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Beneficially Active Structural Entities in Endotoxin Preparations

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Immunobiology and Immunopharmacology of Bacterial Endotoxins

Part of the book series: University of South Florida International Biomedical Symposia Series ((EMISS,volume 18))

Abstract

The effects of endotoxin preparations can be divided into two large groups. One consists of reactions which are harmful and may lead to irreversible vascular collapse, shock and death. The other covers those which are beneficial, such as enhanced immune responsiveness, elevated non-specific resistance to microbial infections including fungi and viruses, increased leukopoiesis, activation of lymphocytes and of the functions of macrophages as well as of the entire reticuloendothelial system. Finally, one should mention the anti-tumor effects of endotoxins on some established animal malignancies and the resistance enhancement to transplantable experimental tumors induced by endotoxin. Table 1 shows some of those endotoxic effects which may be considered as beneficial.

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  1. Center for Oral Health Research, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

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  1. Alois Nowotny
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  1. University of South Florida College of Medicine, Tampa, Florida, USA

    Andor Szentivanyi (Dean of the College of Medicine Deputy Vice President for Medical Affairs Professor of Pharmacology and Internal Medicine Chairman of the Department of Pharmacology and Therapeutics) & Herman Friedman (Professor and Chairman) (Dean of the College of Medicine Deputy Vice President for Medical Affairs Professor of Pharmacology and Internal Medicine Chairman of the Department of Pharmacology and Therapeutics) &  (Professor and Chairman)

  2. University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

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© 1986 Plenum Press, New York

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Nowotny, A. (1986). Beneficially Active Structural Entities in Endotoxin Preparations. In: Szentivanyi, A., Friedman, H., Nowotny, A. (eds) Immunobiology and Immunopharmacology of Bacterial Endotoxins. University of South Florida International Biomedical Symposia Series, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2253-5_3

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  • DOI: https://doi.org/10.1007/978-1-4613-2253-5_3

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