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Interferon-induced Disease

  • Chapter
Concepts in Viral Pathogenesis II

Abstract

Interferons constitute a group of closely related cellular proteins that exhibit potent antiviral activity. There is abundant experimental data indicating that the production of interferons in the course of viral infections is an integral part of the host response, and interferon treatment of animals and humans is associated with prophylactic and therapeutic antiviral effects. Although interferon was originally considered to inhibit viral multiplication within the cell without affecting host cell metabolism or function, it is now widely accepted that interferons can also affect cell division and function both in cell culture and in the animal [1]. If this is so, we might expect to find instances in which too much interferon, instead of being beneficial, might even prove inimical to the host. I will summarize here the results of experiments which show that interferon can induce disease in mice and rats, and then try to discuss the relevance of these findings to our understanding of the pathogenesis of some viral diseases.

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Authors
  1. Ion Gresser
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Editor information

Editors and Affiliations

  1. Laboratory of Oral Medicine, National Institute of Dental Research, NIH, Bethesda, Maryland, 20892, USA

    Abner Louis Notkins M.D.

  2. Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, California, 92037, USA

    Michael B. A. Oldstone M.D.

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© 1986 Springer Science+Business Media New York

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Gresser, I. (1986). Interferon-induced Disease. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis II. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4958-0_27

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  • DOI: https://doi.org/10.1007/978-1-4612-4958-0_27

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9375-0

  • Online ISBN: 978-1-4612-4958-0

  • eBook Packages: Springer Book Archive

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