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The Uptake and Release of 14C-Tryptamine by Rat Brain Slices

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Neurobiology of the Trace Amines
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Abstract

Direct tryptamine (T) effects in the rat brain and in rabbit aortic strips have been reported (Jones, 1982; Stollak and Furchgott, 1983); moreover, in the rat brain, there appear to be distinct T receptors (Kellar and Cascio, 1982; Cascio and Kellar, 1982). It is conceivable, then, that T may be a transmitter in the rat brain. If so, T should be accumulated by a high-affinity uptake system which is sodium-, temperature- and energy-dependent; in addition, depolarization induced release of T should be calcium-dependent (Iversen, 1974; Thoa et al., 1975). The following study was undertaken to determine whether T transport exhibited these characteristics.

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© 1984 The Humana Press Inc.

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Dyck, L.E. (1984). The Uptake and Release of 14C-Tryptamine by Rat Brain Slices. In: Boulton, A.A., Baker, G.B., Dewhurst, W.G., Sandler, M. (eds) Neurobiology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5312-9_19

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  • DOI: https://doi.org/10.1007/978-1-4612-5312-9_19

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9781-9

  • Online ISBN: 978-1-4612-5312-9

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