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Infection and Endocrine Autoimmunity

  • Chapter
Microorganisms and Autoimmune Diseases

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Abstract

Autoimmunity is among the most common causes of endocrine disease, and indeed the first demonstration that autoimmune responses could be induced in animals came with studies on the thyroid gland. Since then it has become apparent that the body normally avoids autoimmune disease by a hierarchy of defense mechanisms, ranging from clonal deletion through clonal anergy to active suppression, and the molecular mechanisms responsible are now being unraveled.1 It is also clear that autoimmune endocrine disorders arise in genetically predisposed individuals, but additional, probably environmental factors also contribute to susceptibility.2

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Authors and Affiliations

  1. Department of Medicine, Clinical Sciences Centre, Northern General Hospital, Sheffield, S5 7AU, England

    Anthony P. Weetman

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  1. College of Medicine, University of South Florida, Tampa, Florida, USA

    Herman Friedman

  2. School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland, USA

    Noel R. Rose

  3. University of Pisa, Pisa, Italy

    Mauro Bendinelli

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© 1996 Plenum Press, New York

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Weetman, A.P. (1996). Infection and Endocrine Autoimmunity. In: Friedman, H., Rose, N.R., Bendinelli, M. (eds) Microorganisms and Autoimmune Diseases. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0347-3_12

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  • DOI: https://doi.org/10.1007/978-1-4613-0347-3_12

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