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Opioid Peptides: Possible Physiological Role as Endogenous Anticonvulsants

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Neurobiology of Amino Acids, Peptides and Trophic Factors

Part of the book series: Topics in the Neurosciences ((TINS,volume 8))

Abstract

Among the most poorly understood and possibly least appreciated pharmacological actions of opioids (morphine, its congeners, and the enkephalins, endorphins, and dynorphins) is their effect on central nervous system (CNS) excitability relative to seizure states. Clinical reports dating back to the turn of the century describe proconvulsant and anticonvulsant actions of morphine in man [1]. Experimentally, a similar paradox exists wherein the convulsant properties of opioids in numerous species were recognized as early as 1824, while their anticonvulsant actions have also been repeatedly documented since the nineteenth century [1].

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    James A. Ferrendelli , Robert C. Collins  & Eugene M. Johnson ,  & 

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Tortella, F.C. (1988). Opioid Peptides: Possible Physiological Role as Endogenous Anticonvulsants. In: Ferrendelli, J.A., Collins, R.C., Johnson, E.M. (eds) Neurobiology of Amino Acids, Peptides and Trophic Factors. Topics in the Neurosciences, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1721-0_12

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