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Nicotinic Cholinergic Receptor Recognition Sites in Brain

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Tobacco Smoking and Nicotine

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 31))

Abstract

Nicotinic cholinergic receptors in the mammalian central nervous system have eluded the exquisitely detailed characterization that has been achieved for the nicotinic receptors in the electric organs of fish and in the mammalian neuromuscular junction. Although radioactively labeled alpha-bungarotoxin -which has been instrumental in studies of the electric organ and muscle receptor -binds to sites in mammalian brain, the toxin itself does not appear to affect nicotinic cholinergic receptor mediated neurotransmission in the mammalian CNS, and the binding sites in brain do not appear to have certain characteristics expected of a functional nicotinic cholinergic receptor (Duggan et al., 1976a; 1976b; Carbonetto et al., 1978). The lack of a suitable probe for the CNS nicotinic cholinergic receptor has been a major obstacle to understanding the molecular pharmacology and neurobiology of these receptors, their effector mechanisms, their regulation, and their possible role in physiological and pathophysiological processes.

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Authors and Affiliations

  1. Department of Pharmacology, Georgetown University Schools of Medicine and Dentistry, 3900 Reservoir Road, N.W., Washington, D.C., 20007, USA

    Kenneth J. Kellar, Rochelle D. Schwartz & Andrea M. Martino

Authors
  1. Kenneth J. Kellar
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  2. Rochelle D. Schwartz
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  3. Andrea M. Martino
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, University of Kentucky, Lexington, Kentucky, 40536, USA

    William R. Martin

  2. Department of Medicine, Veterans Administration Medical Center University of Kentucky, Lexington, Kentucky, 40511, USA

    Glen R. Van Loon

  3. Department of Pharmacology College of Medicine, University of Kentucky, Lexington, Kentucky, 40536, USA

    Edgar T. Iwamoto

  4. The Tobacco and Health Research Institute, University of Kentucky, Lexington, Kentucky, 40536, USA

    Edgar T. Iwamoto

  5. Tobacco and Health Research Institute, University of Kentucky, Lexington, Kentucky, 04546-0236, USA

    Layten Davis (Director) (Director)

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© 1987 Plenum Press, New York

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Kellar, K.J., Schwartz, R.D., Martino, A.M. (1987). Nicotinic Cholinergic Receptor Recognition Sites in Brain. In: Martin, W.R., Van Loon, G.R., Iwamoto, E.T., Davis, L. (eds) Tobacco Smoking and Nicotine. Advances in Behavioral Biology, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1911-5_30

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  • DOI: https://doi.org/10.1007/978-1-4613-1911-5_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9063-6

  • Online ISBN: 978-1-4613-1911-5

  • eBook Packages: Springer Book Archive

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