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Mucosal Immunity in the Gastrointestinal Tract in Relation to ETEC Vaccine Development

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Progress in Vaccinology

Part of the book series: Progress in Vaccinology ((VACCINOLOGY,volume 2))

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Abstract

Enteric infection with enterotoxinogenic Escherichia coli (ETEC) is one of the most important causes of diarrhea in developing countries and is also the most frequent cause of diarrhea among travelers. Illness resulting from ETEC infection is characterized by watery diarrhea, often accompanied by low grade fever, abdominal cramps, malaise, and vomiting. In its most severe form ETEC infection may result in cholera-like disease leading to severe dehydration and sometimes death.

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References

  1. Åhrén C, Svennerholm A-M: Synergistic protective effect of antibodies against Escherichia coli enterotoxin and colonization factor antigens. Infect Immun 1982; 38: 74–79.

    PubMed  Google Scholar 

  2. Åhrén C, Svennerholm A-M: Experimental enterotoxin-induced Escherichia coli diarrhea and protection induced by previous infection with bacteria of the same adhesin or enterotoxin type. Infect Immun 1985; 50: 225–261.

    Google Scholar 

  3. Åhrén C, Gothefors L, Stoll B, et al: Comparison of methods for detection of colonization factor antigens (CFAs) on enterotoxigenic Escherichiacoli. J Clin Microbiol 1986; 23: 586–591.

    PubMed  Google Scholar 

  4. Black RE: The epidemiology of cholera and enterotoxigenic E. coli diarrheal disease, in Holmgren J, Lindberg A, Möllby R (eds): Development of Vaccines and Drugs Against Diarrhea. 11th Nobel Conference, Stockholm. Lund, Studentlitteratur, 1986, pp 23–32.

    Google Scholar 

  5. Burgess MN, Bywater RJ, Cowley CM, et al: Biological evaluation of a methanol-soluble, heat-stable Escherichia coli enterotoxin in infant mice, pigs, rabbits and calves. Infect Immun 1978; 21: 526–531.

    PubMed  CAS  Google Scholar 

  6. Cravioto A, Scotland SM, Rowe B: Hemagglutination activity and colonization factor antigens I and II in enterotoxigenic and nonenterotoxigenic strains of Escherichia coli isolated from humans. Infect Immun 1982; 36: 189–197.

    PubMed  CAS  Google Scholar 

  7. Duguid JP, Smith IW, Dempster G, Edmunds PN: Nonflagellar filamentous appendages (“fimbriae”) and haemagglutinating activity in Bacteriumcoli. J Pathol Bacteriol 1955; 70: 335–348.

    Article  PubMed  CAS  Google Scholar 

  8. Evans DG, Silver RP, Evans DJ Jr, et al: Plasmid-controlled colonization factor associated with virulence in Escherichia coli enterotoxigenic for humans. Infect Immun 1975; 12: 656–667.

    PubMed  CAS  Google Scholar 

  9. Evans DG, Evans DJ Jr: New surface-associated heat-labile colonization factor antigen (CFA/II) produced by enterotoxigenic Escherichia coli of ser- ogroups 06 and 08. Infect Immun 1978; 21: 638–647.

    PubMed  CAS  Google Scholar 

  10. Evans DG, Evans DJ Jr, Tjoa WS, DuPont HL: Detection and characteri zation of colonization factor of enterotoxigenic Escherichia coli isolated from adults with diarrhea. Infect Immun 1978; 19: 727–736.

    PubMed  CAS  Google Scholar 

  11. Evans DG, Graham DY, Evans DJ Jr, Opekun A: Administration of purified colonization factor antigens (CFA/I, CFA/II) of enterotoxigenic Escherichia coli to volunteers: response to challenge with virulent enterotoxigenic Escherichia coli. Gastroenterology 1984; 87: 934–940.

    PubMed  CAS  Google Scholar 

  12. Frantz JC, Robertson DC: Immunological properties of Escherichia coli heat- stable enterotoxins: development of a radioimmunoassay specific for heat- stable enterotoxins with suckling mouse activity. Infect Immun 1981; 33: 193–198.

    PubMed  CAS  Google Scholar 

  13. Gothefors L, Åhrén C, Stoll B, et al: Presence of colonization factor antigens on fresh isolates of fecal Escherichia coli: a prospective study. J Infect Dis 1985; 152: 1128–1133.

    Article  PubMed  CAS  Google Scholar 

  14. Hirst TR, Sanchez J, Kaper JB, et al: Mechanism of toxin secretion by Vibrio cholerae investigated in strains harboring plasmids that encode heat-labile enterotoxins of Escherichia coli. Proc Natl Acad Sei USA 1984; 81: 7752–7756.

    Article  CAS  Google Scholar 

  15. Holmgren J, Fredman P, Lindblad M, et al: Rabbit intestinal glycoprotein receptor for Escherichia coli heat-labile enterotoxin lacking affinity for cholera toxin. Infect Immun 1982; 38: 424–433.

    PubMed  CAS  Google Scholar 

  16. Holmgren J: Toxins affecting intestinal transport processes, in Sussman M (ed): The Virulence of Escherichia coli. London, Academic Press, 1985, pp 177–191.

    Google Scholar 

  17. Holmgren J, Lycke N: Immune mechanisms in enteric infections, in Holmgren J, Lindberg A, Möllby R (eds): Development of Vaccines and Drugs Against Diarrhea. 11th Nobel Conference, Stockholm. Lund, Studentlitteratur, 1986, pp 9–22.

    Google Scholar 

  18. Jertborn M, Svennerholm A-M, Holmgren J: Five-year immunological memory after oral cholera vaccination. J Infect Dis 1988; 157: 374–377.

    Article  PubMed  CAS  Google Scholar 

  19. Kawanishi H, Strober W: T cell regulation of IgA immunoglobulin production in gut-associated lymphoid tissues. Mol Immunol 1983; 20: 917–930.

    Article  PubMed  CAS  Google Scholar 

  20. Klipstein FA, Engert RF, Clements JD, Houghton RA: Protection against human and porcine enterotoxinogenic Escherichia coli in rats immunized with a cross-linked toxoid vaccine. Infect Immun 1983; 40: 924–929.

    PubMed  CAS  Google Scholar 

  21. Lange S, Nygren H, Svennerholm A-M, Holmgren J: Antitoxic cholera immunity in mice: influence of antigen deposition on antitoxin-containing cells and protective immunity in different parts of the intestine. Infect Immun 1980; 28: 17–23.

    PubMed  CAS  Google Scholar 

  22. Levine MM: Immunity to cholera as evaluated in volunteers, in Ouchterlony Ö, Holmgren J (eds): Cholera and Related Diarrheas. 43rd Nobel Symposium, Stockholm. Basel, Karger, 1980, pp 195–203.

    Google Scholar 

  23. Levine M, Morris JG, Losonsky G, et al: Fimbrial (Pili) Adhesins as Vaccines: Protein-Carbohydrate Interactions in Biological Systems. FEMS Symposium No. 31. London, Academic Press, 1986, pp 143–145.

    Google Scholar 

  24. Lopez-Vidal Y, Åhrén C, Svennerholm A-M: Colonization diarrhoea and protective immunogenicity of a CFA-deficient enterotoxin-producing Escherichia coli mutant in a non-ligated intestine experimental model. Acta Pathol Microbiol Scand Sect. B. 1987; 95: 123–130.

    CAS  Google Scholar 

  25. Lycke N, Holmgren J: Intestinal mucosal memory and presence of memory cells in lamina propria and Peyer’s patches in mice 2 years after oral immunization with cholera toxin. Scand J Immunol 1986; 23: 611–616.

    Article  PubMed  CAS  Google Scholar 

  26. Morgan DR, Dupont HL, Wood LD, Kohl S: Cytotoxicity of leukocytes from normal and Shigella-susceptible (opium-treated) guinea pigs against virulent Shigella sonnei. Infect Immun 1984; 46: 22–24.

    PubMed  CAS  Google Scholar 

  27. Nencioni L, Villa D, Boraschi D, et al: Natural and antibody-dependent cell- mediated activity against Salmonella typhimurium by peripheral and intestinal lymphoid cells in mice. J Immunol 1983; 130: 903–907.

    PubMed  CAS  Google Scholar 

  28. Pierce NF, Cray WC Jr: Determinants of the localization, magnitude and duration of a specific mucosal IgA plasma cell response in enterically immunized rats. J Immunol 1982; 128: 1311–1315.

    PubMed  CAS  Google Scholar 

  29. Rao MC: Toxins which activate guanylate cyclase: heat-stable enterotoxins, in Microbial Toxins and Diarrheal Disease. Ciba Foundation Symposium 112. London, Pitman, 1985, pp 74–93.

    Google Scholar 

  30. Sack R: Enterotoxigenic Escherichia coli: identification and characterization. J Infect Dis 1980; 142: 279–286.

    Article  PubMed  CAS  Google Scholar 

  31. Sanchez J, Uhlin B-E, Grundström T, et al: Immunoactive chimeric ST-LT enterotoxins of Escherichia coli generated by in vitro gene fusion. FEBS Lett 1986; 208: 194–198.

    Article  PubMed  CAS  Google Scholar 

  32. Smyth CJ: Two mannose-resistant haemagglutinins on enterotoxigenic Escherichia coli of serotype 06:K15:H16 or H- isolated from travellers’ and infantile diarrhoea. J Gen Microbiol 1982; 128: 2081–2096.

    PubMed  CAS  Google Scholar 

  33. Stoll BJ, Svennerholm A-M, Gothefors L, et al: Local and systemic antibody responses to naturally acquired enterotoxinogenic Escherichia coli diarrhea in an endemic area. J Infect Dis 1986; 153: 527–534.

    Article  PubMed  CAS  Google Scholar 

  34. Svennerholm A-M, Lange S, Holmgren J: Correlation between intestinal synthesis of specific immunoglobulin A and protection against experimental cholera in mice. Infect Immunol 1978: 21: 1–6.

    CAS  Google Scholar 

  35. Svennerholm A-M, Åhrén C: Immune protection against enterotoxigenic E. coli: search for synergy between antibodies to enterotoxin and somatic antigens. Acta Pathol Microbiol Immunol Scand [C] 1982; 90: 1–6.

    CAS  Google Scholar 

  36. Svennerholm A-M, Gothefors L, Sack DA, et al: Local and systemic antibody responses and immunological memory in humans after immunization with cholera B subunit by different routes. Bull WHO 1985; 62: 909–918.

    Google Scholar 

  37. Svennerholm A-M, Wikström M, Lindblad M, Holmgren J: Monoclonal antibodies against Escherichia coli heat-stable toxin (STa) and their use in a diagnostic ST ganglioside GM, enzyme-linked immunosorbent assay. J Clin Microbiol 1986; 24: 585–590.

    PubMed  CAS  Google Scholar 

  38. Svennerholm A-M, Wikström M, Lindblad M, Holmgren J: Monoclonal antibodies to Escherichia coli heat-labile enterotoxins: neutralizing activity and differentiation of human and porcine LTs and cholera toxin. Med Biol 1986; 64: 23–30.

    PubMed  CAS  Google Scholar 

  39. Svennerholm A-M, Lopez-Vidal Y, Holmgren J, et al: Role of PCF8775 antigen and its coli surface subcomponents for colonization, disease and protective immunogenicity of enterotoxigenic Escherichia coli in rabbits. Infect Immun 1988; 56: 523–528.

    PubMed  CAS  Google Scholar 

  40. Svennerholm A-M, Lopez-Vidal Y, Holmgren J, et al: Role of PCF8775 antigen and its coli surface subcomponents for colonization, disease and protective immunogenicity of enterotoxigenic Escherichia coli in rabbits. Infect Immun 1988; 56: 523–528.

    PubMed  CAS  Google Scholar 

  41. Tayot J-L, Holmgren J, Svennerholm L, et al: Receptor-specific large scale purification of cholera toxin on silica beads derivatized with lyso-GM,-ganglioside. Eur J Biochem 1981; 113: 249–258.

    Article  PubMed  CAS  Google Scholar 

  42. Thomas LV, Cravioto A, Scotland SM, Rowe B: New fimbrial antigenic type (E8775) that may represent a colonization factor in enterotoxigenic Escherichia coli in humans. Infect Immun 1982; 35: 1119–1124.

    PubMed  CAS  Google Scholar 

  43. Thomas LV, Rowe B: The occurrence of colonization factors (CFA/I, CFA/ II and E8775) in enterotoxigenic Escherichia coli from various countries in South East Asia. Med Microbiol Immunol 1982; 171: 85–90.

    Article  PubMed  CAS  Google Scholar 

  44. Thomas LV, McConnell MM, Rowe B, Field AM: The possession of three novel coli surface antigens by enterotoxigenic Escherichia coli strains positive for the putative colonization factor PCF8775. J Gen Microbiol 1985; 131: 2317–2326.

    Google Scholar 

  45. To SC-M, Moon HW, Runnels PL: Type 1 pili (Fl) of porcine enterotoxigenic Escherichia coli: vaccine trial and tests for production in the small intestine during disease. Infect Immun 1984; 43: 1–5.

    PubMed  CAS  Google Scholar 

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© 1989 Springer-Verlag New York Inc.

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Svennerholm, AM., Holmgren, J., Lopez-Vidal, Y., Sanchez, J., Åhrén, C. (1989). Mucosal Immunity in the Gastrointestinal Tract in Relation to ETEC Vaccine Development. In: Talwar, G.P. (eds) Progress in Vaccinology. Progress in Vaccinology, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3508-8_18

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  • DOI: https://doi.org/10.1007/978-1-4612-3508-8_18

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-96734-9

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