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Clinical Investigation of the Diabetic Microcirculation

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Clinical Investigation of the Microcirculation

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 59))

Abstract

The introduction of insulin therapy in 1922 represented survival for ketosis-prone diabetic patients, but survival at a cost. Over the ensuing years it became clear that with an increasing duration of insulin-dependent diabetes, vascular, and more specifically microvascular ‘complications’ occurred. Lundbaek (1) linked characteristic disease of the retina, kidney and distal peripheral vasculature, and the concept of microangiopathy emerged emphasising the microvascular nature of the complications. Despite unprecedented levels of care for the diabetic patient, diabetic retinopathy remains the major cause of blindness amongst the working population of the United Kingdom (2), and diabetic nephropathy a major cause of death in those patients who contract the disease in youth (3). These sobering statistics point to a lack of understanding of the pathogenesis of diabetic microangiopathy and a virtual absence of proven preventative therapy.

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Authors and Affiliations

  1. Department of Physiology, Charing Cross and Westminster Medical School, London, UK

    John E. Tooke

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Editors and Affiliations

  1. Charing Cross and Westminster Medical School, University of London, UK

    John E. Tooke  & L. H. Smaje  & 

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© 1987 Martinus Nijhoff Publishing, Boston

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Tooke, J.E. (1987). Clinical Investigation of the Diabetic Microcirculation. In: Tooke, J.E., Smaje, L.H. (eds) Clinical Investigation of the Microcirculation. Developments in Cardiovascular Medicine, vol 59. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2335-8_12

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  • DOI: https://doi.org/10.1007/978-1-4613-2335-8_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9434-4

  • Online ISBN: 978-1-4613-2335-8

  • eBook Packages: Springer Book Archive

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