Abstract
In this paper the application of short-term tests using mammalian cell cultures to examine inhibition of chemical carcinogenesis/mutagenesis will be discussed. The choice of the mammalian cell system was made on the assumption that quantitative data obtained with cultured cells could be reliably extrapolated to the whole animal.
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References
Autrup, H., Essigmann, J.M., Croy, R.G., Trump, B.F., Wogan, G.N., Harris, C.C. (1979): Metabolism of aflatoxin B1 and identification of the major aflatoxin B1-DNA adducts formed in cultured human bronchus and colon. Cancer Res. 39: 694–698.
Benson, A.M., Cha, Y.-N., Bueding, E., Heine, H.S., Talalay, P. (1979): Elevation of extrahe- patic glutathione S-transferase and epoxide hydratase activities by 2(3)-tert-butyl-4-hydroxyanisole. Cancer Res. 59: 2971–2977.
Blumberg, W.E. (1978): Enzymic modification of environmental intoxicants: the role of cytochrome P-450. Quart. Rev. Biophys. II 4: 481–542.
Evans, H.J., O’Riordan, M.L. (1977): Human peripheral blood lymphocytes for the analysis of chromosome aberrations in mutagen tests. In: B.J. Kilbey, M. Legator, W. Nichols, and C. Ramel (eds.), Handbook of Mutagenicity Test Procedures. Amsterdam: Elsevier/North-Holland Biomedical Press, pp. 261–274.
Freese, E.B., Gerson, J., Taber, H., Rhaese, H.J., Freese, E. (1967): Inactivating DNA alterations induced by peroxides and peroxide-producing agents. Mutat. Res. 4: 517–531.
Freese, E., Sklarow, S., Freese, E. (1968): DNA damage caused by antidepressant hydrazines and related drugs. Mutat. Res. 5: 343–348.
Garner, R.C., Wright, C.M. (1975): Binding of [C14] aflatoxin Bx to cellular macromolecules in the rat and the hamster. Chem.-Biol. Interact. 11: 123–131.
German, J. (ed.) (1974): Chromosomes and Cancer. New York: J. Wiley & Sons.
Hollstein, M., McCann, J., Angelosanto, F., Nichols, W.W. (1979): Short-term tests for carcinogens and mutagens. Mutat. Res. 65: 133–226.
Laishes, B.A., Stich, H.F. (1973): Repair synthesis and sedimentation analysis of DNA of human cells exposed to dimethylnitrosamine and activated dimethylnitrosamine. Biochem. Biophys. Res. Commun. 52: 827–833.
Lawley, P.D., Thatcher, C.J. (1970): Methylation of DNA in cultured mammalian cells by MNNG: influence of cellular thiol concentration on extent of methylation and 0-6 guanine as a site of methylation. Biochem. J. 116: 693–707.
Lin, J.K., Miller, J.A., Miller, E.C. (1977): 2,3- Dihydro- 2 - (guan - 7 - yl) - 3 - hydroxy - aflatoxin Bx, a major acid hydrolysis product of aflatoxin B1-DNA or ribosomal RNA adducts formed in hepatic microsome-mediated reactions and in rat liver in vivo. Cancer Res. 37: 4430–4438.
Lo, L. Wei, Stich, H.F. (1978): The use of short-term tests to measure the preventive action of reducing agents on formation and activation of carcinogenic nitroso compounds. Mutat. Res. 57: 57–67.
Magee, P.N., Farber, E. (1962): Toxic liver injury and carcinogenesis; methylation of rat liver nucleic acids by dimethylnitrosamine in vivo. Biochem. J. 83: 114–124.
Mailing, H.V. (1974): Mutagenic activation of dimethylnitrosamine and diethylnitrosamine in the host-mediated assay and the microsomal system. Mutat. Res. 27: 465–472.
Miller, E.C. (1978): Some current perspectives on chemical carcinogenesis in human and experimental animals. Cancer Res. 38: 1479–1496.
Painter, R.B. (1981): DNA synthesis inhibition in mammalian cells as a test for mutagenic carcinogens. In: H.F. Stich and R.H.C. San (eds.), Short-Term Tests for Chemical Carcinogens. New York: Springer-Verlag, pp. 59–64.
Rasmussen, R.E., Painter, R.B. (1966): Radiation-stimulated DNA synthesis in cultured mammalian cells. J. Cell Biol. 29: 11–19.
Sarasin, A.R., Smith, C.A., Hanawalt, P.C. (1977): Repair of DNA in human cells after treatment with activated aflatoxin B1, Cancer Res. 37: 1786–1793.
Schulz, U., McCalla, D.R. (1969): Reaction of cysteine with N-methyl-N-nitroso-p-toluene-sulphonamide and MNNG. Can. J. Chem. 47: 2021–2027.
Seiler, J.P. (1981): The testicular DNA-synthesis inhibition test (DSI-test). In: H.F. Stich and R.H.C. San (eds.), Short-Term Tests for Chemical Carcinogens. New York: Springer-Verlag, pp. 94–107.
Skov, K.A., Vonderschmitt, D.J. (1975): Kinetics of iron and copper catalysis of ascorbate oxidation. Bioinorg. Chem. 4: 199–213.
Stein, G.H., Yanishevsky, R. (1979): Au-toradiography. In: W.B. Jakohy and I.H. Pastan (eds.), Methods in Enzymology, Vol. 58. New York: Academic Press, pp. 279–292.
Stich, H.F. Laishes, B.A. (1973): DNA repair and chemical carcinogens. In: H.L. Ioachim (ed.), Pathobiology Annual. New York: Appleton-Century-Crofts, pp. 341–376.
Stich, H.F., Kieser, D., Laishes, B.A., San, R.H.C. (1974): The use of DNA repair in the identification of carcinogens, precarcinogens, and target tissue. In: P.G. Scholefield (ed.), Proceedings of the Tenth Canadian Cancer Conference. University of Toronto Press, Toronto, pp. 83–110.
Stich, H.F., Laishes, B.A. (1975): The response of xeroderma pigmentosum cells and controls to the activated mycotoxins, aflatoxins and sterigmatocystin. Int. J. Cancer 76: 266–274.
Stich, H.F., San, R.H.C., Lam, P.P.S., Koropatnick, D.J., Lo, L.W., Laishes, B.A. (1976a): DNA fragmentation and DNA repair as an in vitro and in vivo assay for chemical precar-cinogens, carcinogens and carcinogenic nitrosation products. In: R. Montesano, H. Bartsch, and L. Tomatis (eds.), Screening Tests in Chemical Carcinogenesis (IARC Scientific Publications No. 12 ). Lyon: International Agency for Research on Cancer, pp. 617–636.
Stich, H.F., Karim, J., Koropatnick, J., Lo, L.W. (1976b): Mutagenic action of ascorbic acid. Nature (Lond.) 260: 722–724.
Stich, H.F., Wei, L., Whiting, R.F. (1979): The enhancing effect of transition metals on the chromosome damaging action of ascorbate. Cancer Res. 39: 4145–4151.
Swann, P.F., Magee, P.N. (1971): Nitrosamine-induced carcinogenesis. The alkylation of N-7 of guanine of nucleic acids of the rat by diethylnitrosamine, N-ethyl-N-nitrosourea and ethyl methanesulfonate. Biochem. J. 125: 841–847.
Ts’o, P.O.P., Caspary, W.T., Lorentzen, R.J. (1977): Involvement of free radicals in chemical carcinogenesis. In: W.A. Pryor (ed.), Free Radicals in Biology, Vol. III. New York: Academic Press, pp. 251–303.
Whiting, R.F., Wei, L., Stich, H.F. (1979): Enhancement by transition metals of unscheduled DNA synthesis induced by isoniazid and related hydrazines in cultured normal and xeroderma pigmentosum human cells. Mutat. Res. 62: 505–515.
Whiting, R.F., Wei, L., Stich, H.F. (1980): Enhancement by transition metals of chromo-some aberrations induced by isoniazid. Bio-chem. Pharmacol. 29: 842–845.
Wogan, G.N. (1973): Aflatoxin carcinogenesis. In: H. Busch (ed.), Methods in Cancer Re-search, Vol. I. New York: Academic Press, pp. 309–344.
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Wei, L., Whiting, R.F., Stich, H.F. (1981). Inhibition of Chemical Mutagenesis: An Application of Chromosome Aberration And DNA Synthesis Assays Using Cultured Mammalian Cells. In: Stich, H.F., San, R.H.C. (eds) Short-Term Tests for Chemical Carcinogens. Topics in Environmental Physiology and Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5847-6_38
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DOI: https://doi.org/10.1007/978-1-4612-5847-6_38
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