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Pathogenesis of Hypertriglyceridemia: Implications for Coronary Heart Disease and Therapy

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Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 243))

Abstract

The role of hypertriglyceridemia in the causation of coronary heart disease (CHD) is a subject of continuing controversy. Sonne investigatory hold that hypertriglyceridemia constitutes a major risk factor for CHD, but others claim the opposite, namely, that elevated triglyceride levels are of little significance for CHD risk* The very fact that so many experienced investigators hold such divergent views attests to the complexity of the issue. The crux of the problem appears to be that a high proportion of patients with CHD have hypertriglyceridemia, and yet high triglycerides per se are not a major causative factor; instead, elevated plasma triglycerides frequently appear to be associated with other atherogenic factors that have not been fully defined. This paper will examine the complexity of the hypertriglyceridemic state, and it will consider the following questions: (a) what are the basic pathways of triglyceride metabolism in humans? (b) what are the causes of hypertriglyceridemia? (c) what is the relation of hypertriglyceridemia to CHD?, and (d) what constitutes a rational approach to the treatment of hypertriglyceridemia?

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Authors and Affiliations

  1. University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas, 75235-9052, USA

    Gloria Lena Vega & Scott M. Grundy

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  1. Gloria Lena Vega
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  2. Scott M. Grundy
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Editors and Affiliations

  1. Research Foundation on Atherosclerosis, Brussels, Belgium

    Claude L. Malmendier

  2. The Free University of Brussels, Brussels, Belgium

    Claude L. Malmendier

  3. Lipoprotein and Atherosclerosis Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA

    Petar Alaupovic

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© 1988 Plenum Press, New York

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Vega, G.L., Grundy, S.M. (1988). Pathogenesis of Hypertriglyceridemia: Implications for Coronary Heart Disease and Therapy. In: Malmendier, C.L., Alaupovic, P. (eds) Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 243. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0733-4_39

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  • DOI: https://doi.org/10.1007/978-1-4613-0733-4_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8055-2

  • Online ISBN: 978-1-4613-0733-4

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