Abstract
The synthesis and metabolism of both polyamines and S-adenosyImethionine (Adomet) are important for cell growth regulation. However, our understanding of the regulation of polyamine and Adomet metabol ism in intact mammalian cells is incomplete. 5′-deoxy-5′-methylthioadenosine (abbreviated as MTA or MeSAdo) is the purine end product of the polyamine biosynthetic pathway. Polyamines are organic cations that all dividing cells produce in abundance. Their exact metabolic functions are not known. However, states of increased cellular proliferation, such as cancer, are uniformly associated with accelerated rates of polyamine synthesis (Pegg & McCann, 1982; Heby, et al., 1976.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Backlund, P.S. Jr. and Smith, R.A. (1981) J. Biol. Chem. 256, 1533.
Carrera, C.J., Eddy, R.L., Shows, T.B. and Carson, D.A. (1984) Proc. Natl. Acad. Sei. USA 81, 2665.
Ferro, A.J., Vandenbark, A.A. and MacDonald, M.R. (1981) Biochem, Biophys. Res. Commun., 100, 523.
Galletti, P., Ollva, A., Manna, C, Della Ragione, F. and Cartenl-Farina, M. (1981) FEES Lstt 126 236.
German, D.C., Block, C.A. and Kredich, N.M. (1983) J. Biol chem. 258, 7288.
Heby, O., Marton, L.J., Wilson, C.B., and Martinez, H.M. (1975) J. Cel1. Physiol. 86, 511.
Iizasa, T. and Carson, D.A. (1985) Biochim, Biophys. Acta 844, 280.
Kamatani, N. and Carson, D.A. (1980) Cancer Res, 40, 4178.
Kamatani, N. and Carson, D.A. (1981) Biochim. Biophys. Acta 675, 344.
Kamatani, N. and Carson, D.A. (1982) Intl. Arch Al1ergy App1. Immunol. 68,84.
Kamatani, N., Kubota, M., WilIis, E.H., Frincke, L.A. and Carson, D.A. (1984) Adv. Exp, Med, Biol 165B, 83.
Kamatani, N., Nelson-Rees, W.A. and Carson, D.A. (1981) Proc. Natl. Acad. Sci. USA 78, 1219.
Kubota, M., Kajander, E.O. and Carson, D.A. (1985) Cancer Res., in press.
Kubota, M., Kamatani, N. and Carson, D.A. (1983) J. Biol. Chem. 258, 7822.
Leonard, N.J. and Tolman, G.L. (1975) Ann. N.Y. Acad. Sci. 255, 43.
Mamont, P.S., Joder-Ohlenbusch, A-M, Nussli, M., Grove, J. (1981) Biochem. J.196 411.
Pajula, R.-L., Raina, A. and Eloranta, T. (1979) Eur. J. Biochem. 101, 619.
Pegg, A.E. and McCann, P.P. (1982) Am. J. Physiol. 243, C212.
Pegg, A.E. and Williams-Ashman, H.G. (1969) Biochem. J. 115, 241.
Savarese, T.M., Crabtree, G.W. and Parks, R.E., Jr. (1981) Biochem. Pharmacol., 30, 189.
Schimke, R.T. and Doyle, D. (1970) Ann, Rev. Biochem. 39, 929.
Schlenk, F. (1983) Adv. Enzym. 54, 195.
Sufrin, J.R. and Lombardini, J.B. (1982) Mol.Pharmacol 22 752.
Toohey, J.I. (1977) Biochem. Biophys. Res. Com. 78. 1273.
White, M.W., Resiol, M.K. and Ferro, A.J. (1983) Biochim. Biophys. Acta 762 405.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 The Humana Press Inc.
About this chapter
Cite this chapter
Carson, D.A. et al. (1986). Regulation of S-Adenosylmethionine and Methylthioadenosine Metabolism in Methylthioadenosine Phosphorylase Deficient Malignant Cells. In: Borchardt, R.T., Creveling, C.R., Ueland, P.M. (eds) Biological Methylation and Drug Design. Experimental Biology and Medicine, vol 12. Humana Press. https://doi.org/10.1007/978-1-4612-5012-8_23
Download citation
DOI: https://doi.org/10.1007/978-1-4612-5012-8_23
Publisher Name: Humana Press
Print ISBN: 978-1-4612-9398-9
Online ISBN: 978-1-4612-5012-8
eBook Packages: Springer Book Archive