Abstract
Glucosylceramidase (EC 3.2.1.45) is a membrane-bound, lysosomal enzyme, which hydrolyzes glucosylceramide into glucose and ceramide (1). As for several other glycosphingolipid hydrolses, also for glucosylceramidase a special activator protein capable of stimulating its activity has been described in the past (2–5). It is mainly present in human spleen and, for this reason, has been called “Gaucher factor”. It is a water soluble protein with a molecular weight of about 13,000 Da (5).
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© 1988 Plenum Press, New York
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Vaccaro, A.M., Muscillo, M., Salvioli, R., Tatti, M., Gallozzi, E. (1988). The Role of a New Glucosylceramidase Activator Protein in the Binding of the Enzyme to its Natural Substrate. In: Salvayre, R., Douste-Blazy, L., Gatt, S. (eds) Lipid Storage Disorders. NATO ASI Series, vol 150. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1029-7_42
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DOI: https://doi.org/10.1007/978-1-4613-1029-7_42
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