Skip to main content

Natural History and Prognosis

  • Chapter
IgA Nephropathy

Part of the book series: Topics in Renal Medicine ((TIRM,volume 2))

Abstract

Our knowledge of the natural history of idiopathic IgA mesangial nephropathy is still incomplete for two major reasons: (a) the disease has been characterized and recognized as a distinct clinical and pathologic entity only in these last 15 years, with the worldwide application of immunofluorescence microscopy to renal biopsies, and therefore clinical data from long-term observations of large series of patients are still scarce; and (b) for the subgroup of patients whose disease is discovered by chance because of asymptomatic urinary abnormalities, it is impossible to identify the time of onset.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Droz D: Natural history of primary glomerulonephritis with mesangial deposits of IgA. Contrib Nephrol 2:150–156, 1976.

    Google Scholar 

  2. Clarkson AR, Seymour AE, Thompson AJ, Haynes WDG, Chan YL, Jackson B: IgA nephropathy: a syndrome of uniform morphology, diverse clinical features and uncertain prognosis. Clin Nephrol 8:459–471, 1977.

    PubMed  CAS  Google Scholar 

  3. Imbasciati E, Colasanti G, Barbiano di Belgioioso, Banfi G, Durante A, Ragni A, Ponticelli C, Minetti L, D’Amico G: Long-term follow-up of IgA mesangial deposits glomerulonephritis. Proc Eur Dial Transplant Assoc 14:472–475, 1977.

    PubMed  CAS  Google Scholar 

  4. Van der Peet J, Arisz L, Brentjens JRH, Marrink J, Hoedemaeker PJ: The clinical course of IgA nephropathy in adults. Clin Nephrol 8:335–340, 1977.

    PubMed  Google Scholar 

  5. Ueda Y, Sakai O, Yamagata M, Kitajima T, Kawamura K: IgA glomerulonephritis in Japan. Contrib Nephrol 4:36–47, 1977.

    Google Scholar 

  6. Yokoska H, Nagase M, Maeda K: Mesangial IgA glomerulonephritis: clinicopathological study of 85 cases. Contrib Nephrol 9:101–110, 1978.

    PubMed  CAS  Google Scholar 

  7. Shirai T, Tomino Y, Yoshiki T, Itoh T: IgA nephropathy: clinicopathology and immunepathology. Contrib Nephrol 9:88–100, 1978.

    PubMed  CAS  Google Scholar 

  8. Nakamoto Y, Asano Y, Dohi K, Fujioka M, Iida H, Kibe Y, Hattori N, Takeuchi J: Primary IgA glomerulonephritis and Schönlein-Henoch purpura nephritis: clinicopathological and immunohistological characteristics. Q J Med 47:495–516, 1978.

    PubMed  CAS  Google Scholar 

  9. Sakai O, Kitajima T, Kawamura K, Ueda Y: Clinicopathological studies on IgA glomerulonephritis. In: Yoshitoshi Y, Ueda Y (eds) Glomerulonephritis. Baltimore: University Park Press 1979, p 167.

    Google Scholar 

  10. Gärtner HV, Honlein F, Traub U, Bohle A: IgA-nephropathy (IgA-IgG nephropathy, IgA-nephritis): a disease entity? Virchows Arch [Pathol Anat] 385:1–27, 1979.

    Article  Google Scholar 

  11. Burkholder PM, Zimmerman SW, Moorthy AV: A clinicopathological study of the natural history of mesangial IgA nephropathy. In: Yoshitoshi Y, Ueda Y (eds) Glomerulonephritis. Baltimore: University Park Press, 1979, p 143.

    Google Scholar 

  12. Egido J, Riviera Hernandez F, Sancho J, Moreno M, Kreisler M, Hernando L: Estudio del sistema HLA yy factores de riesgo para la insuficiencia renal en la glomerulonephritis mesangial IgA. Nefrologia 1:21–27, 1981.

    Google Scholar 

  13. Sinniah R, Javier AR, Ku G: The pathology of mesangial IgA nephritis with clinical correlation. Histopathology 5:469–490, 1981.

    Article  PubMed  CAS  Google Scholar 

  14. D’Amico G, Ferrario F, Colasanti G, Ragni A, Bestetti M: IgA mesangial nephropathy (Berger’S disease) with rapid decline in renal function. Clin Nephrol 16:251–257, 1981.

    PubMed  Google Scholar 

  15. Hood SA, Velosa JA, Holley KE, Donadio JV: IgA-IgG-nephropathy: predictive indices of progressive disease. Clin Nephrol 16:55–62, 1981.

    PubMed  CAS  Google Scholar 

  16. Berger J, Yaneva H, Crosnier J: La glomérulonephrite à dépôts mésangiaux d’IgA: une cause fréquente d’insuffisance rénale terminale. Nouv Presse Med 9:219–221, 1980.

    PubMed  CAS  Google Scholar 

  17. Lee SMK, Rao MV, Franklin WA, Schiffer MS, Aronson AJ, Spargo BK, Katz AI: IgA negphropathy: morphologic predictors of progressive renal disease. Hum Pathol 13:314–322, 1982.

    Article  PubMed  CAS  Google Scholar 

  18. Gutierrez-Millet V, Navas Palacios JJ, Prieto C, Ruilope LM, Usera G, Barrientos A, Alcazar JM, Perez AJ, Jarillo MD, Rodicio JL: Glomerulonephritis mesangial IgA idiopatica: estudio clinico e immunopathologico de 40 casos y revision de la literatura. Nefrologia 2:21–34, 1982.

    Google Scholar 

  19. Feiner HD, Cabili S, Baldwin DS, Schacht RG, Gallo GR: Intrarenal vascular sclerosis in IgA nephropathy. Clin Nephrol 18:183–192, 1982.

    PubMed  CAS  Google Scholar 

  20. Southwest Pediatric Nephrology Study Group: A multicentric study of IgA nephropathy in children. Kidney Int 22:643–652, 1982.

    Article  Google Scholar 

  21. Coppo R, Basolo B, Martina G, Rollino C, De Marchi M, Giacchino F, Mazzucco G, Messina M, Piccoli G: Circulating immune complexes containing IgA and IgM in patients with primary IgA nephropathy and with Henoch-Schönlein nephritis: correlation with clinical and histologic signs of activity. Clin Nephrol 18:230–239, 1982.

    PubMed  CAS  Google Scholar 

  22. Rambausek WL, Seeling HP, Andrassy K, Waldherr R, Kehry I, Lenhard V, Ritz E: Mesangial IgA-Glomerulonephritis: neue Aspekte zur Diagnose, Klinik und Prognose. Dtsch Med Wochenschr 108:125–130, 1983.

    Article  PubMed  CAS  Google Scholar 

  23. Kitajima T, Murakami M, Sakai O: Clinicopathological features in the Japanese patients with IgA nephropathy. Jpn J Med 22:219–222, 1983.

    Article  PubMed  CAS  Google Scholar 

  24. Croker BP, Dawson DV, Sanfilippo F: IgA nephropathy: correlation of clinical and histologic features. Lab Invest 48:19–24, 1983.

    PubMed  CAS  Google Scholar 

  25. Kobayashi Y, Tateno S, Hiki Y, Shigematsu H: IgA nephropathy: prognostic significance of proteinuria and histological alteration. Nephron 34:146–153, 1983.

    Article  PubMed  CAS  Google Scholar 

  26. Rambausek M, Seeling HP, Andrassy K, Waldherr R, Lenhard V, Ritz E: Clinical and serological features of mesangial IgA glomerulonephritis. Proc Eur Dial Transplant Assoc 19:663–668, 1983.

    PubMed  CAS  Google Scholar 

  27. Katz A, Walker JF, Landy PJ: IgA nephritis with nephrotic range proteinuria. Clin Nephrol 20:67–71, 1983.

    PubMed  CAS  Google Scholar 

  28. D’Amico G, Barbiano di Belgioioso G, Imbasciati E, Fogazzi G, Radaelli L, Ferrario F, Fellin G, Ponticelli C, Minetti L: Idiopathic IgA mesangial nephropathy: natural history. Contrib Nephrol 40:208–213, 1984.

    PubMed  Google Scholar 

  29. D’Amico G: Natural history and treatment of idiopathic IgA nephropathy. In: Robinson RR (ed) Nephrology. New York: Springer, 1984, p 686.

    Google Scholar 

  30. Clarkson AR, Woodroffe AJ, Bannister KM, Lomax-Smith JD, Aarons I: The syndrome of IgA nephropathy. Clin Nephrol 21:7–14, 1984.

    PubMed  CAS  Google Scholar 

  31. Rodicio JL: Idiopathic IgA nephropathy. Kidney Int 25:717–729, 1984.

    Article  PubMed  CAS  Google Scholar 

  32. Droz D, Kramar A, Nawar T, Noel LH: Primary IgA nephropathy: prognostic factors. Contrib Nephrol 40:202–207, 1984.

    PubMed  CAS  Google Scholar 

  33. Nicholls KM, Fairley KF, Dowling JP, Kincaid-Smith P: The clinical course of mesangial IgA-associated nephropathy in adults. Q J Med 210:227–250, 1984.

    Google Scholar 

  34. Beukhof JR, Ockhuizen Th, Halie LM, Westra J, Beelen JM, Donker AJ M, Hoedemaeker Ph J, Van der Hem GK: Subentities within adult primary IgA-nephropathy. Clin Nephrol 22:195–199, 1984.

    PubMed  CAS  Google Scholar 

  35. D’Amico G, Imbasciati E, Barbiano di Belgioioso G, Bertoli S, Fogazzi G, Ferrario F, Fellin G, Ragni A, Colasanti G, Minetti L, Ponticelli C: Idiopathic IgA mesangial nephropathy: clinical and histological study of 374 patients. Medicine 64:49–60, 1985.

    PubMed  Google Scholar 

  36. Kincaid-Smith PS: Mesangial IgA nephropathy. Br Med J: 96–97, 1985.

    Google Scholar 

  37. Sinniah R: IgA mesangial nephropathy: Berger’s disease. Am J Nephrol 5:73–83, 1985.

    Article  PubMed  CAS  Google Scholar 

  38. Glassock RJ, Kurotawa KV: IgA nephropathy in Japan. Am J Nephrol 5:127–137, 1985.

    Article  PubMed  CAS  Google Scholar 

  39. De Werra P, Morel-Maroger L, Leroux-Robert C, Richet G: Glomérulites à dépôts d’IgA diffus dans le mésangium: étude de 96 cas chez l’adulte. Schweiz Med Wochenschr 103:761–803, 1973.

    PubMed  Google Scholar 

  40. Abe T, Kida H, Yokoyama H, Hattori N: Significance of extracapillary lesions (ECL) for IgA nephropathy [abstr] In: Proceedings of the second Asian Pacific congress of nephrology, Melbourne, 1983, p 17.

    Google Scholar 

  41. Simon P, Ang KS, Bavay P, Cloup C, Miguard JP, Ramee MP: Glomérulonéprite à immunoglobulines A: epidémiologie dans une population de 250,000 habitants. Nouv Presse Med 13:257–260, 1984.

    CAS  Google Scholar 

  42. Legrain M, Salah H, Beaufils H, Flores Esteves L, Guedon J: Le prognostic de glomérulonéphrites chroniques primitives de l’adulte. Nouv Presse Med 7:533–538, 1978.

    PubMed  CAS  Google Scholar 

  43. Droz D, Noel LH: Ré-evaluation du prognostic des glomerulonéphrites à dépôts intracapillaires d’IgA. Semin Nephrol Pediatr 26–31, 1983.

    Google Scholar 

  44. Beukhof JR, Anema J, Halic LM, Fleuren GJ, Van der Hem GK: Prognosis of adult primary IgA nephropathy [abstr]. Kidney Int 24:408, 1983.

    Article  Google Scholar 

  45. Mustonen J, Pasternak A, Helin H, Rilva A, Penttinen K, Wager O, Harmoinen A: Circulating immune complexes, the concentration of serum IgA and the distribution of HLA antigens in IgA nephropathy. Nephron 29:170–175, 1981.

    Article  PubMed  CAS  Google Scholar 

  46. Vendemia F, Fornasieri A, Velis O, Baroni M, Scarduelli B, D’Amico G: Different prevalence rates of hypertension in various renoparenchimal diseases. In: Blaufox MD, Bianchi C (eds) Secondary forms of hypertension. New York: Grune and Stratton, 1980, p 89.

    Google Scholar 

  47. Martini A, Magrini U, Scelsi M, Capelli V, Barberis L: Chronic membranoproliferative IgA glomerulonephritis comlicated by a rapidly progressive course in a 14 years old boy. Nephron 29:164–166, 1981.

    Article  PubMed  CAS  Google Scholar 

  48. Abuelo JG, Esparza AR, Matarese RA, Endreny RG, Carvalho JS, Allegra SR: Crescentic IgA nephropathy. Medicine 63:396–406, 1984.

    Article  PubMed  CAS  Google Scholar 

  49. Surian M, Imbasciati E, Cosci P, Barbiano di Belgioioso G, Brancaccio D, Minetti L, Ponticelli C: Glomerular disease and pregnancy: a study of 123 pregnancies in patients with primary and secondary glomerular diseases. Nephron 36:101–105, 1984.

    Article  PubMed  CAS  Google Scholar 

  50. Berger J, Yaneva H, Nabarra B, Barbanel C: Recurrences of mesangial deposition of IgA after renal transplantation. Kidney Int 7:232–241, 1975.

    Article  PubMed  CAS  Google Scholar 

  51. Cameron JS, Turner DR: Recurrent glomerulonephritis in allografted kidneys. Clin Nephrol 7:47–54, 1977.

    PubMed  CAS  Google Scholar 

  52. Limas C, Spector D, Wright JR: Histologic changes in preserved cadaveric renal transplants. Am J Pathol 88:403–428 1977.

    PubMed  CAS  Google Scholar 

  53. Sanfilippo F, Croker BP, Bollinger RR: Fate of four cadaveric donor renal allografts with mesangial IgA deposits. Transplantation 33:370–376, 1982.

    Article  PubMed  CAS  Google Scholar 

  54. Silva FG, Chander P, Pirani CL: Disappearance of glomerular mesangial IgA deposits after renal allograft transplantation. Transplantation 33:214–216, 1982.

    Article  Google Scholar 

  55. Sissons JGP, Woodrow DF, Curtis JR, Evans DJ, Gover PE, Sloper JC, Peters DK: Isolated glomerulonephritis with mesangial IgA deposits. Br Med J 3:611–614, 1985.

    Article  Google Scholar 

  56. Beukhof JR, Kardaun O, Schaafsma W: Individual prognosis of patients with IgA-nephropathy on basis of the proportional hazard model, (in press).

    Google Scholar 

  57. Schmeckel B, Svalander C, Bucht H, Westberg NG: Mesangial IgA glomerulonephritis in adults. Acta Med Scand 363–372, 1981.

    Google Scholar 

  58. Shigematsu H, Kobayashi Y, Tateno S, Hiki Y, Kuwao S: Ultrastructural glomerular loop abnormalities in IgA nephritis. Nephron 30:1–7, 1982.

    Article  PubMed  CAS  Google Scholar 

  59. Ng WL, Chan CW, Yeung CK, Hua SP: The pathology of primary IgA glomerulonephritis: a renal biopsy study. Pathology 13:137–143, 1981.

    Article  PubMed  CAS  Google Scholar 

  60. McCoy RC, Abramowsky CR, Tisher CC: IgA nephropathy. Am J Pathol 76:123–144, 1974.

    PubMed  CAS  Google Scholar 

  61. Sinniah R, Pwee HS, Lim CH: Glomerular lesions in asymptomatic microscopic hematuria discovered on routine medical examination. Clin Nephrol 5:216–228, 1976.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Anthony R. Clarkson

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Martinus Nijihoff Publishing, Boston

About this chapter

Cite this chapter

D’amico, G. (1987). Natural History and Prognosis. In: Clarkson, A.R. (eds) IgA Nephropathy. Topics in Renal Medicine, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2039-5_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2039-5_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9213-5

  • Online ISBN: 978-1-4613-2039-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics