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Inositolpolyphosphates and their binding proteins — a short review

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Biochemistry of Signal Transduction in Myocardium

Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 17))

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Abstract

Since 1983, when it was discovered that inositol 1,4,5-trisphosphate can act as second messenger to release Ca2+ from the endoplasmic reticulum, widespread research has focused on the phosphatidylinositol signalling transduction pathway and the host of inositolphosphates formed intracellularly after stimulation thereof. Although the polyphosphates, inositol-tetrakisphosphate (InsP4) and inositolhexakisphosphate (InsP6), have received their share of attention, a definite physiological role has not been ascribed to them as yet. Different binding proteins for these two polyphosphates have been demonstrated, especially in brain tissue, indicating their possible importance in the cell.

InsP6 is known as one of nature’s most powerful antioxidants and has already been demonstrated to possess the abilities to be of use in the industry as well as in the medical profession. As its natural actions are poorly understood and its possible side-effects have not been widely investigated, basic research regarding its cellular and subcellular activities is urgently called for.

Recipient of Servier Investigator Award

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Authors and Affiliations

  1. Department of Medical Physiology and Biochemistry, Faculty of Medicine, University of Stellenbosch, MRC Programme for Experimental Biology, PO Box 19063, Tygerberg, 7505, Republic of South Africa

    Barbara Huisamen & Amanda Lochner

Authors
  1. Barbara Huisamen
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  2. Amanda Lochner
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Editor information

Editors and Affiliations

  1. Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine of Health Science, Erasmus University Rotterdam, P.O. Box 1738, 3300 DR, Rotterdam, The Netherlands

    Jos M. J. Lamers

  2. Department of Cardiology, Cardiovascular Research Institute COEUR, Erasmus University Rotterdam, P.O. Box 1738, 3300 DR, Rotterdam, The Netherlands

    Pieter D. Verdouw

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© 1996 Kluwer Academic Publishers

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Huisamen, B., Lochner, A. (1996). Inositolpolyphosphates and their binding proteins — a short review. In: Lamers, J.M.J., Verdouw, P.D. (eds) Biochemistry of Signal Transduction in Myocardium. Developments in Molecular and Cellular Biochemistry, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1275-8_29

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  • DOI: https://doi.org/10.1007/978-1-4613-1275-8_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8544-1

  • Online ISBN: 978-1-4613-1275-8

  • eBook Packages: Springer Book Archive

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