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Structure—Activity Relationships for alpha-2 Adrenergic Receptor Agonists and Antagonists

  • Chapter
The alpha-2 Adrenergic Receptors

Part of the book series: The Receptors ((REC))

Abstract

This chapter extends the discussion provided in Chapter 1 by providing an overview of the development of criteria for subclassification of alpha-adrenergic receptors into alpha-1 vs alpha-2 adrenergic receptor sybtypes and of more recent data suggesting the existence of subtypes of alpha-2 adrenergic receptors. A compendium of structure—activity data is then provided that ultimately permits a description of the structural requirements for the ligand-binding site of an alpha-2 adrenergic receptor.

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Authors
  1. Robert R. Ruffolo Jr.
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  2. Robert M. DeMarinis
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  3. Margaret Wise
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  4. J. Paul Hieble
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  1. Vanderbilt University, Nashville, Tennessee, USA

    Lee E. Limbird

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Ruffolo, R.R., DeMarinis, R.M., Wise, M., Hieble, J.P. (1988). Structure—Activity Relationships for alpha-2 Adrenergic Receptor Agonists and Antagonists. In: Limbird, L.E. (eds) The alpha-2 Adrenergic Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-4612-4596-4_4

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