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A Hypothesis Linking the Biochemical and Electrophysiological Sequelae of alpha-2 Adrenergic Receptor Occupancy with the Diverse Receptor-Mediated Physiological Effects

  • Chapter
The alpha-2 Adrenergic Receptors

Part of the book series: The Receptors ((REC))

Abstract

The original intent of this chapter was to summarize the contents of the preceding chapters in this volume on alpha-2 adrenergic receptors and provide a prospectus for future studies. The thorough content of each of the chapters, however, makes a summary per se redundant. Instead, we wondered how we could make these chapters ”talk to” each other, since they deal with topics as diverse as receptor heterogeneity (Chapter 1) and structure (Chapter 2), mechanisms for coupling with components of the adenylate cyclase system (Chapter 3), and multiple expressions of physiological effects in normal (Chapter 4) and in altered (Chapter 5) physiological states. We decided to review briefly the biochemical and electrophysiological consequences of alpha-2 adrenergic receptor occupancy as a foundation for an hypothesis that integrates changes measured by the biochemist (Δcyclic AMP, Δ[Ca2+], and ΔpHi) with those measured by the electro-physiologist (ΔCa2+ and K+ conductances) and those measured by the cellular physiologist (stimulation or inhibition of secretion).

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Authors
  1. Lori L. Isom
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  2. Lee E. Limbird
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Editors and Affiliations

  1. Vanderbilt University, Nashville, Tennessee, USA

    Lee E. Limbird

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© 1988 The Humana Press Inc.

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Isom, L.L., Limbird, L.E. (1988). What Happens Next?. In: Limbird, L.E. (eds) The alpha-2 Adrenergic Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-4612-4596-4_7

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  • DOI: https://doi.org/10.1007/978-1-4612-4596-4_7

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