Abstract
The 38–13 monoclonal antibody (1) detects a Burkitt’s lymphoma (BL)-associated glycolipidic antigen, BLA (2,3) which is present invariably on fresh Burkitt cells and retained in the majority of BL lines (4–6). This suggests that BL might derive from a cell at a defined stage of the B lineage differentiation. Initially (1), we did not detect any normal lymphocyte expressing BLA, whether originating from blood, lymph nodes, spleen or bone-marrow, or whether activated by mitogens. Because of the strong association of endemic BL with EBV which has been shown to replicate in the oro-pharynx (7), we searched for BLA positive cells in normal tonsils.
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Lipinski, M., Tétaud, C., Talbot, M., Wiels, J., Caillou, B., Tursz, T. (1987). Detection in Normal Tonsils of a Novel B Lymphocyte Population with a Burkitt-Like Phenotype. In: Levine, P.H., Ablashi, D.V., Nonoyama, M., Pearson, G.R., Glaser, R. (eds) Epstein-Barr Virus and Human Disease. Experimental Biology and Medicine, vol 15. Humana Press. https://doi.org/10.1007/978-1-4612-4590-2_26
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DOI: https://doi.org/10.1007/978-1-4612-4590-2_26
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