Abstract
Because of the direct relationship between the efficacy of alcohols and other anesthetics with their oil/water partition coefficients, most research concerning the mechanism of action of ethanol has focused on the disruptive effects of the alcohol on the molecular order in the interior of neuronal and model membrane systems. The observed changes are, however, small and alone cannot explain the total pharmacological actions of alcohols1. Recent studies have shown that ethanol and other anesthetics not only interact with the interior of the membrane but also interact with the surface domain2–6.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
E. Rubin, “Alcohol and the Cell”, Anal. N.Y. Acad. Sci., New York (1987).
G. P. Kreishman, C. Graham-Brittain, and R. J. Hitzemann, Determination of Ethanol Partition Coefficients to the Interior and the Surface of Dipalmityl-Phosphatidyl Choline Liposomes Using Deuterium Nuclear Magnetic Resonance Spectroscopy, Biochem. Biophys. Res. Commun. 130: 301 (1985).
R. J. Hitzemann, H. E. Schueler, C. Grahama-Brittain and G. P. Kreishman, Ethanol-Induced Changes in Neuronal Membrane Order; An NMR Study, Biochem. Biophys. Acta 859: 189 (1986).
J. Figueirinhas and P. W. Westerman, Direct Observation of Ethanol Binding to Phospholipid Bilayers, A 2H NMR Study, Biophys. J., 55: 324a (1989).
L. R. De Young and K. A. Dill, Solute Partitioning in Lipid Bilayer Membranes, Biochemistry 27: 5281 (1988).
A. S. Avers, B. A. Berkowitz and D. A. d’Avignon, Correlation between the Anaesthetic Effect of Halothane and Saturable Binding in Brain, Nature 328: 157 (1987)
R. J. Hitzemann, C. Graham-Brittain, H. E. Schueler and G. P. Kreishman, Ordering/Disordering Effects of Ethanol in Dipalmitoyl Phophatidyl Choline Liposomes, Anal. N.Y. Acad. Sci. 492: 142 (1986).
R. A. Harris, L. M. Zaccaro, S. McQuilkin and A. McClard, Effects of Ethanol and Calcium on Lipid Order of Membranes from Mice Selected for Genetic Differences in Ethanol Intoxication, Alcohol 5: 251 (1988).
E. Rowe, Lipid Chain Length and Temperature Dependence of Ethanol-Phosphatidylcholine Interactions, Biochemistry 22: 3299 (1983).
E. S. Rowe, Thermodynamic Reversibility of Phase Transitions, Specific effects of alchols on phosphatidyl cholines, Biochim. Biophys. Acta 813: 321 (1985).
K. A. Dill and D. Stigter, Lateral Interactions among Phosphatidylcholine and Phosphatidylethanolamine Head Groups in Phospholipid Monolayers and Bilayers, Bochemistry, 27: 3446 (1988).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Kreishman, G.P. (1989). Theoretical Modeling of the Ethanol Induced Changes in the Lateral Interactions of the Ionic Head Groups of Phosphatidylcholine at the Water-Lipid Interface. In: Allen, M.J., Cleary, S.F., Hawkridge, F.M. (eds) Charge and Field Effects in Biosystems—2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0557-6_11
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0557-6_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-7865-8
Online ISBN: 978-1-4613-0557-6
eBook Packages: Springer Book Archive