, Schoon D, et al. Formaldehyde-free collagen glue in experimental lung gluing.Ann Thorac Surg 1994;57:1622–1627.
Vincent J, Skotnicki S, van der Meer J, et al. Resorbable suture support for ventricular aneurysmectomy.J Thorac Cardiovasc Surg 1987;94:430–433.
Feikes H, Daugharthy J, Perry J, et al. Preservation of all chordae tendineae and papillary muscle during mitral valve replacement with a tilting disc valve.J Cardiac Surg 1990;5:81–85.
Dilip K, Vachaspathy P, Clarke B, et al. Haemolysis following mitral valve repair.J Cardiovasc Surg 1992;33:568–569.
Shapira N. An alternative to felt pledgets in cardiac surgery.Ann Thorac Surg 1986;41:219–221.
Borst H. Dire consequences of the indiscriminate use of Teflon felt pledgets.J Thorac Cardiovasc Surg 1987;94:442–443.
Bojar R, Payne D, Sheffield A, et al. Successful repair of postoperative ascending aortic mycotic false aneurysms using circulatory arrest.Ann Thorac Surg 1988;46:182–186.
Barbalinardo R, Citrin P, Franco C, et al. A comparison of isobutyl 2-cyanoacrylate glue, fibrin adhesive, and oxidized regenerated cellulose for control of needle hole bleeding from polytetrafluoroethylene vascular prostheses.J Vase Surg 1986;4:220–223.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag New York, Inc.
About this chapter
Cite this chapter
Mair, D.C., Miller, J.P., Mintz, P.D. (1998). Fibrin Glue and Topical Hemostasis in Cardiac Surgery. In: Krieger, K.H., Isom, O.W. (eds) Blood Conservation in Cardiac Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2180-7_17
Download citation
DOI: https://doi.org/10.1007/978-1-4612-2180-7_17
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-94908-6
Online ISBN: 978-1-4612-2180-7
eBook Packages: Springer Book Archive