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Adenosine Receptors Mediating Inhibition of Peripheral and Central Neurons

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Purines in Cellular Signaling

Abstract

The inhibition caused by adenosine on neurotransmitter release from rat phrenic nerve terminals, described by Ginsborg and Hirst (1972), constitutes the first of a series of observations demonstrating that adenosine decreases the release of excitatory neurotransmitters (acetylcholine, serotonin, noradrenaline, glutamate, aspartate) (see e.g. Ribeiro and SebastiĆ£o, 1989). No consistent descriptions appeared on reduction by adenosine of the release of inhibitory neurotransmitters such as GABA or glycine.

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Ribeiro, J.A., Sebastiao, A.M. (1990). Adenosine Receptors Mediating Inhibition of Peripheral and Central Neurons. In: Jacobson, K.A., Daly, J.W., Manganiello, V. (eds) Purines in Cellular Signaling. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3400-5_26

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  • DOI: https://doi.org/10.1007/978-1-4612-3400-5_26

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7996-9

  • Online ISBN: 978-1-4612-3400-5

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