Skip to main content

Abstract

The antimetabolites constitute a large group of anticancer drugs that interfere with metabolic processes vital to the physiology and proliferation of cancer cells. The major classes of the antimetabolites are the antifols, the purine analogues, and the pyrimidine analogues [1–4].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Chabner BA, Collins JM (eds): Cancer Chemotherapy: Principles and Practice. Philadelphia: JB Lippincott; 1990.

    Google Scholar 

  2. Chen AP, Grem JL: Antimetabolites. Curr Opin Onco11992, 4: 1089 - 1098.

    Google Scholar 

  3. Cheson BD: New antimetabolites in the treatment of human malignancies. Sem Once/ 1992, 19: 695 - 706.

    CAS  Google Scholar 

  4. Clarke SJ, Jackman AL, Harrap KR: Antimetabolites in cancer chemotherapy. Adv Exp Biol Med 1991, 309A: 7 - 13.

    Google Scholar 

  5. Dan-y MA, Behnke CA, Eastman A: Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins, and hyperthermia. Biochem Pharmaco11990, 40: 2353 - 2362.

    Google Scholar 

  6. Averette H, Boike G, Jarrell M: Effects of cancer chemotherapy on gonadal function and reproductive capacity. CA Cancer J Clin 1990, 40: 199 - 209.

    Article  PubMed  CAS  Google Scholar 

  7. Grem JL, Chu E, Boarman D, et al.: Biochemical modulation of fluorouracil with leucovorin and interferon: preclinical and clinical investigations. Sem Onco11992, 2(suppl 3):36-44.

    Google Scholar 

  8. Ullman B, Lee M, Martin DW, Santi DV: Cytotoxicity of 5-fluoro2-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate. Proc Nat Acad Sci U S A 1978, 75: 980 - 983.

    Article  CAS  Google Scholar 

  9. Poon MA, O’Connell MJ, Wieand HS, et al.: Biochemical modulation of fluorouracil with leucovorin: confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer. J Clin Onco11991, 9:1967-1972.

    Google Scholar 

  10. Presant C, Wolf W, Albright MJ, et al.: Human tumor fluorouracil trapping: Clinical correlations of in vivo 19F nuclear magnetic resonance spectroscopy pharmacokinetics. J Clin Once 1990, 8:1868-1873.

    Google Scholar 

  11. Buchi KN, Moore JG, Hrushesky WJ, et al.: Circadian rhythm of cellular proliferation in the human rectal mucosa. Gastroenterology 1991, 101:410-415.

    Google Scholar 

  12. Von Roemeling R, Hrushesky WJ: Circadian patterning of continuous floxuridine infusion reduces toxicity and allows higher dose intensity in patients with widespread cancer. J Clin Once! 1989, 7: 1710 - 1719.

    Google Scholar 

  13. Trippett TM, Bertino JR: Therapeutic strategies targeting proteins that regulate folate and reduced folate transport./ Chemother 1999, 11: 3 - 10.

    CAS  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer Science+Business Media New York

About this chapter

Cite this chapter

Chiao, J., Beitz, J., DeLap, R.J. (2001). Antimetabolic Agents. In: Current Cancer Therapeutics. Current Medicine Group, London. https://doi.org/10.1007/978-1-4613-1099-0_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1099-0_2

  • Publisher Name: Current Medicine Group, London

  • Print ISBN: 978-1-57340-176-0

  • Online ISBN: 978-1-4613-1099-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics