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Hepatic Artery Infusion (HAI) For Hepatic Metastases in Combination with Hepatic Resection or Hepatic Radiation

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Clinical Applications of Continuous Infusion Chemotherapy and Concomitant Radiation Therapy

Abstract

Hepatic metastasis is the major cause of death in advanced cancer of the colon and rectum. Survival after the diagnosis of liver metastases ranges from 3–12 months (4,6,7,14). Various modes of therapy have been attempted with only partial success. Resection of isolated hepatic metastases has yielded a 15–30% five year survival (1,3,12,13). Intraarterial infusion chemotherapy using an external catheter has been performed by several investigators with response rates of 50–60% (2,8,15,16). Survival, however, averages only 8 1/2 to 10 months, which is not significantly different from historical controls. The major problem with this therapy appears to be technical difficulties related to the external pump and catheter and the resultant necessity to terminate the intra-arterial chemotherapy (10). Radiation of the liver as an adjunct to hepatic infusion therapy has been utilized (5).

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Author information

Authors and Affiliations

  1. Department of Surgery, Medical College of Ohio at Toledo, USA

    H. W. Merrick

  2. Division of Radiation Therapy, Medical College of Ohio at Toledo, USA

    R. R. Dobelbower Jr

  3. Department of Medicine, Medical College of Ohio at Toledo, USA

    R. T. Skeel

Authors
  1. H. W. Merrick
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  2. R. R. Dobelbower Jr
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  3. J. F. Ringleint
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  4. R. T. Skeel
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Editor information

Editors and Affiliations

  1. Division of Medical Oncology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York, USA

    C. Julian Rosenthal M.D. (Associate Professor of Medicine, Director) (Associate Professor of Medicine, Director)

  2. Department of Radiation Oncology, State University of New York Health Science Center of Brooklyn, Brooklyn, New York, USA

    Marvin Rotman M.D. (Professor and Chairman) (Professor and Chairman)

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© 1986 Plenum Press, New York

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Merrick, H.W., Dobelbower, R.R., Ringleint, J.F., Skeel, R.T. (1986). Hepatic Artery Infusion (HAI) For Hepatic Metastases in Combination with Hepatic Resection or Hepatic Radiation. In: Rosenthal, C.J., Rotman, M. (eds) Clinical Applications of Continuous Infusion Chemotherapy and Concomitant Radiation Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2197-2_24

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  • DOI: https://doi.org/10.1007/978-1-4613-2197-2_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9291-3

  • Online ISBN: 978-1-4613-2197-2

  • eBook Packages: Springer Book Archive

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