Abstract
Coronary artery reperfusion by means of thrombolytic therapy, percutaneous transluminal angioplasty, or bypass surgery is rapidly emerging as the fundamental strategy in the management of acute ischemic syndromes in patients with coronary artery disease. The explosive growth of interventional recanalization, coupled with the widespread recognition that spontaneous reperfusion occurs commonly following coronary artery spasm or thrombosis, has provided the impetus to investigate the consequences of restoring blood flow to the ischemic myocardium. Experimental studies have demonstrated that although early reperfusion limits infarct size, this beneficial effect does not lead to immediate functional improvement; rather, the return of contractility in tissue salvaged by reperfusion is delayed for hours, days or even weeks (1–9), a phenomenon that has been termed “stunned myocardium” (10).
This study was supported in part by Grant-in-Aid 85G-225 from the American Heart Association, Texas Affiliate, Austin, Texas.
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Bolli, R., Roberts, R. (1988). Role of Oxy-Radicals in Postischemic Myocardial Dysfunction. In: Singal, P.K. (eds) Oxygen Radicals in the Pathophysiology of Heart Disease. Developments in Cardiovascular Medicine, vol 86. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1743-2_14
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