Abstract
The antigen receptor of T lymphocytes was recently identified as a complex consisting of a 90 KD disulfide linked heterodimer, termed Ti which is functionally and structurally associated with three additional molecular components, termed T3 (1). Whereas the former contains clonally unique epitopes and displays peptide variability among T cell clones of distinct specificities, no variability could be detected within any of the known three subunits of T3 (2,3). Monoclonal antibodies to T3 and Ti, respectively, in soluble form were capable of blocking antigen specific clonal T cell responses (4,5). Perhaps more importantly, when coupled to the surface of a solid support these antibodies produced functional effects that were undistinguishable from those produced by the natural ligand of this molecular complex, namely antigen itself (6,7).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Meuer, S.C. et al. Nature 303, 808–810 (1983).
Acuto, O. et al. J. Exp. Med. 158, 1368–1373 (1983).
Borst, J. et al. J. Biol. Chem. 8, 5135–5141 (1983).
Reinherz, E.L. et al. Cell 30, 735–743 (1982).
Meuer, S.C. et al. J. Exp. Med. 157, 705–719 (1983).
Meuer, S.C. et al. J. Exp. Med. 158, 988–993 (1983).
Meuer, S.C. et al. Science 222, 1239–1242 (1983).
Meuer, S.C. et al. Cell 36, 897–906 (1984).
Kaneoka, H. J. Immunol. 131, 158–164 (1983).
Bergholtz, B.O. & Thorsby, E. Scand. J. Immunol. 8, 63–67 (1978).
Todd III, R.F. Human Immunol. 10, 23–40 (1984).
Lachman, L.B. Federation Proc. 42, 2639–2645 (1983).
Conlon, P.J., Henney, C.S. & Gillis, S. J. Immunol. 128, 797–801 (1982).
Cantrel1, D.A. & Smith, K.A. J. Exp. Med. 158, 1895–1911 (1983).
Meuer, S.C. et al. Proc. Natl. Acad. Sci. 81, 1509–1513 (1984).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 The Humana Press Inc.
About this chapter
Cite this chapter
Meuer, S.C. (1985). Pathways and Mechanisms of Human T Cell Activation. In: Feldmann, M., Lamb, J.R., Woody, J.N. (eds) Human T Cell Clones. Experimental Biology and Medicine, vol 9. Humana Press. https://doi.org/10.1007/978-1-4612-4998-6_29
Download citation
DOI: https://doi.org/10.1007/978-1-4612-4998-6_29
Publisher Name: Humana Press
Print ISBN: 978-1-4612-9391-0
Online ISBN: 978-1-4612-4998-6
eBook Packages: Springer Book Archive