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Role of macrophages and cytokines in B-cell death

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Lessons from Animal Diabetes VI

Part of the book series: Rev.Ser.Advs.Research Diab.Animals (Birkhäuser) ((RSARDA,volume 6))

Abstract

In recent years data have accumulated suggesting an important contribution of macrophages in the pathogenesis of IDDM, participating as primary inductor cells of autoimmunity, or as effector cells of B-cell destruction. In the spontaneously diabetic NOD mouse, macrophages and dendritic cells are the first cells infiltrating at perivascular and peri-insular regions in early insulitis beginning at the age of 3 wk.1,2 These cells start to invade the inner islet tissue at 30 days of age.3 Comparable features were found earlier in prediabetic insulitis of BB rats, with macrophage infiltration preceding and being essential for later invasion of T-lym-phocytes.4 The relevance of macrophages for the initiation of the disease could be shown by prevention of insulitis and diabetes development after modulation of macrophages in vivo by silica administration in both animal models4–7 or by interference with macrophage adhesion receptors.8 The prevention of islet infiltration in NOD mice by silica treatment was dependent on the young age of the recipient.9 These studies indicate the involvement of macrophages in initial steps of the pathogenesis in animal models. Although silica specifically targets macrophages, this does not lead to their elimination. Rather, redirection of monocyte homing to sites of inflammation, silica deposits, and functional impairment of macrophages are seen.

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Author information

Authors and Affiliations

  1. Diabetes Research Institute, Heinrich-Heine-University of Dusseldorf, D-40225, Dusseldorf, Germany

    Antje Faust, Rainer Kleemann, Helga Rothe & Hubert Kolb

  2. Diabetes Research Institute, Auf’m Hennekamp 65, D-40225, Düsseldorf, Germany

    Hubert Kolb

Authors
  1. Antje Faust
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  2. Rainer Kleemann
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  3. Helga Rothe
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  4. Hubert Kolb
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Editors and Affiliations

  1. Department of Biochemistry, Hadassah Medical Center, POB 12000, IL 91120, Jerusalem, Israel

    Eleazar Shafrir

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© 1996 Birkhäuser Boston

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Faust, A., Kleemann, R., Rothe, H., Kolb, H. (1996). Role of macrophages and cytokines in B-cell death. In: Shafrir, E. (eds) Lessons from Animal Diabetes VI. Rev.Ser.Advs.Research Diab.Animals (Birkhäuser), vol 6. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4112-6_3

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  • DOI: https://doi.org/10.1007/978-1-4612-4112-6_3

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4612-8658-5

  • Online ISBN: 978-1-4612-4112-6

  • eBook Packages: Springer Book Archive

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