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Adrenergic and muscarinic receptor regulation and therapeutic implications in heart failure

  • Chapter
Biochemistry of Signal Transduction in Myocardium

Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 17))

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Abstract

In end-stage heart failure the expression of different myocardial regulatory proteins involved in the β-adrenergic cAMP signalling pathway is altered. The downregulation of β1-adrenoceptors and their uncoupling from the effector as well as an increased expression of the inhibitory GTP-binding protein seem to be the most important alterations. Since catecholamine levels are elevated in these patients and since some alterations can be ‘restored’ after treatment with β-adrenoceptor antagonists it was hypothesized that excessive β-adrenergic stimulation could be involved in these alterations.

In this article the changes of β-adrenergic receptors, GTP-binding proteins, sarcoplasmic reticulum Ca2+-ATPase and of phospholamban found in heart failure are addressed with its possible therapeutic implications.

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  1. Institut für Pharmakologie und Toxikologie, Westfälische Wilhelms-Universität, Domagkstr. 12, 48149, Münster, Germany

    Wilhelm Schmitz, Peter Boknik, Bettina Linck & Frank U. Müller

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  1. Wilhelm Schmitz
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  2. Peter Boknik
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  3. Bettina Linck
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  4. Frank U. Müller
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  1. Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine of Health Science, Erasmus University Rotterdam, P.O. Box 1738, 3300 DR, Rotterdam, The Netherlands

    Jos M. J. Lamers

  2. Department of Cardiology, Cardiovascular Research Institute COEUR, Erasmus University Rotterdam, P.O. Box 1738, 3300 DR, Rotterdam, The Netherlands

    Pieter D. Verdouw

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Schmitz, W., Boknik, P., Linck, B., Müller, F.U. (1996). Adrenergic and muscarinic receptor regulation and therapeutic implications in heart failure. In: Lamers, J.M.J., Verdouw, P.D. (eds) Biochemistry of Signal Transduction in Myocardium. Developments in Molecular and Cellular Biochemistry, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1275-8_33

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  • DOI: https://doi.org/10.1007/978-1-4613-1275-8_33

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