Skip to main content
SpringerLink
Log in

Specific Action of Ethanol on Lateral and Vertical Membrane Lipid Domains

  • Chapter
Molecular Mechanisms of Alcohol

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 21))

Abstract

Chin and Goldstein (10) in 1977 published a study on the biophysical effects of ethanol in membranes from ethanol-tolerant and control animals. Their work showed that ethanol in vitro fluidizied membranes and that chronic ethanol consumption resulted in a structural change in the membrane that made the membrane resistant to in vitro fluidization by ethanol. That study and subsequent studies resulted in the development of a hypothesis that proposes that membrane fluidity is involved in the actions of ethanol and has been used to explain ethanol effects ranging from sensitivity and intoxication to membrane transport and neurotransmitter uptake and release (for a review see 24).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aloia, R.C., Curtain, C.C., and Gordon, L.M. (Eds.) (1988) in Advances in Membrane Fluidity, Vol 2, Alan R. Liss, New York.

    Google Scholar 

  2. Antonian, L, Shinitzky, M., Samuel, D., and Lippa, A.S. (1987) Neurosci. Biobehav. Rev. 11, 399–413.

    Article  PubMed  CAS  Google Scholar 

  3. Armbrecht, H.J., Wood, W.G., Wise, R.W., Walsh, J.B., Thomas, B.N., and Strong, R. (1983) J. Pharmacol. Exp. Ther. 226, 387–391.

    PubMed  CAS  Google Scholar 

  4. Ballou, LR., DeWitt, L.M., and Cheung, W.Y. (1986) J. Biol. Chem. 261, 3107–3111.

    PubMed  CAS  Google Scholar 

  5. Beauge, F., Stibler, H., and Borg, S. (1987) Alcoholism: Clin. Exp. Res. 11, 322–326.

    Google Scholar 

  6. Bretscher, M.S. (1972) Nature 236, 11–12.

    Article  CAS  Google Scholar 

  7. Chabanel, A., Abbott, R.E., Chien, S., and Schachter, D. (1985) Biochim. Biophys. Acta 816, 142–152.

    Article  PubMed  CAS  Google Scholar 

  8. Chandra, R., Joshi, P.C., Bajpai, V.K., and Gupta, CM. (1987) Biochim. Biophys. Acta 902, 253–262.

    Article  PubMed  CAS  Google Scholar 

  9. Chapman, D. and Hayward, J.A. (1985) Biochem. J. 228, 281–295.

    PubMed  CAS  Google Scholar 

  10. Chin, J.H. and Goldstein, D.B. (1977) Science 196, 684–685.

    Article  PubMed  CAS  Google Scholar 

  11. Chiu, D., Lubin, B., and Shohet, S.B. (1979) Br. J. Haematol. 41, 223–234.

    Article  PubMed  CAS  Google Scholar 

  12. Cogan, U. and Schachter, D. (1981) Biochemistry 20, 6396–6403.

    Article  PubMed  CAS  Google Scholar 

  13. Crews, F.T., Majchrowicz, E., and Meeks, R. (1983) Psychopharmacology 81, 208–213.

    Article  PubMed  CAS  Google Scholar 

  14. Datta, D.B. (1987) A Comprehensive Introduction to Membrane Biochemistry, Floral Publishing, Madison, Wisconsin.

    Google Scholar 

  15. Devaux, P.F. (1988) FEBS Lett. 234, 8–12.

    Article  PubMed  CAS  Google Scholar 

  16. Ellingson, J.S., Taraschi, T.F., Wu, A., Zimmerman, R., and Rubin, E. (1988) Proc. Natl. Acad. Sci. USA 85, 3353–3357.

    Article  PubMed  CAS  Google Scholar 

  17. Fisher, G.J., Freter, C.E., Ladenson, R.C, and Silbert, D.F. (1983) J. Biol. Chem. 258, 11705–11712.

    PubMed  CAS  Google Scholar 

  18. Franks, N.P. and Lieb, W.R. (1986) Proc. Natl. Acad. Sci. USA 83, 5116–5120.

    Article  PubMed  CAS  Google Scholar 

  19. Franks, N.P. and Lieb, W.R. (1987) Alcohol Alcoholism (Suppl) 1, 139–145.

    CAS  Google Scholar 

  20. Gastaldi, M., Lerique, B., Feugere, T., Le Petit-Thevenin, J., Nobill, O., and Boyer, J. (1988) Alcoholism: Clin. Exp. Res. 12, 356–359.

    Article  CAS  Google Scholar 

  21. Gonzales, R.A., Ganz, N., and Crews, F.T. (1987) J. Neuro-chem. 49, 158–162.

    CAS  Google Scholar 

  22. Gorka, C, Sun, G.Y., Sun, A.Y., Schroeder, F., and Wood, W.G. (1989) Alcoholism: Clin. Exp. Res. in press.

    Google Scholar 

  23. Harris, R.A., Baxter, D.M., Mitchell, M.A., and Hitzemann, R.J. (1984) Mol.Pharmacol. 25, 401–409.

    PubMed  CAS  Google Scholar 

  24. Hunt, W.A. (1985) Alcohol and Biological Membranes. Guilford Press, New York.

    Google Scholar 

  25. Jain, S.K. (1985) J. Clin. Invest. 76, 281–286.

    Article  PubMed  CAS  Google Scholar 

  26. Kannagi, R., Koizumi, K., and Masuda, T. (1981) J. Biol. Chem. 256, 1177–1184.

    PubMed  CAS  Google Scholar 

  27. Kuypers, F.A., Abraham, S., Lubin, B., and Chiu, D. (1988) J. Lab. Clin. Med. 111, 529–536.

    PubMed  CAS  Google Scholar 

  28. Lubin, B., Chiu, D., Bastacky, B., Roelofson, B., and van Deenen, L.L.M. (1981) J. Clin. Invest. 67, 1643–1649.

    Article  PubMed  CAS  Google Scholar 

  29. Lyte, M. and Shinitzky, M. (1985) Biochim. Biophys. Acta 812, 133–138.

    Article  PubMed  CAS  Google Scholar 

  30. Momchilova, A, Petkova, D., and Koumanov, K. (1986) Int. J. Biochem. 18, 659–663.

    Article  PubMed  CAS  Google Scholar 

  31. Morrot, G., Cribler, S., Devaux, P.F., Geldwerth, D., Davoust, J., Bureau, J.F., Fellmann, P., Herve, P., and Frilley, B. (1986) Proc. Natl. Acad. Sci. USA 83, 6863–6867.

    Article  PubMed  CAS  Google Scholar 

  32. Rottenberg, H., Waring, A., and Rubin, E. (1981) Science 213, 583–585.

    Article  PubMed  CAS  Google Scholar 

  33. Rowe, E.S. (1987) Biochim. Biophys. Acta 813, 321–330.

    Google Scholar 

  34. Schachter, D., Abbott, R.E., Cogan, U., and Flamm, M. (1983) Ann. N.Y. Acad. Sci. 414, 19–28.

    Article  PubMed  CAS  Google Scholar 

  35. Schachter, D., Cogan, U., and Abbott, R.E. (1982) Biochemistry 21, 2146–2150.

    Article  PubMed  CAS  Google Scholar 

  36. Schroeder, F., Morrison, W.J., Gorka, C, and Wood, W.G. (1988) Biochim. Biophys. Acta 946, 85–94.

    Article  PubMed  CAS  Google Scholar 

  37. Schroeder, F., Wood, W.G., Morrison, W.J., Fontaine, R.N., and Kier, A.B. (1989) in Neurochemical Aspects of Phospholipid Metabolism, (Horrocks, L., ed.) Raven Press, New York, in press.

    Google Scholar 

  38. Seigneuret, M., Zachowski, A., Hermann, A., and Devaux, P.P. (1984) Biochemistry 23, 4271–4275.

    Article  PubMed  CAS  Google Scholar 

  39. Sheetz, M.P. and Singer, S.J. (1974) Proc. Natl. Acad. Sci. USA 71, 4457–4461.

    Article  PubMed  CAS  Google Scholar 

  40. Shukla, S.D. and Hanahan, D.J. (1982) J. Biol. Chem. 257, 2908–2911.

    PubMed  CAS  Google Scholar 

  41. Strong, R. and Wood, W.G. (1984) J. Pharmacol. Exp. Ther. 229, 726–730.

    PubMed  CAS  Google Scholar 

  42. Stubbs, C.D., Williams, B.W., Pryor, C.L., and Rubin, E. (1988) Arch. Biochem. Biophys. 262, 560–573.

    Article  PubMed  CAS  Google Scholar 

  43. Sun, G. Y., Huang, H-M., Lee, D-Z., and Sun, A. Y. (1984) Life Sci. 35, 2127–2133.

    Article  PubMed  CAS  Google Scholar 

  44. Sun, G.Y. and Sun, A.Y. (1983) Biochem. Biophys. Res. Commun. 113, 262–268.

    Article  PubMed  CAS  Google Scholar 

  45. Sun, G.Y. and Sun, A.Y. (1985) Alcoholism: Clin. Exp. Res. 9, 164–180.

    Article  CAS  Google Scholar 

  46. Sweet, W.D. and Schroeder, F. (1986) Biochem. J. 239, 301–310.

    PubMed  CAS  Google Scholar 

  47. Sweet, W.D. and Schroeder, F. (1988) in Advances in Membrane Fluidity, Vol 2 (Aloia, R.C., Curtain, C.C., and Gordon, L.M., eds.), Alan Ft. Liss, New York, pp. 17–42.

    Google Scholar 

  48. Sweet, W.D., Wood, W.G., and Schroeder, F. (1987) Biochemistry 26, 2828–2835.

    Article  PubMed  CAS  Google Scholar 

  49. Tamura, A., Moriwaki, N., and Fujii, T. (1983) Chem. Pharm. Bull. 31, 1692–1697.

    PubMed  CAS  Google Scholar 

  50. Tanaka, K.-I. and Ohnishi, S.I. (1976) Biochim. Biophys. Acta 426, 218–231.

    Article  PubMed  CAS  Google Scholar 

  51. Taraschi, T.F., Ellingson, J.S., Wu, A., Zimmerman, R., and Rubin, E. (1986) Proc. Natl. Acad. Sci. USA 83, 9398–9402.

    Article  PubMed  CAS  Google Scholar 

  52. Treistman, S.N., Moynihan, M.M, and Wolf, D.E. (1987) Biochim. Biophys. Acta 898, 109–120.

    Article  PubMed  CAS  Google Scholar 

  53. Treistman, S.N. and Wilson, A. (1987) Proc. Natl. Acad. Sci. USA 84, 9299–9303.

    Article  PubMed  CAS  Google Scholar 

  54. Valverius, P., Hoffman, P.L., and Tabakoff, B. (1987) Mol. Pharmacol. 32, 217–222.

    PubMed  CAS  Google Scholar 

  55. Wood, W.G., Gorka, C, Armbrecht, H.J., Williamson, L.S., and Strong, R. (1986) Life Sci. 39, 2089–2095.

    Article  PubMed  CAS  Google Scholar 

  56. Wood, W.G., Gorka, C, Mendenhall, C.L., and Schroeder, F. (1989) Alcoholism: Clin. Exp. Res. in press.

    Google Scholar 

  57. Wood, W.G., Gorka, C, and Schroeder, F. (1989) J. Neurochem. in press.

    Google Scholar 

  58. Wood, W.G., Lahiri, S., Gorka, C, Armbrecht, H.J., and Strong, R. (1987) Alcoholism: Clin. Exp. Res. 11, 332–335.

    Article  CAS  Google Scholar 

  59. Wood, W.G. and Schroeder, F. (1988) Life Sci. 43, 467–475.

    Article  PubMed  CAS  Google Scholar 

  60. Zs.-Nagy, I. and Semsei, I. (1984) Exp. Gerontol. 19, 171–179.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Geriatric Research, Education and Clinical Center, VA Medical Center and Department of Pharmacology, University of Minnesota School of Medicine, Minneapolis, MN, USA

    W. G. Wood & A. M. Rao

  2. VA Medical Center, St. Louis, MO, USA

    C. Gorka

  3. Colleges of Pharmacy & Medicine, University of Cincinnati Medical Center, Cincinnati, OH, USA

    F. Schroeder

Authors
  1. W. G. Wood
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Gorka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. M. Rao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. F. Schroeder
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Sinclair Research Farm, University of Missouri, Columbia, MO, USA

    Grace Y. Sun  & Albert Y. Sun  & 

  2. Department of Anatomy and Neurobiology, University of Missouri, Columbia, MO, USA

    P. Kevin Rudeen

  3. VA Medical Center and Department of Pharmacology, University of Minnesota School of Medicine, Minneapolis, MN, USA

    W. Gibson Wood

  4. Department of Biochemistry, National Yang-Ming Medical College, Taipei, Taiwan, ROC

    Yau-Huei Wei

Rights and permissions

Reprints and permissions

Copyright information

© 1989 The Humana Press Inc.

About this chapter

Cite this chapter

Wood, W.G., Gorka, C., Rao, A.M., Schroeder, F. (1989). Specific Action of Ethanol on Lateral and Vertical Membrane Lipid Domains. In: Sun, G.Y., Rudeen, P.K., Wood, W.G., Wei, YH., Sun, A.Y. (eds) Molecular Mechanisms of Alcohol. Experimental Biology and Medicine, vol 21. Humana Press. https://doi.org/10.1007/978-1-4612-4514-8_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-4514-8_1

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8855-8

  • Online ISBN: 978-1-4612-4514-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation