Skip to main content
SpringerLink
Log in

Antigenic Requirements for the Recognition of Moloney Murine Leukemia Virus-Induced Tumors by Cytotoxic T Lymphocytes

  • Chapter
Development and Recognition of the Transformed Cell

  • 32 Accesses

Abstract

During viral transformation and/or infection, antigenic changes occur on the surface of transformed and infected cells that initiate a variety of cellular as well as humoral immune responses. A major component of this cellular immune response is the generation of cytotoxic T lymphocytes (CTL) which are capable of specifically recognizing and then lysing transformed or infected cells. Analysis of the specificity of these CTL has shown that immune recognition of virus-encoded antigens expressed as integral membrane proteins on the surface of these cells is in association with the class I major histocompatibility antigens H-2K, D, and L.(1–3) Target cells must not only express the appropriate viral antigen but must also express the same class I major histocompatibility antigen (H-2K, D, and L) as the effector CTL. This phenomenon is referred to as H-2-restricted, CTL recognition. This associative recognition (viral + H-2 antigens) required for CTL recognition contrasts with the recognition of antigen alone by antibody and has made it difficult to precisely define the antigenic determinants recognized by H-2-restricted, virus-specific CTL.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Shearer, G. M., Rehn, T. G., and Schmitt-Verhulst, A. M., 1976, Role of the murine major histocompatibility complex in the specificity of in vitro T-cell mediated lympholysis against chemically modified autologous lymphocytes, Transplant. Rev. 29:222–248.

    PubMed  CAS  Google Scholar 

  2. Doherty, P. C., Blanden, R. O., and Zinkernagel, R. M., 1976, Specificity of virus immune effector cells for H-2K and H-2D compatible interactions: Implications for H-2 antigen diversity, Transplant. Rev. 29:89–124.

    PubMed  CAS  Google Scholar 

  3. Zinkernagel, R. M., 1978, Thymus and lymphohemopoietic cells: Their role in T cell maturation in selection of T cells, H-2 restriction specificity and in H-2 linked Ir-gene control, Immunol. Rev. 42:224–270.

    Article  PubMed  CAS  Google Scholar 

  4. Levy, J. P., and Leclerc, J. C., 1977, The murine sarcoma virus-induced tumor: Exception or general model in tumor immunology? Adv. Cancer Res. 24:1–66.

    Article  PubMed  CAS  Google Scholar 

  5. Plata, F., MacDonald, H. R., and Sordat, B., 1975, Studies on the distribution and origin of cytolytic T lymphocytes present in mice bearing Moloney murine sarcoma (MSV)-induced tumors, Bibl. Haematol. 43:274–281.

    PubMed  Google Scholar 

  6. Plata, F., and Sordat, B., 1977, Murine sarcoma virus (MSV)-induced tumors in mice. I. Distribution of MSV-immune cytolytic T lymphocytes in vivo, Int. J. Cancer 19:205–214.

    Article  PubMed  CAS  Google Scholar 

  7. Plata, F., Cerottini, J.-C., and Brunner, K. T., 1975, Primary and secondary in vitro generation of cytotoxic T lymphocytes in the murine sarcoma virus system, Eur. J. Immunol. 5:227–233.

    Article  PubMed  CAS  Google Scholar 

  8. Fefer, A., McCoy, J. L., and Glynn, J. P., 1967, Antigenicity of virus-induced murine sarcoma (Moloney), Cancer Res. 27:962–971.

    PubMed  CAS  Google Scholar 

  9. Stephenson, J. R., and Aronson, S. A., 1972, Oncogenic properties of murine sarcoma virus-transformed BALB/C-3T3 nonproducer cells, J. Exp. Med. 135:503–514.

    Article  PubMed  CAS  Google Scholar 

  10. Law, L. W., and Ting, R. C., 1970, Antigenic properties of a nonreleaser neoplasm induced in the mouse by mature sarcoma virus, J. Natl. Cancer Inst. 44:615–623.

    PubMed  CAS  Google Scholar 

  11. Pinter, A., and Honnen, W. J., 1983, Topography of murine leukemia virus envelope proteins: Characterization of transmembrane components, J. Virol. 46:1056–1060.

    PubMed  CAS  Google Scholar 

  12. Lentz, J., Crowther, R., Straceski, A., and Haseltine, A., 1982, Nucleotide sequence of the AKV envgene, J. Virol. 42:519–529.

    Google Scholar 

  13. Pinter, A., and Fleissner, E., 1977, The presence of disulfide-linked gp70-p15(E) complexes in AKV-MuLV, Virology 83:417–422.

    Article  PubMed  CAS  Google Scholar 

  14. Pinter, A., Lieman-Hurwitz, J., and Fleissner, E., 1978, The nature of the association between the murine leukemia virus envelope proteins, Virology 91:345–351.

    Article  PubMed  CAS  Google Scholar 

  15. Cicurel, L., Lee, J. C., Enjuanes, L. E., and Ihle, J. N., 1980, Monoclonal antibodies to the envelope protein of Moloney leukemia virus: Characterization of recombinant viruses, Transplant. Proc. 12:394–397.

    PubMed  CAS  Google Scholar 

  16. DeLarco, J., and Todaro, G. J., 1976, Membrane receptors for murine leukemia viruses: Characterization using purified viral envelope glycoprotein, gp71, Cell 8:365–371.

    Article  PubMed  CAS  Google Scholar 

  17. Crawford, S., and Goff, S. P., 1985, A deletion mutation in the 5’ part of the pol gene on Moloney murine leukemia virus blocks proteolytic processing of the gag gene and pol polyproteins, J. Virol. 53:899–907.

    PubMed  CAS  Google Scholar 

  18. Edwards, S. A., and Fan, H., 1979, gag-related polyproteins of Moloney murine leukemia virus: Evidence for independent synthesis of glycosylated and unglycosylated forms, J. Virol. 30:551–563.

    PubMed  CAS  Google Scholar 

  19. Edwards, S. A., and Fan, H., 1980, Sequence relationship of glycosylated and unglycosylated gag polyproteins of Moloney murine leukemia virus, J. Virol. 35:41–51.

    PubMed  CAS  Google Scholar 

  20. Ledbetter, J. A., Nowinski, R., and Eisenman, R. N., 1978, Biosynthesis and metabolism of viral proteins expressed on the surface of murine leukemia virus infected cells, Virology 91:116–129.

    Article  PubMed  CAS  Google Scholar 

  21. Arcement, J. L., Karshin, W. I., Naso, R. B., and Arlinghaus, R. B., 1977, “Gag” polyprotein precursors of Rauscher murine leukemia virus, Virology 81:284–297.

    Article  PubMed  CAS  Google Scholar 

  22. Schultz, A. M., Rabin, E. H., and Oroszlan, S., 1979, Post-translational modification of Rauscher leukemia virus precursor polyproteins encoded by the gag gene, J. Virol. 30:255–266.

    PubMed  CAS  Google Scholar 

  23. Schwartzenberg, P., Colicelli, J., and Goff, S. P., 1983, Deletion mutants of Moloney leukemia virus which lack glycosylated gag protein are replication competent, J. Virol. 46:538–546.

    Google Scholar 

  24. Enjuanes, L., Lee, J. C., and Ihle, J. N., 1979, Antigenic specificities of the cellular immune response of C56BL/6 mice to the Moloney leukemia sarcoma virus complex, J. Immunol. 122:665–674.

    PubMed  CAS  Google Scholar 

  25. Collins, J. K., Britt, W. J., and Chesebro, B., 1980, Cytotoxic T Lymphocyte recognition of gp70 on Friend virus-induced erythroleukemia cell clones, J. Immunol. 125:1318–1324.

    PubMed  CAS  Google Scholar 

  26. Gomard, E., Levy, J. P., Plata, F., Henin, Y., Duprez, V., Bismuth, A., and Reme, T., 1978, Studies on the nature of the cell surface antigen reacting with cytolytic T lymphocytes in murine on cornavirus-induced tumor cells, Eur. J. Immunol. 8:228–236.

    Article  PubMed  CAS  Google Scholar 

  27. Flyer, D. C., BurakofF, S. J., and Faller, D. V., 1983, Cytotoxic T lymphocyte recognition of transfected cells expressing a cloned retroviral gene, Nature (Lond.) 305:815–818.

    Article  CAS  Google Scholar 

  28. Flyer, D. C., Burakoff, S. J., and Faller, D. V., 1985, Expression and CTL recognition of cloned subgenomic fragments of Moloney murine leukemia virus in murine cells, Surv. Immunol. Res. 4:168–172.

    PubMed  CAS  Google Scholar 

  29. van der Hoorn, F. A., Lahaye, T., Muller, V., Ogle, M. A., and Engers, H. D., 1985, Characterization of gp85gag as an antigen recognized by Moloney leukemia virus-specific cytolytic T cell clones that function in vivo, J. Exp. Med. 162:128–144.

    Article  PubMed  Google Scholar 

  30. Plata, F., Kalil, J., Zilber, M-T., Fellous, M., and Levy, D., 1984, Identification of a viral antigen recognized by H-2 restricted cytolytic T lymphocytes on a murine leukemia virus-induced tumor, J. Immunol. 131:2551–2556.

    Google Scholar 

  31. Abastado, J.-P., Plata, F., Morello, D., Daniel-Vedele, F., and Kourilsky, P., 1985, H-2 restricted cytolysis of L cells doubly transformed with a cloned H-2Kb gene and cloned retroviral DNA, J. Immunol. 135:3512–3519.

    PubMed  CAS  Google Scholar 

  32. Plata, F., Tilkin, A. F., Levy, J. P., and Lilly., F., 1981, Quantitative variations in the expression of H-2 antigens on murine leukemia virus-induced tumor cells can effect the H-2 restriction patterns of tumor-specific cytolytic T lymphocytes, J. Exp. Med. 154:1795–1810.

    Article  PubMed  CAS  Google Scholar 

  33. Kuppers, R. C., Ballas, Z. K., Green, W. R., and Henney, C. S., 1981, Quantitative appraisal of H2 products in T cell-mediated lysis by allogeneic and syngeneic effector cells, J. Immunol. 127:500–504.

    PubMed  CAS  Google Scholar 

  34. Gomard, E., Duprez, V., Hemin, Y., and Levy, J. P., 1976, H-2 region products are determinant in immune cytolysis of syngeneic tumor cells by anti-MSV T lymphocytes. Nature (Lond.) 260:707–710.

    Article  CAS  Google Scholar 

  35. Gomard, E., Duprez, V., Reme, T., Colombani, J. M, and Levy, J. P., 1977, Exclusive involvement of H-2Db or H-2Kd product in the interaction between T-killer lymphocytes and syngeneic H-2b or H-2d viral lymphomas J. Exp. Med. 146:909–922.

    Article  PubMed  CAS  Google Scholar 

  36. Gomard, E., Henin, Y., Colombani, M. J., and Levy, J. P., 1980, Immune response genes control T-killer-cell response against Moloney tumor-antigen cytolysis regulating reactions against the best available H-2 + viral antigen association, J.. Exp. Med. 151:1468–1476.

    Article  PubMed  CAS  Google Scholar 

  37. Stukart, M. J., Vos, A., Boes, J., Melvold, R. W., Bailey, D. W., and Melief, C. J. M., 1982, A crucial role of the H-2D locus in the regulation of both the D-and K-associated cytotoxic T lymphocyte response against Moloney leukemia virus, demonstrated with two Db mutants, J. Immunol. 128:1360–1364.

    PubMed  CAS  Google Scholar 

  38. Schrier, P. I., Benards, R., Vaessen, R. T. M. J., Houweling, A., and van der Eb, A. J., 1983, Expression of class I major histocompatibility antigens switch off by highly oncogenic Adenovirus 12 in transformed rat cells, Nature 305:771–776.

    Article  PubMed  CAS  Google Scholar 

  39. Bernards, R., Schrier, P. I., Houweling, A., Bos, J. L., van der Eb, A. J., Zijlstra, M., and Melief, C. J. M., 1983, Tumorigenicity of cells transformed by Adenovirus type 12 by evasion of T-cell immunity, Nature 305:776–779.

    Article  PubMed  CAS  Google Scholar 

  40. Tanaka, K., Isselbacher, K.J., Khoury, G., and Jay, G., 1985, Reversal of oncogenesis by the expression of a major histocompatibility complex class I gene, Science 228:26–30.

    Article  PubMed  CAS  Google Scholar 

  41. Flyer, D. C., Burakoff, S. J., and Faller, D. V., 1985, Retrovirus-induced changes in major histocompatability complex antigen expression influence susceptibility to lysis by cytotoxic T lymphocytes, J. Immunol. 135:2287–2292.

    PubMed  CAS  Google Scholar 

  42. Meruelo, D., Nimelstein, S. H., Jones, P. P., Lieberman, M., and McDevitt, H., 1978, Increased synthesis and expression of H-2 antigens on the thymocytes as a result of radiation leukemia virus infection: A possible mechanism for H-2 linked control of virus-induced neoplasia, J. Exp. Med. 147:470–487.

    Article  PubMed  CAS  Google Scholar 

  43. Henley ,S. L., Weise, K. S., and Acton, R. T., 1984, Productive murine leukemia virus (MuLV) infection of EL-4 lymphoblastoid cells: Selective elevation of H-2 surface expression and possible association of Thy-1 antigen with viruses, Adv. Exp. Med. Biol. 172:365–377.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, 02115, USA

    David C. Flyer, Douglas V. Faller & Steven J. Burakoff

Authors
  1. David C. Flyer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Douglas V. Faller
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Steven J. Burakoff
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Immunology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104-6082, USA

    Mark I. Greene

  2. Department of Oncogenesis, Institute for Cancer Research, Osaka University Medical School, Osaka, 553, Japan

    Toshiyuki Hamaoka

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Plenum Press, New York

About this chapter

Cite this chapter

Flyer, D.C., Faller, D.V., Burakoff, S.J. (1987). Antigenic Requirements for the Recognition of Moloney Murine Leukemia Virus-Induced Tumors by Cytotoxic T Lymphocytes. In: Greene, M.I., Hamaoka, T. (eds) Development and Recognition of the Transformed Cell. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1925-2_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1925-2_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9070-4

  • Online ISBN: 978-1-4613-1925-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation