Abstract
Although neurologic manifestations of myeloma most commonly affect the spinal cord, peripheral neuromuscular symptoms are uncommon. The first report of peripheral nerve involvement in myeloma was probably that of Davison and Balser (1937) who reviewed the neurologic complications of multiple myeloma. Scheinker subsequently (1938) reported a pathological and clinical study of a case of polyneuropathy and a solitary sternal plasmacytoma, probably osteosclerotic. Additional reports followed by Crow (1956), Odelberg-Johnson (1959), Victor et al. (1958), Small et al. (1961), Rohmer et al. (1962), Aguayo (1964), Gupta and Prabhash (1965), and Rushton (1965) describing cases of myeloma and solitary myeloma (often with osteosclerotic features) with associated polyneuropathy. These patients presented with a variety of clinical syndromes ranging from a “Guillain-Barre-like” syndrome (Odelberg-Johnson, 1959) to a pure sensory neuropathy (Victor et al., 1958). Thus, early on it became apparent that the polyneuropathy associated with myeloma was complex and included patients with different types of myeloma (multiple myeloma-lytic type, solitary plasmacytoma, and osteosclerotic myeloma) and with different neurologic presentations within and between groups. In addition, although amyloidosis (AL) was known to occur in myeloma (Kyle and Bayrd, 1975), it was not recognized as a cause of polyneuropathy. In an influential paper, Victor et al. (1958) found mostly demyelination on histopathologic study of their five patients and no evidence of amyloid deposition, and they thus concluded that amyloid played no part in myeloma polyneuropathy.
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© 1987 Martinus Nijhoff Publishing, Boston
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Kelly, J.J. (1987). Multiple Myeloma. In: Polyneuropathies Associated with Plasma Cell Dyscrasias. Topics in the Neurosciences, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2065-4_6
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DOI: https://doi.org/10.1007/978-1-4613-2065-4_6
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