Abstract
Fibrinogen adsorption and platelet adhesion studies were done on modified polyetherurethane urea vascular grafts fabricated by precipitation method on clean glass rods. Surface modification was done by immobilizing heparin and PGI2 analog on albuminated polymer substrate. The results indicated that although these biologically modified surfaces adsorbed more fibrinogen, the platelet adherence was less. Therefore the antiplatelet activity of the immobilized biomolecules should also be given attention while interpreting the fibrinogen-platelet interrelationship towards thrombogenicity.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Refernces
L. Vroman, A. Adams, M. Klings, G. Fischer, P. Munos and R. Solensky, Ann. N.Y. Acad. Sci., 283, 65–76 (1977).
D. J. Lyman, L. C. Metealf, D. Albo, Jr., K. F. Richards and J. Lamb, Trans. Am. Soc. Artif. Intern. Organs., 20B, 474 (1974).
E. S. Lee and S. W. Kim, Trans. Am. Soc. Artif. Intern. Organs., 25, 124–131 (1979).
R. E. Baier, Ann. N.Y. Acad. Sci., 283, 17–36 (1977).
M. B. Zucker and L. Vroman, Proc. Soc. Exp. Biol. Med., 131. 318–320 (1969).
C. P. Sharma, Current Science, 52, 1057–1058 (1983).
C. P. Sharma and G. Kurien, J. Coll. Inter. Sci., 97 (1), 38–40 (1984).
C. P. Sharma and T. Chandy, J. Coll. Inter. Sci., 89, 479 (1982).
George Joseph and C. P. Sharma, Communicated to the Journal of Biomedical Mat. Research.
C. P. Sharma and N. V. Nirmala, J. Coll. Inter. Sci., 101 (2), 591 (1984).
C. P. Sharma and George Joseph “Protein adsorption on PGE1 immobilized albuminated Biomer”, accepted for presentation at the 5th International conference on surface and Colloid Science, Symposium on Protein and Polyelectrolyte Adsorption, Potsdam, New York, June 24–28, 1985.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Sharma, C.P., Joseph, G. (1987). Fibrinogen/Platelet Interaction with PGI2 Analog-Heparin Immobilized Albuminated Polyurethane. In: Gebelein, C.G. (eds) Advances in Biomedical Polymers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1829-3_22
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1829-3_22
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9022-3
Online ISBN: 978-1-4613-1829-3
eBook Packages: Springer Book Archive