Abstract
We have examined several aspects of IFN-
secretion by murine influenza A virus specific cytotoxic T-cell (Tc) clones. IFN-
secretion is H-2 restricted and depends on contact of Tc with antigen (influenza A infected cells). There is an inverse relationship between IFN production and rapid cellular proliferation of Tc but T-cell mitogens induce IFN at all stages of cell growth. Treatment of Tc with recombinant IFN-
had no effect on cytolytic activity of cloned Tc or a Tc line. Nor could we find any effect on generation of influenza specific Tc when recombinant IFN-
is added during the in vitro induction of Tc. Thus we have no evidence that IFN-
affects Tc proliferation or maturation. The influenza system does not lend itself to test IFN-
effects on target cells, since it inhibits influenza virus expression on the cell surface of IFN susceptible cells.
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Askonas, B.A., Pala, P. (1985). Influenza Specific Cytotoxic T-Cell Clones and Immune Interferon. In: Feldmann, M., Lamb, J.R., Woody, J.N. (eds) Human T Cell Clones. Experimental Biology and Medicine, vol 9. Humana Press. https://doi.org/10.1007/978-1-4612-4998-6_35
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DOI: https://doi.org/10.1007/978-1-4612-4998-6_35
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