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Adriamycin Cardiac Toxicity — An Assessment of Approaches to Cardiac Monitoring and Cardioprotection

  • Chapter
Organ Directed Toxicities of Anticancer Drugs

Part of the book series: Developments in Oncology ((DION,volume 53))

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Abstract

Adriamycin is one of the most effective chemotherapeutic agents in the treatment of a broad spectrum of malignancies. The initial discovery that its prolonged use could lead to progressive, refractory, irreversible and almost uniformly fatal congestive heart failure has been a major impediment to its more widespread use in the curative treatment of early cancer and to prolonging its use in responding patients with advanced disease.

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References

  1. Lefrak, E.A., Pitha, J., Rosenheim, S., Gottlieb, J.A. (1973) Cancer 32: 302–314.

    Article  PubMed  CAS  Google Scholar 

  2. Minow, R.A., Benjamin, R.S., Lee, E.T., Gottlieb, J.A. (1977) Cancer 39: 1397–1402.

    Article  PubMed  CAS  Google Scholar 

  3. Von Hoff, D.D., Layard, M.W., Basas, P., et al. (1979) Ann Intern Med 91: 710–717.

    Google Scholar 

  4. Haq, M.M., Legha, S.S., Choksi, J., et al. (1985) Cancer 56: 1361–1365.

    Article  PubMed  CAS  Google Scholar 

  5. Billingham, M., Bristow, M.R., Glatstein, E., et al. (1977) Am J Surg Path 1: 17–23.

    Article  PubMed  CAS  Google Scholar 

  6. Bristow, M.R., Mason, J.W., Billingham, M.E., et al. (1978) Ann Intern Med 88: 169–175.

    Google Scholar 

  7. Mackay, B., Keyes, L.M., Benjamin, R.S., et al, (1981) TX Soc Electron Micro J 11: 7–15.

    Google Scholar 

  8. Legha, S.S., Benjamin, R.S., Mackay, B., et al. (1982) Ann Intern Med 96: 133–139.

    PubMed  CAS  Google Scholar 

  9. Chawla, S.P., Benjamin, R.S., Legha, S.S., et al. (1983)IN: Proceedings of the 13th International Congress of Chemotherapy eds. Spitzy, K.H., and Karrer, K. (Verlag H. Egermann, Vienna), pp. 490–492.

    Google Scholar 

  10. Benjamin, R.S., Chawla, S.P., Hortobagyi, G.N., et al. (1986) IN: Clinical Applications of Continuous Infusion Chemotherapy and Concomitant Radiation Therapy eds. Rosenthal, C.J. and Rotman, M. (Plenum Press, New York), pp. 19–25.

    Chapter  Google Scholar 

  11. Alexander, J., Dainiak, N., Berger, H.J., et al. (1979) NEJM 300: 278–283.

    Article  PubMed  CAS  Google Scholar 

  12. Ewer, M.S., Ali, M.K., Chawla, S.P., et al. (1985) Proc Am Soc Clin Oncol 4: 27.

    Google Scholar 

  13. Blum, R.H., Carter, S.K. (1974) Ann Intern Med 80: 249–259.

    PubMed  CAS  Google Scholar 

  14. Benjamin, R.S. (1975) Cancer Chemotherap Rep 6: 191–194.

    Google Scholar 

  15. Benjamin, R.S, Riggs C.E. Jr., and Bachur, N.R. (1973) Clinical Pharm and Therap 14: 592–600.

    CAS  Google Scholar 

  16. Benjamin, R.S., Wiernik, P.H., and Bachur, N.R. (1974) Cancer 33: 19–37.

    Article  PubMed  CAS  Google Scholar 

  17. Weiss, A.J., Metter, G.E., Fletcher, W.S., et al. (1976) Cancer Treat Rep 60: 813–822.

    PubMed  CAS  Google Scholar 

  18. Chlebowski, R.T., Paroly, W.S., Pugh, R.P., et al. (1980) Cancer Treat Rep 64: 47–51.

    PubMed  CAS  Google Scholar 

  19. Valdivieso, M., Burgess, M.A., Ewer, M.S., et al. (1984) J Clin Oncology 2: 207–214.

    CAS  Google Scholar 

  20. Torti, F.M., Bristow, M.R., Howes, A.E., et al. (1983) Ann Intern Med 99: 745–749.

    PubMed  CAS  Google Scholar 

  21. Legha, S.S., Benjamin, R.S., Mackay, B, et al. (1982) Cancer 49: 1763–1766.

    Article  Google Scholar 

  22. Jain, K.K., Casper, E. S. Geller, N.L., et al. (1985) J Clin Oncol 3: 818–826.

    PubMed  CAS  Google Scholar 

  23. Chawla, S.P., Benjamin, R.S., Hortobagyi, G.N. et al. (1986) Proc Am Soc Clin Oncol 5: 44.

    Google Scholar 

  24. Benjamin, R.S., Holmes, F, Chawla, S.P., et al. (1985) Current Status of Navatrone pp 69–73.

    Google Scholar 

  25. Dukart, G., Posner, L., Henry, D., et al. (1986) Proc Am Soc Clin Oncol 5: 48.

    Google Scholar 

  26. Myers, C.E, McGuire, W.P. Liss, R.H, et al. (1977) Science 197: 165–167.

    Article  PubMed  CAS  Google Scholar 

  27. Doroshow, J.H., Locker, G.Y, Ifrim, I., et al. (1981) J Clin Invest 64: 1053–1056.

    Article  Google Scholar 

  28. Legha, S.S, Wang, Y.M., Mackay, B, et al. (1982) Ann NY Acad Sci 393: 411–418.

    Article  PubMed  CAS  Google Scholar 

  29. Myers, C., Bonow, R., Palmeri, S., et al. (1983) Sem Oncol 10: 53–55.

    CAS  Google Scholar 

  30. Herman, E.H., Ferrans, V.J., Myers, C.E., and Van Vleet, J.F. (1985) Cancer Research 45: 276–381.

    PubMed  CAS  Google Scholar 

  31. Green, M.D., Speyer, J.L., Stecy, P., et al. (1987) Proc Am Soc Clin Oncol 6: 28.

    Google Scholar 

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Authors
  1. R. S. Benjamin
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  2. S. P. Chawla
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  3. M. S. Ewer
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  4. G. N. Hortobagyi
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  5. B. Mackay
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  6. S. S. Legha
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  7. C. H. Carrasco
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  8. S. Wallace
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Editor information

Editors and Affiliations

  1. Vermont Regional Cancer Center, Burlington, Vermont, USA

    Miles P. Hacker

  2. Yale University School of Medicine, New Haven, Connecticut, USA

    John S. Lazo

  3. Vermont Regional Cancer Center, Burlington, Vermont, USA

    Thomas R. Tritton

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© 1988 Martinus Nijhoff Publishing, Boston

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Benjamin, R.S. et al. (1988). Adriamycin Cardiac Toxicity — An Assessment of Approaches to Cardiac Monitoring and Cardioprotection. In: Hacker, M.P., Lazo, J.S., Tritton, T.R. (eds) Organ Directed Toxicities of Anticancer Drugs. Developments in Oncology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2023-4_5

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  • DOI: https://doi.org/10.1007/978-1-4613-2023-4_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9205-0

  • Online ISBN: 978-1-4613-2023-4

  • eBook Packages: Springer Book Archive

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