Skip to main content
SpringerLink
Log in

Chemotherapeutic Management of Head and Neck Neoplasia

  • Chapter
Head and Neck Management of the Cancer Patient

Part of the book series: Developments in Oncology ((DION,volume 36))

  • 117 Accesses

Abstract

Head and neck cancer is a term that encompasses heterogeneous types of malignant tumors occurring in heterogeneous groups of patients. Histologically, squamous cell carcinoma is the most common type. Because of this heterogeneity, the natural history, disease-free survival, overall survival, and the local and regional failure may vary from one report to another.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Amer MH, Izbicki RM, Vaitkevicius VK, Al-Sarraf M: Combination chemotherapy with cis-diamminedichloroplatinum, Oncovin and bleomycin (COB) in advanced head and neck cancers: phase II. Cancer 45:217–233, 1980.

    PubMed  CAS  Google Scholar 

  2. Kish JA, Drelichman A, Weaver A, et al.: Cis-platinum and 5-fluorouracil infusion in patients with recurrent and disseminated epidermoid cancer of the head and neck. Proc ASCO 1:193, 1982.

    Google Scholar 

  3. Kish JA, Weaver A, Jacobs J, et al.: Cis-platinum and 5-fluorouracil infusion in patients with recurrent and disseminated epidermoid cancer of the head and neck. Cancer 53:1819–1824, 1984.

    PubMed  CAS  Google Scholar 

  4. Drelichman A, Cummings G, Al-Sarraf M: A randomized trial of the combination of cis-platinum, Oncovin and bleomycin (COB) vs. methotrexate in patients with advanced squamous cancer of the head and neck. Cancer 52:399–403, 1983.

    PubMed  CAS  Google Scholar 

  5. De Conti R.C, Schoenfeld D: A randomized prospective comparison of intermittent methotrexate, methotrexate with leucovorin and a methotrexate combination in head and neck cancer. Cancer 48:1061–1072, 1981.

    Google Scholar 

  6. Amer MH, Al-Sarraf M, Vaitkevicius VK: Factors that effect response to chemotherapy and survival of patients with advanced head and neck cancer. Cancer 43:2202–2206, 1979.

    PubMed  CAS  Google Scholar 

  7. Amrein PC, Fingert H, Weitzman SA: Cis-platin-vincristine-bleomycin therapy in squamous cell carcinoma of the head and neck. J Clin Oncol 1:421–427, 1983.

    PubMed  CAS  Google Scholar 

  8. Al-Sarraf M: The cost and clinical value of combination of cis-platinum, Oncovin and bleomycin (COB) vs. methotrexate in patients with advanced head and neck epidermoid cancer. Proc ASCO 21:354, 1980.

    Google Scholar 

  9. Bell R, Sullivan JR, Fleming WG, Grey PA, Miller HS: Results of treatment of head and neck carcinoma with high dose methotrexate. Clin Exp Pharmacol Physiol [Suppl] 5:22, 1979.

    Google Scholar 

  10. Capizzi RL, De Conti RC, Marsh JC, Bertino JR: Methotrexate therapy of head and neck cancer: improvement in therapeutic index by the use of the leucovorin rescue. Cancer Res 30:1782–1788, 1970.

    PubMed  CAS  Google Scholar 

  11. Frei E III, Blum RH, Pitman SW, et al.: High dose methotrexate with leucovorin rescue: rationale and spectrum of antitumor activity. Am J Med 68:370–376, 1973.

    Google Scholar 

  12. Hong WK, Schaefer S, Issell B, et al.: A prospective randomized trial of methotrexate versus cis-platinum in the treatment of recurrent squamous cell carcinoma of the head and neck. Cancer 52:206–210, 1983.

    PubMed  CAS  Google Scholar 

  13. Kaplan BH, Schoenfeld D, Vogl S: Treatment of recurrent or metastatic squamous cancer of the head and neck with methotrexate (M) plus Coryneb acterium parvum, or M plus bleomycin plus diamminedichloroplatinum: a prospective randomized trial of the Eastern Cooperative Oncology Group. Proc AACR 22:532, 1981.

    Google Scholar 

  14. Kirkwood JM, Canellos GP, Ervin TJ, et al.: Increased therapeutic index using moderate dose methotrexate-leucovorin in patients with advanced squamous carcinoma of the head and neck: a safe new effective regimen. Cancer 47: 2414–2421, 1981.

    PubMed  CAS  Google Scholar 

  15. Lehane DE, Lane M, Stucky WJ: A comparison of methotrexate (M) with methyl CCNU (MC) and bleomycin (B) in patients with advanced squamous cell carcinoma of the head and neck (H&N) region: a southwest Oncology Group Study. Proc ASCO 21:331, 1980.

    Google Scholar 

  16. Lane M, Moore JL III, Levin H, Smith FE: Methotrexate therapy for squamous cell carcinoma of the head and neck. JAMA 204:561–564, 1968.

    PubMed  CAS  Google Scholar 

  17. Leone LA, Albala MM, Rage VB: Treatment of carcinoma of the head and neck with intravenous methotrexate. Cancer 21:828–837, 1968.

    PubMed  CAS  Google Scholar 

  18. Mitchell MS, Wawro NW, De Conti RC, et al.: Effectiveness of high dose infusions of methotrexate followed by leucovorin in carcinoma of the head and neck. Cancer Res 28:1088–1094, 1968.

    PubMed  CAS  Google Scholar 

  19. Papac RJ, Lefkowitz E, Bertino JR: Methotrexate (NSC-740) in squamous cell carcinoma of the head and neck. II. Intermittent intravenous therapy. Cancer Chemother Rep 51:69–72, 1967.

    PubMed  CAS  Google Scholar 

  20. Priestman TJ: Results in fifty cases of advanced squamous cell carcinoma of the head and neck treated by intravenous chemotherapy. Br J Cancer 27:400–405, 1973.

    PubMed  CAS  Google Scholar 

  21. Vogler WR, Jacobs J, Moffitt S, et al.: Methotrexate therapy with or without citrovor-um factor in carcinoma of the head and neck, breast, and colon. Cancer Clin Trials 2:227–236, 1979.

    Google Scholar 

  22. Williams SD, Einhorn LH, Velez-Garcia E, et al.: Chemotherapy of head and neck cancer: comparison of cis-platinum + vinblastine + bleomycin (PVB) versus methotrexate. Proc ASCO 1:202, 1982.

    Google Scholar 

  23. Woods RL, Fox RM, Tattersall MHN: Methotrexate treatment of squamous cell head and neck cancers: dose response evaluations. Br Med J 282:600–602, 1981.

    CAS  Google Scholar 

  24. Bonadonna G, De Lana M, Monfardini S, et al.: Clinical trials with bleomycin in lymphomas and in solid tumors. Eur J Cancer 8:205–215, 1972.

    PubMed  CAS  Google Scholar 

  25. Durkin WJ, Pugh RP, Jacobs E, et al.: Bleomycin (NSC-125066) therapy of responsive solid tumors. Oncology 33:260–264, 1976.

    PubMed  CAS  Google Scholar 

  26. Clinical Screening Cooperative Group of the European Organization for Reserach on Treatment of Cancer: Study of the clinical efficiency of bleomycin in human cancer. Br Med J 2:643, 1970.

    Google Scholar 

  27. Haas CD, Coltman CA Jr, Gottlieb JA, et al.: Phase II evaluation of bleomycin: a Southwest Oncology Group Study. Cancer 38:8–12, 1976.

    PubMed  CAS  Google Scholar 

  28. Hainan KE, Bleehen NM, Brewin TB, et al.: Early clinical experience with bleomycin in the United Kingdom in a series of 105 patients. Br Med J 4:635–638, 1972.

    Google Scholar 

  29. Yagoda A, Mukherji B, Young C, et al.: Bleomycin: an antitumor antibiotic clinical experience in 274 patients. Ann Intern Med 77: 861–870, 1972.

    PubMed  CAS  Google Scholar 

  30. Hayat M, Bayssas M, Brule G, et al.: Cis-dichlorodiammineplatinum (CDDP) in chemotherapy of cancer. Biocheme 60:935–940, 1978.

    Google Scholar 

  31. Hill JM, Loeb E, Maclellan A, et al.: Clinical studies of platinum coordination compounds in the treatment of various malignant diseases. Cancer Chemother Rep 59:647–649, 1975.

    PubMed  CAS  Google Scholar 

  32. Jacobs C, Bertino JR, Goffinet DR, et al.: 24-hour infusion of cis-platinum in head and neck cancer. Cancer 42:2135–2140, 1978.

    PubMed  CAS  Google Scholar 

  33. Panettiere FJ, Lehane D, Fletcher WJ, et al.: Cis-platinum therapy of previously treated head and neck cancer: the Southwest Oncology Group two-dose-per-month outpatient regimen. Med Pediatr Oncol 8:221–225, 1980.

    PubMed  CAS  Google Scholar 

  34. Randolph VL, Wittes RE: Weekly administration of cisdiamminedichloroplatinum (II) without hydration or osmotic diuresis. Eur J Cancer 14:753–756, 1978.

    PubMed  CAS  Google Scholar 

  35. Sako, Razack MS, Kalnins I: Chemotherapy for advanced and recurrent squamous cell carcinoma of the head and neck with high and low dose cis-diamminedichloroplatinum. Am J Surg 136:529–533, 1978.

    PubMed  CAS  Google Scholar 

  36. Stephens R, Coltman C, Rossof A, et al.: Cis-dichlorodiammineplatinum (II) in adult patients: Southwest Oncology Group Studies. Cancer Treat Rep 63:1609–1610, 1979.

    PubMed  CAS  Google Scholar 

  37. Wittes RE, Cvitkovic E, Shah J, et al.: Cis-dichlorodiammineplatinum (II) in the treatment of epidermoid carcinoma of the head and neck. Cancer Treat Rep 61:359–366, 1977.

    PubMed  CAS  Google Scholar 

  38. Wittes R, Heller K, Randolph V, et al.: Cis-dichlorodiammineplatinum (II) based chemotherapy as initial treatment of advanced head and neck cancer. Cancer Treat Rep 63:1533–1538, 1970.

    Google Scholar 

  39. Wittes RE: Chemotherapy of head and neck cancer. Otolaryngol Clin North Am 13:515–520, 1980.

    PubMed  CAS  Google Scholar 

  40. Rozencweig M, Slavik M, Muggia FM, Carter SK: Overview of early and investigational che-motherapeutic agents in solid tumors. Med Pediatr Oncol 2:417–432, 1976.

    PubMed  CAS  Google Scholar 

  41. Rozencweig M, Von Hoff DD, Muggia FM: Investigational chemotherapeutic agents in head and neck cancer. Semin Oncol 4:425–429, 1977.

    PubMed  CAS  Google Scholar 

  42. Boccardo F, Barbieri A, Canobbio L, et al.: Phase II trial of thioproline in advanced epidermoid head and neck tumors. Cancer Treat Rep 66:585–586, 1982.

    PubMed  CAS  Google Scholar 

  43. Campbell M, Al-Sarraf M: Phase II Ftorafur therapy in previously treated squamous cell cancer of the head and neck. Cancer Treat Rep 64:713–715, 1981.

    Google Scholar 

  44. Chapman R, Kelson D, Gralla R: Phase II trials of methylglyoxal bis (guanylhydrazone) (MGBG) in three solid tumors. Proc ASCO 22: 526, 1981.

    Google Scholar 

  45. Creagan ET, Nichols WS, O’Fallen JR: Phase II evaluation of PALA in patients with advanced head and neck cancer. Cancer Treat Rep 65:827–829, 1981.

    PubMed  CAS  Google Scholar 

  46. Creagan ET, Fleming TR, Edmonson JH, Ingle JN: Phase II evaluation of maytansine in patients with advanced head and neck cancer. Cancer Treat Rep 63:2061–2062, 1979.

    PubMed  CAS  Google Scholar 

  47. Forastiere AA, Crain SM, Callahan K, Van Echo D, Mattox D, Thant M, Van Hoff DD, Wiernik PH: Phase II trial of aziridnylbenzo-quinone (AZQ) in head and neck cancer. Cancer Treat Rep 66:2097–2098, 1982.

    PubMed  CAS  Google Scholar 

  48. Kish JA, Al-Sarraf M: Unpublished data.

    Google Scholar 

  49. Kish J A, Al-Sarraf M: Aclacinomycin: phase II evaluation in advanced squamous carcinoma of the head and neck. Am J Clin Oncol (in press).

    Google Scholar 

  50. Papac RJ, Fischer JJ: Cytosine arabinoside (NSC 63878) in the treatment of epidermoid carcinomas of the head and neck. Cancer Chemother Rep 55:193–197, 1971.

    PubMed  CAS  Google Scholar 

  51. Perry DJ, Crain SM, Weltz MD, Wilson JP, Davis RK, Wooley PV, Forastiere AA, Taylor MG, Weiss RB: Phase II trial of mitoguanzone in patients with advanced squamous cell carcinoma of the head and neck. Cancer Treat Rep 67:91–92, 1983.

    PubMed  CAS  Google Scholar 

  52. Ratanatharathorn V, Drelichman A, Sexton-Porte M, Al-Sarraf M: Phase II evaluation of 4’-(9-acridinylamino)-methanesulfon-m-anisidine (AMSA) in patients with advanced head and neck cancers. Am J clin Oncol 5:29–32, 1982.

    PubMed  CAS  Google Scholar 

  53. Shah MK, Engstrom PE, Catalano RB, et al.: Phase II trial of Razoxan (ICRF-159) in patients with squamous cell carcinoma of the head and neck previously exposed to systemic chemotherapy. Cancer Treat Rep 66:557–558, 1982.

    PubMed  CAS  Google Scholar 

  54. Amer MH: Combination chemotherapy (COB) for advanced squamous cell carcinoma of the head and neck with Cytoxan (CTS), vincristine (VCR) and bleomycin (BLM). Proc ASCO 21:474, 1980.

    Google Scholar 

  55. Bianco AA, Taylor SG IV, Reich SD, et al.: Combination chemotherapy in head and neck squamous cancer. Proc ASCO 19:380, 1978.

    Google Scholar 

  56. Cortes EP, Kalra J, James R, et al.: Chemotherapy for head and neck cancer in relapse after prior radiotherapy and evaluation of method of bleomycin (Bleo) administration anti-tumor effect. Proc ASCO 21:364, 1980.

    Google Scholar 

  57. Didolkar MS, Coleman JJ, Elias EG, et al.: Chemotherapy for advanced carcinoma of head and neck: an effective out patient schedule of Cytoxan, Oncovin, methotrexate, and bleomycin. Head Neck Surg 4:92–97, 1981.

    PubMed  CAS  Google Scholar 

  58. Fazio M, Cavallero P, Minetto E, et al.: Polychemotherapy of advanced head and neck malignancies. Tumor 62:599–608, 1976.

    CAS  Google Scholar 

  59. Holoye PY, Byers RM, Gard DA, et al.: Combination chemotherapy of head and neck cancer. Cancer 42:1661–1669, 1978.

    PubMed  CAS  Google Scholar 

  60. Lester EP, Kinnealey A, Matz GJ: Sequential combination chemotherapy for advanced squamous cell carcinoma of the head and neck. Laryngoscope 89:1921–1929, 1979.

    PubMed  CAS  Google Scholar 

  61. Livingston RB, Einhorn LH, Burgess MA, Gottlieb JA: Sequential combination chemotherapy for advanced recurrent squamous carcinoma of the head and neck. Cancer Treat Rep 60:103–105, 1976.

    PubMed  CAS  Google Scholar 

  62. Perry MC, Davidson EM, Kardinal CG: Chemotherapy of recurrent squamous cell carcinoma of the head and neck. Proc ASCO 21:479, 1980.

    Google Scholar 

  63. Presant CA, Ratkin G, Klahr L, Brown C: Adriamycin, BCNU plus cyclophosphamide (ABC) in advanced carcinoma of the head and neck. Cancer 44:1571–1575, 1979.

    PubMed  CAS  Google Scholar 

  64. Stathopoulos G, Wiltsaw E, Price LA: Quadruple chemotherapy in advanced squamous cell carcinoma of the head and neck. Br J Clin Pract 30:188–189, 1976.

    PubMed  CAS  Google Scholar 

  65. Wittes RE, Spiro RH, Shah J, et al.: Chemotherapy of head and neck cancer: combination treatment with cyclophosphamide, adriamycin, methotrexate and bleomycin. Med Pediatr Oncol 3:301–309, 1977.

    PubMed  CAS  Google Scholar 

  66. Miyamoto T: A sequential combination of bleomycin and mitomycin-C in the treatment of advanced squamous cancers. Recent Results Cancer Res 63:179–190, 1978.

    PubMed  CAS  Google Scholar 

  67. Wheeler RH, Liepman MK, Baker SR, et al.: Bleomycin, vincristine, and mitomycin-C with or without methotrexate in the treatment of squamous cell carcinoma. Cancer Treat Rep 64:943–949, 1980.

    PubMed  CAS  Google Scholar 

  68. Huang AT, Lucas VS, Baughn SG, Cole TB: A trial of outpatient chemotherapy for recurrent head and neck tumors. Cancer 45:2038–2041, 1982.

    Google Scholar 

  69. Richman SP, Livingston RB, Gutterman JK, et al.: Chemotherapy versus chemoimmuno-therapy of head and neck cancer: report of a randomized study. Cancer Treat Rep 60:535–539, 1976.

    PubMed  CAS  Google Scholar 

  70. Brown AW Jr, Blom J, Butler WM, et al.: Combination chemotherapy with vinblastine, bleomycin and cis-diamminedichloroplatinum (II) in squamous cell carcinoma of the head and neck. Cancer 45:2830–2835, 1980.

    PubMed  Google Scholar 

  71. Caradonna R, Paladine W, Ruckdeschel JC, et al.: Methotrexate, bleomycin and high-dose cis-diamminedichloroplatinum (II) in the treatment of advanced epidermoid carcinoma of the head and neck. Cancer Treat Rep 63:489–491, 1979.

    PubMed  CAS  Google Scholar 

  72. Creagan ET, Fleming TR, Edmonson JH, et al.: Cyclophosphamide, adriamycin and cis-diamminedichloroplatinum (II) in the treatment of patients with advaned head and neck cancer. Cancer 47:240–244, 1981.

    PubMed  CAS  Google Scholar 

  73. Creagan ET, Fleming TR, Edmonson JH, et al.: Chemotherapy for advanced head and neck cancer with combination adriamycin, cyclophosphamide and cis-diamminedichloroplatinum (II): preliminary assessment of a one-day vs. three-day regimen. Cancer 47: 2549–2551, 1981.

    PubMed  CAS  Google Scholar 

  74. Elias EG, Chretien PB, Monnard E, et al.: Chemotherapy prior to local therapy in advanced squamous cell cancer of the head and neck: preliminary assessment of an intensive drug regimen. Cancer 43:1025–1031, 1979.

    PubMed  CAS  Google Scholar 

  75. Ervin TJ, Weichselbaum R, Miller D, et al.: Treatment of advanced squamous cell carcinoma of the head and neck with cis-platinum, bleomycin and methotrexate (PBM). Cancer Treat Rep 65:787–791, 1981.

    PubMed  CAS  Google Scholar 

  76. Jacobs C: High dose methotrexate and cis-platinum in the treatment of recurrent head and neck cancer. Recent Results Cancer Res 76: 290, 1979.

    Google Scholar 

  77. Jakse R, Lehnert M, Scherlacher A: Palliative chemotherapy of recurring squamous cell carcinomas of head and neck with the combination of cis-diamminedichloroplatinum (II) (DDP)/ adriamycin (ADM). Laryngol Rhinol Otol 61:524–528, 1981.

    Google Scholar 

  78. King GW, Halpin JJ, Smith RE, et al.: Cis-dichlorodiammineplatinum (II), methotrexate, bleomycin and vincristine in head and neck cancer: a pilot study. Cancer Treat Rep 63: 1735–1738, 1979.

    PubMed  CAS  Google Scholar 

  79. Kaplan BH, Vogl SE, Chiuten D, et al.: Chemotherapy of advanced cancer of the head and neck (HNCa) with methotrexate (M), bleomycin (B) and cis-diamminedichloroplatinum (D) in combination “MBD.” Proc ASCO 20:384.

    Google Scholar 

  80. Kuten A, Zidan J, Cohen Y, Robinson E: Multi-drug chemotherapy using bleomycin, methotrexate and cis-platinum alone or combined with radiotherapy in advanced head and neck cancer. Cancer Treat Rep 67:573–574, 1983.

    PubMed  CAS  Google Scholar 

  81. Murphy WK, Valdivieso M, Bodey GP, Freireich EG: Cis-dichlorodiammineplatinum (DDP), methotrexate (MTX) and bleomycin (BLM) chemotherapy for patients with advanced squamous cell carcinoma (SCC) of the head and neck (H&N). Proc AACR 21:166.

    Google Scholar 

  82. Perry DJ, Weltz MD, Brown AWJ, Henderson RL, Neglia WJ, Berenbert JL: Vinblastine, bleomycin and cis-platinum for recurrent or metastatic squamous cell carcinoma of the head and neck. Cancer 50:2257–2260, 1982.

    PubMed  CAS  Google Scholar 

  83. Vogl SE, Kaplan BH: Chemotherapy of advanced head and neck cancer with methotrexate, bleomycin and cis-diamminedichloroplatinum II in an effective outpatient schedule. Cancer 44:26–31, 1979.

    PubMed  CAS  Google Scholar 

  84. Vogl SE, Lerner H, Kaplan BM, et al.: Mitomycin-C, methotrexate, bleomycin and cis-diamminedichloroplatinum II in the chemotherapy of advanced squamous cell cancer of the head and neck. Cancer 50:6–9, 1982.

    PubMed  CAS  Google Scholar 

  85. Von Hoff D, Alberts D, Mattox D, et al.: Combination chemotherapy with cis-platinum, bleomycin and methotrexate in patients with advanced head and neck cancer. Cancer Clin Trials 4:215–218, 1981.

    Google Scholar 

  86. Wittes RE, Brescia F, Young EW, et al.: Combination chemotherapy with cis-diamminedichloroplatinum (II) and bleomycin in tumors of the head and neck. Oncology 32: 202–207, 1975.

    PubMed  CAS  Google Scholar 

  87. Costanzi JJ, Loukas D, Gagliano RG, et al.: Intravenous bleomycin infusion as a potential synchronizing agent in human disseminated malignancies: a preliminary report. Cancer 38:1503–1506, 1976.

    PubMed  CAS  Google Scholar 

  88. Eisenberger M, Denefrio JM, Kaplan DL, et al.: Combination chemotherapy with bleomycin (Bleo) and hydroxyurea (HU) in the treatment of advanced head and neck cancer. Proc ASCO 21:343, 1980.

    Google Scholar 

  89. Jacobs C: Use of methotrexate and 5-FU for recurrent head and neck cancer. Cancer Treat Rep 66:1925–1928, 1982.

    PubMed  CAS  Google Scholar 

  90. Pitman SW, Kowal CD, Papac RJ, Bertino JR: Sequential methotrexate-5-fluorouracil: a high active drug combination in advance squamous cell carcinoma of the head and neck. Presented at the international head and neck oncology ressearch conference, September 1980. Proc AACR-ASCO 21:473, 1980.

    Google Scholar 

  91. Raafat J, Oster MW: Combination chemotherapy for advanced squamous cell carcinoma of the head and neck. Cancer Treat Rep 64:187–189, 1980.

    PubMed  CAS  Google Scholar 

  92. Price LA, Hill BT, Calvert AH, et al.: Improved results in combination chemotherapy of head and neck cancer using a kinetically based approach: a randomized study with and without adriamycin. Oncology 35:26–28, 1978.

    PubMed  CAS  Google Scholar 

  93. Ringborg U, Ewert G, Kinnman J, et al.: Sequential methotrexate-5-flurorouracil treatment of squamous cell carcinoma of the head and neck. Cancer 52:971–973, 1983.

    PubMed  CAS  Google Scholar 

  94. Thatcher N, Blackledge G, Crowther D: Advanced recurrent squamous cell carcinoma of the head and neck: results of a chemotherapeutic regimen with adriamycin, bleomycin, 5-fluorouracil, methotrexate and vitamin A. Cancer 46:1324–1328, 1980.

    PubMed  CAS  Google Scholar 

  95. Woods RL, Stewart J, Fox RM, Tattersol MNH: Combination chemotherapy with vincristine, bleomycin and methotrexate for advanced head and neck cancer. Cancer Treat Rep 63:1997–1999, 1979.

    PubMed  CAS  Google Scholar 

  96. Yagoda A, Lippman AJ, Winn RJ, et al.: Combination chemotherapy with bleomycin and methotrexate in patients with advanced epidermoid cancer. Proc ASCO 16:247, 1975.

    Google Scholar 

  97. Kish J, Decker D, Bergsman K, Al-Sarraf M: Preliminary reports of treatment of recurrent squamous carcinoma of the head and neck with cis-platinum (CACP) 4–5FU infusion vs. CACP + 5FU bolus. Proc ASCO 2:163, 1983.

    Google Scholar 

  98. Donaldson RC: Chemoimmunotherapy for cancer of the head and neck. Am J Surg 126:507–512, 1973.

    PubMed  CAS  Google Scholar 

  99. Suen JY, Richman SP, Livingston RB, et al.: Results of BCG adjuvant immunotherapy in 100 patients with epidermoid carcinoma of the head and neck. Am J Surg 134:474–478, 1979.

    Google Scholar 

  100. Woods JE, De Santo LW, Ritts RE: A controlled study of combined methotrexate, BCG and INH therapy for squamous cell carcinoma of the head and neck. Surg Clin North Am 57:769–778, 1977.

    PubMed  CAS  Google Scholar 

  101. Donaldson RC, Banda F, Kuhn R: Methotrexate plus MER for head and neck cancer. In: Crispen RG (ed) Neoplasm immunity solid tumor therapy. Philadelphia, Franklin Institute, 1977, pp 243–248.

    Google Scholar 

  102. Khandikar JD, De Wys WD: Chemoimmu-notherapy of head and neck cancer. Am J Surg 135:688–695, 1978.

    Google Scholar 

  103. Papac R, Minor DR, Rudnick S, et al.: Controlled trial of methotrexate and bacillus Cal-mette-Guerin therapy for advanced head and neck cancer. Cancer Res 38:3150–3153, 1978.

    PubMed  CAS  Google Scholar 

  104. Olkowski ZL, Maren JR, Skeen MJ: Effects of combined immunotherapy with levamisole and bacillus Calmette-Guerin on immuno-competence of patients with squamous cell carcinoma of the cervix, head and neck, and lung undergoing radiation therapy. Cancer Treat Rep 62:1651–1661, 1978.

    PubMed  CAS  Google Scholar 

  105. Buechler M, Mukherji B, Chasin W, Nathanson L: High dose methotrexate with and without BCG therapy in advanced head and neck malignancy. Cancer 43:1095–1100, 1979.

    PubMed  CAS  Google Scholar 

  106. Perlin E: Immunotherapy in patients with oral and malignant disease. Otolaryngol Clin North Am 12:195–199, 1979.

    PubMed  CAS  Google Scholar 

  107. Amiel JL, Sancho-Garnier H, Vandenbrouk C, et al.: First results of a randomized trial on immunotherapy of head and neck tumors. Recent Results Cancer Res 68:318–323, 1979.

    Google Scholar 

  108. Zbar B, Conti G, Rapp HJ, et al.: Regression of established oral tumors after intralesional injection of living BCG cell walls. Cancer 43:1304–1307, 1979.

    PubMed  CAS  Google Scholar 

  109. Cheng VST, Suit HD, Wang CC, et al.: Clinical trial of Cory neb acterium pavrum (intra-lymph node and intravenous) and radiation therapy in the treatment of head and neck carcinoma. Cancer 49:235–244, 1982.

    Google Scholar 

  110. Vogl SE, Schoenfeld DA, Kaplan BH, et al.: Methotrexate alone or with regional subcutaneous Cory neb acterium pavrum in the treatment of recurrent and metastatic squamous cancer of the head and neck. Cancer 260:2295–2300, 1982.

    Google Scholar 

  111. Lundy J, Wanebo H, Pinsky C, et al.: Delayed hypersensitivity reactions in patients with squamous cell cancer of the head and neck. Am J Surg 128:530–533, 1974.

    PubMed  CAS  Google Scholar 

  112. Eilber FR, Morton DL, Ketcham AS: Immunologic abnormalities in head and neck cancer. Am J Cancer 128:534–538, 1974.

    CAS  Google Scholar 

  113. Jenkins VK, Roy P, Ellis HN, et al.: Lymphocyte response in patients with head and neck cancer. Arch Otolaryngol 102:596–600, 1976.

    PubMed  CAS  Google Scholar 

  114. Berenyi MR, Straus B, Avila R: T-rosettes in alcoholic cirrhosis of the liver. JAMA 232:44–46, 1975.

    PubMed  CAS  Google Scholar 

  115. Law DK, Dudrick SJ, Afdon NI: Immuno-competence of patients with protein-calorie malnutrition. Ann Intern Med 79:545–550, 1973.

    PubMed  CAS  Google Scholar 

  116. Silverman NA, Potvin C, Alexander JC, Chretien PB: In vitro lymphocyte reactivity and T-cell levels in chronic cigarette smokers. Clin Exp Immunol 22:285–292, 1975.

    PubMed  CAS  Google Scholar 

  117. Humphrey LJ, Rush BF: Chemotherapy for tumors of the chest wall and base of neck by arterial infusion. Arch Surg 96:810–813, 1968.

    PubMed  CAS  Google Scholar 

  118. Couture J: Intra-arterial infusion therapy for oral cancer. Can J Surg 11:420–423, 1968.

    PubMed  CAS  Google Scholar 

  119. Dhawan IK, Rao BNB, Kapur BML, Iyer N, Chari PS: A clinical, histological and histochem-ical study of intraarterial infusion chemotherapy in oral cancer. Indian J Med Res 59:1835–1840, 1971.

    PubMed  CAS  Google Scholar 

  120. Donegan WL, Harris HS: Factors influencing the success of arterial infusion chemotherapy for cancer of the head and neck. Am J Surg 123:549–559, 1972.

    PubMed  CAS  Google Scholar 

  121. Freckman HA: Results in 169 patients with cancer of the head and neck treated by intraarterial infusion therapy. Am J Surg 124:501–509, 1972.

    PubMed  CAS  Google Scholar 

  122. Sealy R, Helman P: Treatment of head and neck cancer with intra-arterial cytotoxic drugs and radiotherapy. Cancer 30:187–189, 1972.

    PubMed  CAS  Google Scholar 

  123. Huntington MC, Du Priest RW, Fletcher WS: Intra-arterial bleomycin therapy in inoperable squamous cell carcinomas. Cancer 31:153–158, 1973.

    PubMed  CAS  Google Scholar 

  124. Sealy R, Helman P, Greenstein A, Shipstone B: The treatment of locally advanced cancer of the head and neck with intra-arterial cytotoxicities, cobalt, and hyperbaric oxygen therapy. Cancer 34:497–500, 1974.

    PubMed  CAS  Google Scholar 

  125. Richard JM, Sancho H, Lepintre Y, Rodary J, Pierquin B: Intra-arterial methotrexate chemotherapy and telecobalt therapy in cancer of the oral cavity and oropharynx. Cancer 34:491–496, 1974.

    PubMed  CAS  Google Scholar 

  126. Donegan WC, Harris P: Regional chemotherapy with combined drugs in cancer of the head and neck. Cancer 38:1479–1483, 1976.

    PubMed  CAS  Google Scholar 

  127. Busse JM, Goffinet DR, Bagshaw MA: Late local recurrences in patients with head and neck cancer treated by irradiation and intra-arterial infusion. Int J Radiat Oncol Biol Phys 1:839–848, 1976.

    PubMed  CAS  Google Scholar 

  128. Auersperg M, Furlan L, Marolt F, Jarels B: Intra-arterial chemotherapy and radiotherapy in locally advanced cancer of the oral cavity and oropharynx. Int J Radiat Oncol Biol Phys 4:273–277, 1978.

    PubMed  CAS  Google Scholar 

  129. Andersson T, Andreasson L, Biorklund A, Brismar J, Einer A, Eneroth CM, Hellekaut C, Landberg T, Mattison W: Intra-arterial chemotherapy of malignant head and neck tumors with superselective angiographic technique. Acta Otolaryngol [Suppl] 360:167–170, 1979.

    CAS  Google Scholar 

  130. Hollman K, Jesch W, Kuehboack J, Dimo-poulos J: Combined intra-arterial chemotherapy and radiation therapy of tumors in the maxillofacial region. J Maxillofac Surg 7:191–197, 1979.

    Google Scholar 

  131. Baker SR, Ensminger WD, Niederhuber JE: Intra-arterial infusion chemotherapy for head and neck cancer using a totally implantable infusion pump. Head Neck Surg 4:118–124, 1981.

    PubMed  CAS  Google Scholar 

  132. Stephens FO, Harker GJS, Hambly CK: Treatment of advanced cancer of the lower lip in the use of intra-arterial or intravenous chemotherapy as basal treatment. Cancer 48:1309–1314, 1981.

    PubMed  CAS  Google Scholar 

  133. Mika H: Remission rates of advanced squamous cell carcinoma of the oral cavity and oropharynx after intra-arterial poly-chemotherapy with vincristine, methotrexate, bleomycin and cisplatin (VMBP). Laryngol Rhinol Otol 61:520–523, 1982.

    CAS  Google Scholar 

  134. Matras H, Burkle K, Watzek G, Kuhbock J, Potzi P, Dimopoulos J: Concept of cytostatic theapy in advanced tumors of the head and neck. J Maxillofac Surg 7:150–154, 1979.

    PubMed  CAS  Google Scholar 

  135. Clifford P, O’Connor AD, Durden-Smith J, et al.: Synchronous multiple drug chemotherapy and radiotherapy for advanced (stage III and IV) squamous carcinoma of the head and neck. Antibiot Chemother 24:60–72, 1978.

    PubMed  CAS  Google Scholar 

  136. O’Connor D, Clifford P, Edwards WG, Dalley VM, Durden-Smith J, Hollis BA, Caiman FM: Long-term results of VBM and radiotherapy in advanced head and neck cancer. Int J Radiat Oncol Biol Phys 8:1525–1531, 1982.

    PubMed  Google Scholar 

  137. Bezwoda WR, De Moor NG, Derman DP: Treatment of advanced head and neck cancer by means of radiation therapy plus chemotherapy: a randomized trial. Med Pediatr Oncol 6:353–350, 1979.

    PubMed  CAS  Google Scholar 

  138. Malaker K, Robson F, Schipper H: Combined modalities in the management of advanced head and neck cancers. J Otolaryngol 9:24–30, 1980.

    PubMed  CAS  Google Scholar 

  139. Marcial VA, Velez-Garcia E, Figueroa-Vallis NR, et al.: Multi-drug chemotherapy (vincristine-bleomycin-methotrexate) followed by radiotherapy in inoperable carcinomas of the head and neck. Int J Radiat Oncol Biol Phys 6:717–721, 1980.

    CAS  Google Scholar 

  140. Smith BL, Franz JL, Mira JG, Gates GA, Sarp J, Cruz AB Jr: Simultaneous combination radiotherapy and multi-drug chemotherapy for stage III and stage IV squamous cell carcinoma of the head and neck. J Surg Oncol 15:91–98, 1980.

    PubMed  CAS  Google Scholar 

  141. Sinclair WK: Hydroxyurea: differential lethal effects on cultured mammalian cells during the cell cycle. Science 150:1729–1731, 1965.

    PubMed  CAS  Google Scholar 

  142. Young CW, Hodas S: Hydroxyurea: inhibitory effect of DNA metabolism. Science 146:1172–1174, 1964.

    PubMed  CAS  Google Scholar 

  143. Richards GJ, Chambers RG: Hydroxyurea: a radiosensitizer in the treatment of neoplasms of the head and neck. Am J Roentgenol Radium Ther Nucl Med 105:55–565, 1969.

    Google Scholar 

  144. Richards GJ, Chambers RG: Hydroxyurea in the treatment of neoplasms of the head and neck. Am J Surg 126:513–518, 1973.

    PubMed  Google Scholar 

  145. Stefani S, Sells RW, Abbate J: Hydroxyurea and radiotherapy in head and neck cancer. Radiology 101:391–396, 1971.

    PubMed  CAS  Google Scholar 

  146. Hussey DH, Samuels ML: Combined hydroxyurea and radiotherapy: a new dosage schedule. South Med J 65:137–141, 1972.

    PubMed  CAS  Google Scholar 

  147. Lerner HJ: Concomitant hydroxyurea and irradiation: clinical experience with 100 patients with advanced head and neck cancer at Pennsylvania Hospital. Am J Surg 134:505–509, 1977.

    PubMed  CAS  Google Scholar 

  148. Rominger CJ: Hydroxyurea and radiation therapy in advanced neoplasms of the head and neck. AJR 111:103–108 1971.

    CAS  Google Scholar 

  149. Phillips FS, Sternberg SS, Schwartz HS, et al.: Hydroxyurea. I. Acute cell death in proliferating tissues in rats. Cancer Res 27:61–74, 1967.

    Google Scholar 

  150. Sinclair WK: Hydroxyurea revisited: a decade of clinical studies. Int J Radiat Oncol Biol Phys 7:631–637, 1981.

    PubMed  CAS  Google Scholar 

  151. Fazekos JT, Sommer C, Kramer S: Adjuvant intravenous methotrexate or definitive radiotherapy alone for advanced squamous cancers of the oral cavity, oropharynx, supraglottic larynx or hypopharynx: concluding report of an RTOG randomized trail on 638 patients. Int J Radiat Oncol Biol Phys 6:533–541, 1980.

    Google Scholar 

  152. Fazekos JT, Sommer C, Kramer S: Tumor regression and other prognosticators in advanced head and neck cancers. Int J Radiat Oncol Biol Phys 9:957–964, 1983.

    Google Scholar 

  153. Friedman M, De Nervais FN, Daly JF: Treatment of squamous cell carcinoma of the head and neck with combined methotrexate and irradiation. Cancer 26:711–721, 1970.

    PubMed  CAS  Google Scholar 

  154. Lustig RA, De Mare PA, Kramer S: Adjuvant methotrexate in the radiotherapeutic management of advanced tumors of the head and neck. Cancer 37:2703–2708, 1976.

    PubMed  CAS  Google Scholar 

  155. Taylor SG IV, Bytell DE, De Wys WD, et al.: Adjuvant methotrexate and leucovorin in head and neck squamous cancer. Arch Otolaryngol 104:647–651, 1978.

    PubMed  Google Scholar 

  156. Kirkwood JM, Miller D, Pitman S, et al.: Initial high dose methotrexate-leucovorin (MTX-LV) in advanced squamous carcinoma of the head and neck. Proc ASCO 19:398, 1978.

    Google Scholar 

  157. Knowlton AH, Percarpio B, Bobrow S, et al.: Methotrexate and radiation therapy in the treatment of advanced head and neck tumors. Radiology 116:709–712, 1975.

    PubMed  CAS  Google Scholar 

  158. Kramer S: Methotrexate and radiation therapy in the treatment of advanced squamous cell carcinoma of the oral cavity, oropharynx, supraglottic larynx and hypopharynx. Can J Otolaryngol 4:213–218, 1975.

    PubMed  CAS  Google Scholar 

  159. Pointon RCS, Askill CS, Hunter RD, Wilkinson PM: Treatment of advanced head and neck carcinoma with synchronous irradiation and methotrexate. Cancer Treat Rep [Suppl 1.1] 65:145–148, 1981.

    Google Scholar 

  160. Johnson RO, Kisken WA, Curreri AR: The response of squamous cell carcinoma to intraarterial infusion with 5-fluorouracil. Cancer Chemother Rep 24:29–33, 1962.

    Google Scholar 

  161. Johnson RO, Kisken WA, Curreri AR: A report upon arterial infusion with 5-fluorouracil in 100 patients. Gynecol Obstet 120:530–536, 1965.

    CAS  Google Scholar 

  162. Bagshaw MA: Possible role of potentiators in radiation therapy. Am J Roentgenol Radium Ther Nucl Med 85:822–833, 1961.

    PubMed  CAS  Google Scholar 

  163. Heidelberger C, Griesbach L, Montag BJ, et al.: Studies on fluorinated pyrimidines. II. Effects on transplanted tumors. Cancer Chemother Rep 18:305–307, 1985.

    Google Scholar 

  164. Vermund H, Hodgett J, Ansfield FJ: Effects of combined roentgen irradiation and chemotherapy on transplanted tumors in mice. Am J Roentgenol Radium Ther Nucl Med 85:559–567, 1961.

    PubMed  CAS  Google Scholar 

  165. Lawton RL, Latouretter HB, Collier RG: Simultaneous high-energy irradiation and chemotherapy. Arch Surg 91:155–160, 1965.

    Google Scholar 

  166. Gollin FF, Johnson RO: Pre-irradiation 5-fluorouracil infusion in advanced head and neck carcinomas. Cancer 27:768–770, 1971.

    PubMed  CAS  Google Scholar 

  167. Lo TCM, Wiley AL Jr, Ansfield FJ, et al.: Combined radiation therapy and 5-fluorouracil for advanced squamous cell carcinoma of the oral cavity and oropharynx: a randomized study. Am J Surg 126:229–235, 1976.

    CAS  Google Scholar 

  168. Terasima T, Umezowa H: Lethal effect of bleomycin on cultured mammalian cells. J Anti-biot 23:300–304, 1970.

    CAS  Google Scholar 

  169. Terasima T, Yasukawa M, Umazawa H: Breaks and rejoining of DNA in cultured mammalian cells treated with bleomycin. Gann 61:513–516, 1970.

    PubMed  CAS  Google Scholar 

  170. Jorgensen SJ: Time-dose relationships in combined bleomycin treatment and radiotherapy. Eur J Cancer 8:531–534, 1972.

    PubMed  CAS  Google Scholar 

  171. Hansen HS, Rygard J, Engelholm SA: Clinical use of combined bleomycin and radiation therapy for head and neck tumors and testicular cancers. Bull Cancer 68:371–378, 1976.

    Google Scholar 

  172. Shanta V, Krishnamurthi S: Combined therapy of oral cancer, bleomycin and radiation: a clinical trial. Clin Radiol 28:427–429, 1977.

    PubMed  CAS  Google Scholar 

  173. Shah PM, Shukla SN, Patel KM, et al.: Effect of bleomycin radiotherapy combination in management of head and neck squamous cell carcinoma. Cancer 48:1106–1109, 1981.

    PubMed  CAS  Google Scholar 

  174. Kapstad B: Cobalt and bleomycin against carcinomas of head and neck: a controlled clinical study. Acta Otolaryngol [Suppl] 360:171–173, 1979.

    CAS  Google Scholar 

  175. Seagren SL, Byfield JE, Nahum AM, et al.: Treatment of locally advanced squamous cell carcinoma of the head and neck with concurrent bleomycin and external beam radiation therapy. Int J Radiat Oncol Biol Phys 5:1531–1535, 1979.

    PubMed  CAS  Google Scholar 

  176. Rygard J, Hansen HS: Bleomycin as adjuvant in radiation therapy of advanced squamous cell carcinoma in the head and neck. Acta Otolaryngol [Suppl] 360:161–166, 1979.

    CAS  Google Scholar 

  177. Laccoureye H, Haguet JF: Bleomycin as a complement in the treatment of pharynx and larynx carcinomas: a three-year assessment. Gann Monogr Cancer Res 19:171–175, 1976.

    Google Scholar 

  178. Berdal P: Head and neck carcinoma: treatment with bleomycin and radiation. Gann Monogr Cancer Res 19:133–3149, 1976.

    Google Scholar 

  179. Suzuki V, Miyaki H, Saka M: Bleomycin treatment of maxillary cancer and 5-year survival. Gann Monogr Cancer Res 19:151–158, 1976.

    Google Scholar 

  180. Matsumura V, Soda T, Motomura K: Combined treatment for carcinomas of the paranasal sinuses irradiation and bleomycin. Eye Ear Nose Throat Monogr 52:25–34, 1973.

    Google Scholar 

  181. Cachin Y, Jortay A, Sancho H, et al.: Preliminary results of randomized E.O.R.T.C. study comparing radiotherapy and concomitant bleomycin to radiotherapy alone in epidermoid carcinomas of the oropharynx. Eur J Cancer 13:1389–1395, 1977.

    PubMed  CAS  Google Scholar 

  182. Silverberg IJ, Phillips TL, Fu KK, Chan PYM: Combined radiotherapy and bleomycin for advanced head and neck cancers: results of a phase I pilot study. Cancer Treat Rep 65:697–698, 1981.

    PubMed  CAS  Google Scholar 

  183. Zak M, Drobnik J: Effect of cis-dichloro-diammineplatinum (II) on the post-irradiation lethality in mice after irradiation with x-rays. Strahlentherapie 142:112–115, 1971.

    PubMed  CAS  Google Scholar 

  184. Wodinsky I, Swincarski J, Kensler CJ, Venditti JM: Combination radiotherapy and chemotherapy for P388 lymphatic leukemia in vivo. Cancer Treat Rep 4:73–97, 1974.

    CAS  Google Scholar 

  185. Richmond RC, Zimbrick JD, Hykes DL: Radiation induced DNA damage and lethality in E. coli as modified by the anti-tumor agent cis-dichlorodiammineplatinum (II). Radiat Res 71:447–460, 1977.

    PubMed  CAS  Google Scholar 

  186. Douple EB, Richmond RC, Logan ME: Therapeutic potentiation in a mouse mammary tumor and an intracerebral rat brain tumor by combined treatment with cis-dichlorodiammineplatinum (II) and radiation. J Clin Hema-tol Oncol 7:585–603, 1977.

    CAS  Google Scholar 

  187. Soloway MS, Morris CR, Suderth B: Radiation therapy and cis-diamminedichloroplatinum (II) in transplantable and primary murine bladder cancer. Int J Radiat Oncol Biol Phys 5:1355–1360, 1979.

    PubMed  CAS  Google Scholar 

  188. Twentyman PR, Kallman RF, Brown JM: The effect of time between x-irradiation and chemotherapy on the growth of three solid mouse tumors. III. Cis-diamminedichloroplatinum. Int J Radiat Oncol Biol Phys 5:1365–1367, 1979.

    PubMed  CAS  Google Scholar 

  189. Carde P, Laval F: Effect of cis-dichlorodiammineplatinum II and x-rays on mammalian cell survival. Int J Radiat Oncol Biol Phys 7:929–933, 1981.

    PubMed  CAS  Google Scholar 

  190. Overgaard J, Khan AR: Selective enhancement of radiation response in a C3H mammary carcinoma by cis-platinum. Cancer Treat Rep 65:501–503, 1981.

    PubMed  CAS  Google Scholar 

  191. Szumiel I, Nias AHW: The effect of combined treatment with a platinum complex and ionizing radiation on Chinese hamster ovary cells in vitro. Br J Cancer 33:450–458, 1976.

    PubMed  CAS  Google Scholar 

  192. Al-Sarraf M, Jacobs J, Kinzie J, et al.: Combined modality therapy utilizing single high intermittent dose of cis-platinum and radiation in patients with advanced head and neck cancer. Proc ASCO 2:159, 1983.

    Google Scholar 

  193. Taylor SG, Sisson GA, Bytell DE: Adjuvant chemoimmunotherapy of head and neck cancer. Recent Results Cancer Res 68:297–308, 1979.

    Google Scholar 

  194. Szpirglas H, Chastang C, Bertrand JC: Adjuvant treatment of tongue and floor of the mouth cancers. Recent Results Cancer Res 68:309–317, 1978.

    PubMed  CAS  Google Scholar 

  195. Wanebo HJ, Hilal EY, Strong EW, et al: Adjuvant trial of levamisole in patients with squamous cancer of the head and neck: a preliminary report. Recent Results Cancer Res 68:324–333, 1978.

    PubMed  CAS  Google Scholar 

  196. Tarpley JL, Chretien PB, Alexander JC, et al.: High dose methotrexate as a pre-operative adjuvant in the treatment of epidermoid carcinoma of the head and neck: a feasibility study and clinical trial. Am J Surg 130:147–152, 1975.

    Google Scholar 

  197. Randolph VL, Vallajo A, Spiro RH, et al.: Combination therapy of advanced head and neck cancer: induction of remissions with di-amminedichloroplatinum (II), bleomycin, and radiation therapy. Cancer 41:460–467, 1978.

    PubMed  CAS  Google Scholar 

  198. Arlen M: Combined radiation methotrexate therapy in preoperative management of cancer of the head and neck. Am J Surg 132:536–540, 1976.

    PubMed  CAS  Google Scholar 

  199. Carter SK: The chemotherapy of head and neck cancer. Semin Oncol 4:413–424, 1977.

    PubMed  CAS  Google Scholar 

  200. Hande KR, Chretien PB, Elias EG, et al: Thirty-six hour preoperative high-dose methotrexate infusion in patients with squamous carcinoma of the head and neck. Med Pediatr Oncol 6:39–45, 1979.

    PubMed  CAS  Google Scholar 

  201. Hong WK, Shapshay SM, Bhutani R, et al.: Induction chemotherapy in advanced squamous head and neck carcinoma with high-dose cis-platinum and bleomycin infusion. Cancer 44:19–25, 1979.

    PubMed  CAS  Google Scholar 

  202. Kloss R, Oster M, Blitzer A, et al.: Cis-platinum (P) and bleomycin (B) for previously untreated locally advanced squamous cell carcinoma of the head and neck. Proc ASCO 22:535, 1981.

    Google Scholar 

  203. Glick JH, Marcial V, Richter M, et al.: The adjuvant treatment of inoperable stage III and IV epidermoid carcinoma of the head and neck with platinum and bleomycin infusions prior to definitive radiotherapy: an RTOG pilot study. Cancer 46:1919–1924, 1980.

    PubMed  CAS  Google Scholar 

  204. Al-Sarraf M, Amer MH, Vaishampayan G, et al.: A multi-disciplinary therapeutic approach for advanced previously untreated epidermoid cancer of the head and neck: preliminary report. Int J Radiat Oncol Biol Phys 5:1421–1423, 1979.

    PubMed  CAS  Google Scholar 

  205. Wittes R, Heller K, Randolph V, et al.: Cis-dichlorodiammineplatinum (Il)-based chemotherapy as initial treatment of advanced head and neck cancer. Cancer Treat Rep 63:1533–1538, 1979.

    PubMed  CAS  Google Scholar 

  206. Brown AW, Blom J, Butler WM, et al: Combination chemotherapy with vinblastine, bleomycin, and cis-diamminedichloroplatinum (II) in squamous cell carcinoma of the head and neck. Cancer 45:2830–2835, 1980.

    PubMed  Google Scholar 

  207. Schuller DE, King GW, Smithe RE, et al.: Combination therapy protocol for stage III or IV carcinoma of the oral cavity, oropharynx, and hypopharynx. Laryngoscope 90:1263–1272, 1980.

    PubMed  CAS  Google Scholar 

  208. Peppard SB, Al-Sarraf M, Powers WE, et al.: Combination of cis-platinum, Oncovin, and bleomycin (COB) prior to surgery and/or radiotherapy in advanced untreated epidermoid cancer of the head and neck. Laryngoscope 90:1273–1280, 1980.

    PubMed  CAS  Google Scholar 

  209. Spaulding MB, Klotch D, Grillo J, et al.: Adjuvant chemotherapy in the treatment of advanced tumors of the head and neck. Am J Surg 140:538–542, 1980.

    PubMed  CAS  Google Scholar 

  210. Weaver A, Loh JJ-K, Vandenberg H, et al.: Combined modality therapy of advanced head and neck cancer. Am J Surg 140:549–552, 1980.

    PubMed  CAS  Google Scholar 

  211. Al-Sarraf M, Drelichman A, Jacobs J, et al.: Adjuvant chemotherapy with cis-platinum, Oncovin, and bleomycin followed by surgery and/or radiotherapy in patients with advanced previously untreated head and neck cancer: final report. In: Jones SE, Salmon SE (eds) Adjuvant therapy of cancer III. New York, Grune and Stratton, 1981, pp 145–152.

    Google Scholar 

  212. Hong WK, Shapshay SM: Treatment of previously untreated stage III and IV squamous cell carcinoma of the head and neck. Otolaryngol Clin North Am 13:521–528, 1980.

    PubMed  CAS  Google Scholar 

  213. Pennacchio JL, Hong WK, Shapshay S, et al.: Combination of cis-platinum and bleomycin prior to surgery and/or radiotherapy compared with radiotherapy alone for the treatment of advanced squamous cell carcinoma of the head and neck. Cancer 50:2795–2801, 1982.

    PubMed  CAS  Google Scholar 

  214. Schuller DE, Wilson HE, Smith RE, Batley F, James AD: Pre-operative reductive chemotherapy for locally advanced carcinoma of the oral cavity, oropharynx, and hypopharynx. Cancer 51:15–19, 1983.

    PubMed  CAS  Google Scholar 

  215. Spaulding MB, Kahn A, De Los Santos R, Klotch D, Lore JH Jr: Adjuvant chemotherapy in advanced head and neck cancer: an update. Am J Surg 144:432–436, 1982.

    PubMed  CAS  Google Scholar 

  216. Tannock I: Cummings B, Sorrenti V, ENT Group: Combination chemotherapy prior to radiation therapy for locally advanced squamous cell carcinoma of the head and neck. Cancer Treat Rep 66:1421–1424, 1982.

    PubMed  CAS  Google Scholar 

  217. Vogl SE, Lerner H, Kaplan BH, Caughlin C, Mormick B, Camacho F, Cinberg J: Failure of effective initial chemotherapy to modify the course of stage IV (Mo) squamous cancer of the head and neck. Cancer 50:840–847, 1982.

    PubMed  CAS  Google Scholar 

  218. Seifert P, Baker L, Reed M, Vaitkevicius VK: Comparison of continuously infused 5-fluorouracil with bolus injection in the treatment of patients with colo-rectal adenocarcinoma. Cancer 36:123–128, 1975.

    PubMed  CAS  Google Scholar 

  219. Ervin TJ, Kirkwood J, Weichselbaum RP, et al.: Improved survival for patients with advanced carcinoma of the head and neck treated with methotrexate-leucovorin prior to definitive radiotherapy or surgery. Laryngoscope 91: 1181–1190, 1981.

    PubMed  CAS  Google Scholar 

  220. Al-Sarraf M, Drelichman A, Peppard S, et al.: Adjuvant cisplatinum and 5-fluorouracil 96-hour infusion in previously untreated epidermoid cancers of the head and neck. Proc ASCO 22:428, 1981.

    Google Scholar 

  221. Kish J, Drelichman A, Jacobs J, et al.: Clinical trial of cis-platinum and 5-fluorouracil as initial treatment for advanced squamous cell carcinoma of the head and neck. Cancer Treat Rep 66:471–474, 1982.

    PubMed  CAS  Google Scholar 

  222. Decker DA, Drelichman A, Jacobs J, et al.: Adjuvant chemotherapy with cis-diammine-dichloroplatinum II and 120 hour infusion 5-fluorouracil in stage III and IV squamous cell carcinoma of the head and neck. Cancer 51: 1353–1355, 1983.

    PubMed  CAS  Google Scholar 

  223. Weaver A, Fleming S, Vandenberg H, et al.: Cis-platinum and 5-fluorouracil as initial therapy in advanced epidermoid cancer of the head and neck. Head Neck Surg 4:370–373, 1982.

    PubMed  CAS  Google Scholar 

  224. Decker DA, Drelichman A, Jacobs J, et al.: Adjuvant chemotherapy with high dose bolus cis-diamminedichloroplatinum II (CCD) and 120-hour infusion of 5-fluorouracil (5FU) in stage III and IV squamous cell carcinoma of the head and neck. Proc ASCO 1:195, 1982.

    Google Scholar 

  225. Weaver A, Fleming S, Kish J, et al.: Cis-platinum and 5-fluorouracil as induction therapy for advanced head and neck cancer. Am J Surg 144:445–448, 1982.

    PubMed  CAS  Google Scholar 

  226. Gale GR, Atkins LM, Meischen SJ, et al.: Combination chemotherapy of LI210 leukemia with platinum compounds and cyclophosphamide plus other selected antineoplastic agents. JNCI 57:1363–1366, 1976.

    CAS  Google Scholar 

  227. Gale GR, Atkins LM, Meischen SJ, et al.: Chemotherapy of advanced LI210 leukemia with platinum compounds in combination with other anti-tumor agents. Cancer Treat Rep 61:445–450, 1977.

    PubMed  CAS  Google Scholar 

  228. Speer RJ, Lapis S, Ridgway H, et al.: Cis-platinum diamminodichloride (PDD) in combination therapy of leukemia LI210. Wesley Med Bull 1:103–109, 1971.

    Google Scholar 

  229. Woodman RJ, Sirica AE, Gang M, et al.: The enhanced therapeutic effects of cis-platinum (II) diamminedichloride against L1210 leukemia when combined with cyclophosphamide or 1, 2-bis (3, 5-dioxopiperazine-l-yl)-propane or several other anti-tumor agents. Chemotherapy 18:169–183, 1973.

    PubMed  CAS  Google Scholar 

  230. Kline I: Potentially useful combinations of chemotherapy detected in mouse tumor systems. Cancer Chemother Rep [Part 2] 41:3343, 1974.

    Google Scholar 

  231. Schabel FM Jr, Trader MW, Laster WR Jr, et al.: Cis-dichlorodiamminoplatinum (II): combination chemotherapy and cross-resistance studies with tumors of mice. Cancer Treat Rep 63:1459–1473, 1979.

    PubMed  CAS  Google Scholar 

  232. Baker SR, Makuch RW, Wolf GT: Preoperative cis-platinum (DDP) and bleomycin (BLM) in patients with head and neck squamous cell carcinoma (HNSCC): prognostic factors for tumor response. The head and neck contracts program. Arch Otolaryngol 101: 683–689, 1981.

    Google Scholar 

  233. Schuller DE, King GW, Smith RE, et al.: Cis-platinum, methotrexate, bleomycin, and vincristine pre-operative chemotherapy. Head Neck Surg 3:262, 1981.

    Google Scholar 

  234. Kish J, Drelichman A, Weaver A, et al.: Cis-platinum and 5-fluorouracil infusion in patients with recurrent and disseminated epidermoid cancer of the head and neck. Proc ASCO 1:193, 1982.

    Google Scholar 

  235. Al-Sarraf M, Kinzie J, Jacobs J, et al.: New way of giving chemotherapy as part of multi-disciplinary treatment for patients with head and neck cancer: preliminary report. Proc AACR 23:134, 1982.

    Google Scholar 

  236. Ensley J, Jacobs J, Weaver A, et al.: Initial cis-platinum combination predicting response to radiotherapy in patients with advanced epidermoid cancers of the head and neck. Proc ASCO 1:197, 1982.

    Google Scholar 

  237. Fu KK, Leibel SA, Levine ML, Freidlander LM, Boles R, Phillips TL: Cancer of the major and minor salivary glands: analysis of pretreat-ment results and sites and causes of failure. Cancer 40:2882–2890, 1977.

    PubMed  CAS  Google Scholar 

  238. Reutschler R, Burges M, Byers R: Chemotherapy of malignant major salivary gland neoplasms: a 25 year review of M.D. Anderson Hospital Experiences. Cancer 40:619–624, 1977.

    Google Scholar 

  239. Suen JY, Johns ME: Chemotherapy for salivary gland cancer. Larynogoscope 92:235–239, 1982.

    CAS  Google Scholar 

  240. Posner MR, Ervin TJ, Weichselbaum RR, Fabian RL, Miller D: Chemotherapy of advanced salivary gland neoplasms. Cancer 50: 2261–2264, 1982.

    PubMed  CAS  Google Scholar 

  241. Alberts DS, Manning MR, Coulthard SW, Koopmann CF, Herman TS: Adriamycin/ cisplatinum/cyclophosphamide combination chemotherapy for advanced carcinoma of the parotid gland. Cancer 47:645–648, 1981.

    PubMed  CAS  Google Scholar 

  242. Tannock IF, Southerland DJ: Chemotherapy for adenoid cystic carcinoma. Cancer 46:452–454, 1980.

    PubMed  CAS  Google Scholar 

  243. Schramm VL Jr, Srodes C, Myers EH: Cispla-tin therapy for adenoid cystic carcinoma. Arch Otolaryngol 107:739–741, 1981.

    PubMed  Google Scholar 

  244. Skibba JL, Hurley JD, Ravela HC: Complete response of a metastatic adenoid cystic carcinoma of the parotid gland to chemotherapy. Cancer 47:2543–2548, 1981.

    PubMed  CAS  Google Scholar 

  245. Vermeer RJ, Pinedo HM: Partial remission of advanced adenoid cystic carcinoma obtained with adriamycin. Cancer 43:1604–1606, 1979.

    PubMed  CAS  Google Scholar 

  246. Johnson RO, Lang RD, Kisken WA, Curreri AR: Infusion of 5-fluorouracil in cylindroma treatment. Arch Otolaryngol 79:625–627, 1964.

    PubMed  CAS  Google Scholar 

  247. Budd GT, Groppa CW: Adenoid cystic carcinoma of the salivary gland: sustained complete response to chemotherapy. Cancer 51:589–590, 1983.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Muhyi Al-Sarraf
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Oral Diagnosis Baltimore College of Dental Surgery Dental School, University of Maryland, 21201, Baltimore, Maryland, USA

    Douglas E. Peterson D.M.D., Ph.D. (Associate Professor) (Associate Professor)

  2. Program of Oncology, University of Maryland, School of Medicine, 21201, Baltimore, Maryland, USA

    Douglas E. Peterson D.M.D., Ph.D. (Associate Professor) (Associate Professor)

  3. University of Maryland School of Medicine, 21201, Baltimore, Maryland, USA

    E. George Elias M.D., Ph.D. (Professor of Surgery and Oncology, Director of Surgical Oncology) (Professor of Surgery and Oncology, Director of Surgical Oncology)

  4. Division of Dentistry, Brigham and Women’s Hospital, 75 Francis Street, 02115, Boston, Massachusetts, USA

    Stephen T. Sonis D.M.D., D.M.Sc. (Chief, Associate Professor) (Chief, Associate Professor)

  5. Department of Oral Medicine and Oral Pathology, Harvard School of Dental Medicine, 02115, Boston, Massachusetts, USA

    Stephen T. Sonis D.M.D., D.M.Sc. (Chief, Associate Professor) (Chief, Associate Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Martinus Nijhoff Publishing, Boston

About this chapter

Cite this chapter

Al-Sarraf, M. (1986). Chemotherapeutic Management of Head and Neck Neoplasia. In: Peterson, D.E., Elias, E.G., Sonis, S.T. (eds) Head and Neck Management of the Cancer Patient. Developments in Oncology, vol 36. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2289-4_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2289-4_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9411-5

  • Online ISBN: 978-1-4613-2289-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation