Abstract
Neutrophils adhere to endothelium by neutrophil-dependent or endothelial-dependent mechanisms (1). The neutrophil-dependent mechanism operates when the neutrophil is directly stimulated by activating agents such as bacterial chemotactic peptides, complement fragments, or tumor necrosis factor/cachectin (TNF). Neutrophil-dependent adherence is mediated by the interaction of neutrophil CD11b/CD18 (Mac-1, Mol) and endothelial intercellular adhesion molecule-1 (ICAM-1) (2).
This work was supported by MRC of Canada 4219 and USPHS HL 30542. Dr. Doerschuk is the recipient of an American Lung Association Fellowship and an Edward Livingston Trudeau Scholar Award. Dr. Harlan is an Established Investigator of the American Heart Association.
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Doerschuk, C.M., Winn, R.K., Harlan, J.M. (1990). Mechanisms of Neutrophil Emigration. In: Springer, T.A., Anderson, D.C., Rothlein, R., Rosenthal, A.S. (eds) Leukocyte Adhesion Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3234-6_6
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DOI: https://doi.org/10.1007/978-1-4612-3234-6_6
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