Abstract
Although hormonal regimens provide effective, reversible contraception for women, no effective hormonal contraceptive regimen has yet been developed for men. Testosterone decreases gonadotropin secretion by exerting negative feedback at both the hypothalamus and pituitary (1–3), thereby inhibiting spermatogenesis. Administration of exogenous T causes azoospermia in only 50–70% of men, however (4). Agonist analogs of GnRH can inhibit gonadotropin secretion and gonadal function (5), but they do not consistently induce azoospermia in primates when given alone or in combination with androgen (6–9).
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References
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Bremner, W.J., Bagatell, C.J., Steiner, R.A. (1992). Gonadotropin Releasing Hormone Antagonist Plus Testosterone: A Potential Male Contraceptive. In: Crowley, W.F., Conn, P.M. (eds) Modes of Action of GnRH and GnRH Analogs. Serono Symposia, USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2916-2_21
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DOI: https://doi.org/10.1007/978-1-4612-2916-2_21
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