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Regulation of S-Adenosylmethionine Synthesis in Human Lymphocytes

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Biological Methylation and Drug Design

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 12))

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Abstract

The biochemistry of S-adenosylmethionine (AdoMet) provides several possible strategies for drug design. One focuses on the ability of S-adenosylhomocysteine (AdoHcy) and its analogues to inhibit transmethylation reactions; and involves the design of agents that inhibit transmethylases directly, or inhibit AdoHcy hydrolase causing AdoHcy accumulation, or react intracellularly with homocysteine to form inhibitory analogues of AdoHcy.

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Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, NC, 27710, USA

    Nicholas M. Kredich, Malak Kotb, Deborah Campano German & Craig A. Bloch

Authors
  1. Nicholas M. Kredich
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  2. Malak Kotb
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  3. Deborah Campano German
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  4. Craig A. Bloch
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Editor information

Editors and Affiliations

  1. Pharmaceutical Chemistry Department, The University of Kansas, Lawrence, Kansas, USA

    Ronald T. Borchardt

  2. NIADDK, National Institutes of Health, Bethesda, Maryland, USA

    Cyrus R. Creveling

  3. Department of Pharmacology, University of Bergen, Bergen, Norway

    Per Magne Ueland

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© 1986 The Humana Press Inc.

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Kredich, N.M., Kotb, M., German, D.C., Bloch, C.A. (1986). Regulation of S-Adenosylmethionine Synthesis in Human Lymphocytes. In: Borchardt, R.T., Creveling, C.R., Ueland, P.M. (eds) Biological Methylation and Drug Design. Experimental Biology and Medicine, vol 12. Humana Press. https://doi.org/10.1007/978-1-4612-5012-8_17

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  • DOI: https://doi.org/10.1007/978-1-4612-5012-8_17

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9398-9

  • Online ISBN: 978-1-4612-5012-8

  • eBook Packages: Springer Book Archive

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